Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold.

Póti ÁL, Bálint D, Alexa A, Sok P, Ozsváth K, Albert K, Turczel G, Magyari S, Ember O, Papp K, Király SB, Imre T, Németh K, Kurtán T, Gógl G, Varga S, Soós T, Reményi A

Nat Commun. 2024 10 4;15(1):8607

Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy.

Zambo B, Edelweiss E, Morlet B, Negroni L, Pajkos M, Dosztanyi Z, Ostergaard S, Trave G, Laporte J, Gogl G

Elife. 2024 07 12;13:

The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome.

Jimenez-Armijo A, Morkmued S, Ahumada JT, Kharouf N, de Feraudy Y, Gogl G, Riet F, Niederreither K, Laporte J, Birling MC, Selloum M, Herault Y, Hernandez M, Bloch-Zupan A

Sci Rep. 2024 01 3;14(1):445

PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2.

Montserrat-Gomez M, Gogl G, Carrasco K, Betzi S, Durbesson F, Cousido-Siah A, Kostmann C, Essig DJ, Strømgaard K, Østergaard S, Morelli X, Trave G, Vincentelli R, Bailly E, Borg JP

Biochim Biophys Acta Proteins Proteom. 2023 12 22;:140989

Comparative analysis of PDZ-binding motifs in the diacylglycerol kinase family.

Zambo B, Gogl G, Morlet B, Eberling P, Negroni L, Moine H, Travé G

FEBS J. 2023 11 9;:

Molecules interact. But how strong and how much?

Weimer K, Zambo B, Gogl G

Bioessays. 2023 06;45(6):e2300007

Native holdup (nHU) to measure binding affinities from cell extracts.

Zambo B, Morlet B, Negroni L, Trave G, Gogl G

Sci Adv. 2022 12 21;8(51):eade3828

Quantitative fragmentomics allow affinity mapping of interactomes.

Gogl G, Zambo B, Kostmann C, Cousido-Siah A, Morlet B, Durbesson F, Negroni L, Eberling P, Jané P, Nominé Y, Zeke A, Østergaard S, Monsellier É, Vincentelli R, Travé G

Nat Commun. 2022 09 17;13(1):5472

Promiscuity mapping of the S100 protein family using a high-throughput holdup assay.

Simon MA, Bartus É, Mag B, Boros E, Roszjár L, Gógl G, Travé G, Martinek TA, Nyitray L

Sci Rep. 2022 Apr 7;12(1):5904

A scalable strategy to solve structures of PDZ domains and their complexes.

Cousido-Siah A, Carneiro L, Kostmann C, Ecsedi P, Nyitray L, Trave G, Gogl G

Acta Crystallogr D Struct Biol. 2022 Apr 1;78(Pt 4):509-516

A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.

Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A

Nat Commun. 2022 01 25;13(1):472

Studying the Structures of Relaxed and Fuzzy Interactions: The Diverse World of S100 Complexes.

Ecsédi P, Gógl G, Nyitray L

Front Mol Biosci. 2021 10 11;8:749052

Host PDZ-containing proteins targeted by SARS-CoV-2.

Caillet-Saguy C, Durbesson F, Rezelj VV, Gogl G, Tran QD, Twizere JC, Vignuzzi M, Vincentelli R, Wolff N

FEBS J. 2021 09;288(17):5148-5162

Characterization of the Intramolecular Interactions and Regulatory Mechanisms of the Scaffold Protein Tks4.

Merő B, Koprivanacz K, Cserkaszky A, Radnai L, Vas V, Kudlik G, Gógl G, Sok P, Póti ÁL, Szeder B, Nyitray L, Reményi A, Geiszt M, Buday L

Int J Mol Sci. 2021 07 28;22(15):

Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.

Gogl G, Tugaeva KV, Eberling P, Kostmann C, Trave G, Sluchanko NN

Nat Commun. 2021 03 15;12(1):1677

Conformational editing of intrinsically disordered protein by α-methylation.

Bauer V, Schmidtgall B, Gógl G, Dolenc J, Osz J, Nominé Y, Kostmann C, Cousido-Siah A, Mitschler A, Rochel N, Travé G, Kieffer B, Torbeev V

Chem Sci. 2020 Nov 4;12(3):1080-1089

Structure of high-risk papillomavirus type 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation.

