Total Synthesis of (+)-Rubriflordilactone A.
Fiche publication
Date publication
octobre 2015
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHAUBET Guilhem
Tous les auteurs :
Goh SS, Chaubet G, Gockel B, Cordonnier MC, Baars H, Phillips AW, Anderson EA
Lien Pubmed
Résumé
Two enantioselective total syntheses of the nortriterpenoid natural product rubriflordilactone A are described, which use palladium- or cobalt-catalyzed cyclizations to form the CDE rings, and converge on a late-stage synthetic intermediate. These key processes are set up through the convergent coupling of a common diyne component with appropriate AB-ring aldehydes, a strategy that sets the stage for the synthetic exploration of other members of this family of natural products.
Mots clés
cyclotrimerization, domino reactions, natural products, total synthesis, transition metal catalysis
Référence
Angew Chem Int Ed Engl. 2015 10 19;54(43):12618-21