Conrady MC, Suarez I, Gogl G, Frecot DI, Bonhoure A, Kostmann C, Cousido-Siah A, Mitschler A, Lim J, Masson M, Iftner T, Stubenrauch F, Trave G, Simon C

J Virol. 2020 Oct 28;:

MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.

Sok P, Gógl G, Kumar GS, Alexa A, Singh N, Kirsch K, Sebő A, Drahos L, Gáspári Z, Peti W, Reményi A

Structure. 2020 10 6;28(10):1101-1113.e5

Structure Determination of the Transactivation Domain of p53 in Complex with S100A4 Using Annexin A2 as a Crystallization Chaperone.

Ecsédi P, Gógl G, Hóf H, Kiss B, Harmat V, Nyitray L

Structure. 2020 08 4;28(8):943-953.e4

High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family.

Simon MA, Ecsédi P, Kovács GM, Póti ÁL, Reményi A, Kardos J, Gógl G, Nyitray L

FEBS J. 2020 07;287(13):2834-2846

Benchtop holdup assay for quantitative affinity-based analysis of sequence determinants of protein-motif interactions.

Bonhoure A, Forster A, Babah KO, Gógl G, Eberling P, Kostmann C, Volkmer R, Mancilla VT, Travé G, Nominé Y

Anal. Biochem.. 2020 May 16;:113772

Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.

Parker BW, Gogl G, Bálint M, Hetényi C, Reményi A, Weiss EL

Biochemistry. 2020 05 5;59(17):1688-1700

Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.

Gogl G, Jane P, Caillet-Saguy C, Kostmann C, Bich G, Cousido-Siah A, Nyitray L, Vincentelli R, Wolff N, Nomine Y, Sluchanko NN, Trave G

Structure. 2020 Apr 6;:

Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase.

Jané P, Gógl G, Kostmann C, Bich G, Girault V, Caillet-Saguy C, Eberling P, Vincentelli R, Wolff N, Travé G, Nominé Y

PLoS One. 2020 ;15(12):e0244613

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.

Gógl G, Kornev AP, Reményi A, Taylor SS

Trends Biochem Sci. 2019 04;44(4):300-311

Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.

Merő B, Radnai L, Gógl G, Tőke O, Leveles I, Koprivanacz K, Szeder B, Dülk M, Kudlik G, Vas V, Cserkaszky A, Sipeki S, Nyitray L, Vértessy BG, Buday L

J Biol Chem. 2019 03 22;294(12):4608-4620

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

Gógl G, Biri-Kovács B, Durbesson F, Jane P, Nomine Y, Kostmann C, Bilics V, Simon M, Reményi A, Vincentelli R, Trave G, Nyitray L

J. Mol. Biol.. 2019 Feb 3;:

Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments.

Ecsédi P, Billington N, Pálfy G, Gógl G, Kiss B, Bulyáki É, Bodor A, Sellers JR, Nyitray L

J Biol Chem. 2018 09 21;293(38):14850-14867

Dynamic control of RSK complexes by phosphoswitch-based regulation.

Gógl G, Biri-Kovács B, Póti ÁL, Vadászi H, Szeder B, Bodor A, Schlosser G, Ács A, Turiák L, Buday L, Alexa A, Nyitray L, Reményi A

FEBS J. 2018 01;285(1):46-71

Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.

Ecsédi P, Kiss B, Gógl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vértessy B, Jeszenői N, Hetényi C, Schlosser G, Katona G, Nyitray L

Structure. 2017 08 1;25(8):1195-1207.e5

Ezrin interacts with S100A4 via both its N- and C-terminal domains.

Biri-Kovács B, Kiss B, Vadászi H, Gógl G, Pálfy G, Török G, Homolya L, Bodor A, Nyitray L

PLoS One. 2017 05 11;12(5):e0177489

Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.

Gógl G, Alexa A, Kiss B, Katona G, Kovács M, Bodor A, Reményi A, Nyitray L

J Biol Chem. 2016 01 1;291(1):11-27

The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.

Gógl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetényi C, Reményi A, Weiss EL

PLoS Biol. 2015 05;13(5):e1002146

Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.

Alexa A, Gógl G, Glatz G, Garai Á, Zeke A, Varga J, Dudás E, Jeszenői N, Bodor A, Hetényi C, Reményi A

Proc Natl Acad Sci U S A. 2015 03 3;112(9):2711-6

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