Herr LA, Fiala GJ, Sagar, Schaffer AM, Hummel JF, Zintchenko M, Raute K, Velasco Cárdenas RM, Heizmann B, Ebert K, Fehrenbach K, Janowska I, Chan S, Tanriver Y, Minguet S, Schamel WW

Sci Adv. 2024 03 15;10(11):eadj2802

IKAROS Family Transcription Factors in Lymphocyte Differentiation and Function.

Kastner P, Chan S

Adv Exp Med Biol. 2024 ;1459:33-52

Evolution of the Ikaros family transcription factors: From a deuterostome ancestor to humans.

Kastner P, Aukenova A, Chan S

Biochem Biophys Res Commun. 2023 12 18;694:149399

Ikaros is a principal regulator of Aire mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.

Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR

Sci Immunol. 2023 10 27;8(88):eabq3109

CD4 regulatory T cells lacking Helios and Eos.

Polak K, Marchal P, Taroni C, Ebel C, Kirstetter P, Kastner P, Chan S

Biochem Biophys Res Commun. 2023 06 28;674:83-89

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S

J Exp Med. 2021 Oct 4;218(10):

Ikaros deficiency is associated with aggressive BCR-ABL1 B cell precursor acute lymphoblastic leukemia independent of the lineage and developmental origin.

Simand C, Keime C, Cayé A, Arfeuille C, Passet M, Kim R, Cavé H, Clappier E, Kastner P, Chan S, Heizmann B

Haematologica. 2021 Sep 30;:

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4 T Cells.

Lancien M, Bienvenu G, Salle S, Gueno L, Feyeux M, Merieau E, Remy S, Even A, Moreau A, Molle A, Fourgeux C, Coulon F, Beriou G, Bouchet-Delbos L, Chiffoleau E, Kirstetter P, Chan S, Kerfoot SM, Abdu Rahiman S, De Simone V, Matteoli G, Boncompain G, Perez F, Josien R, Poschmann J, Cuturi MC, Louvet C

J Immunol. 2021 Jul 7;:

CD4 T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate.

Bernardi C, Maurer G, Ye T, Marchal P, Jost B, Wissler M, Maurer U, Kastner P, Chan S, Charvet C

Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):

Ikaros antagonizes DNA binding by STAT5 in pre-B cells.

Heizmann B, Le Gras S, Simand C, Marchal P, Chan S, Kastner P

PLoS One. 2020 ;15(11):e0242211

Large deletions of the 5' region of IKZF1 lead to haploinsufficiency in B-cell precursor acute lymphoblastic leukaemia.

Morel G, Deau MC, Simand C, Caye-Eude A, Arfeuille C, Ittel A, Miguet L, Mauvieux L, Herbrecht R, Paillard C, Strullu M, Cavé H, Chan S, Kastner P, Heizmann B

Br. J. Haematol.. 2019 May 30;:

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.

Mastio J, Simand C, Cova G, Kastner P, Chan S, Kirstetter P

PLoS Genet.. 2018 Jul;14(7):e1007485

Treatment of MCPT8 mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.

El Hachem C, Hener P, Kirstetter P, Li J, Chan S, Li M

Eur. J. Immunol.. 2018 Jan 8;:

The Ikaros family in lymphocyte development.

Heizmann B, Kastner P, Chan S

Curr. Opin. Immunol.. 2017 Dec 23;51:14-23

Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma: A Rare Cancer Network study.

Pellanda AF, De Bari B, Deniaud-Alexandre E, Krengli M, Van Houtte P, Richetti A, Villà S, Goldberg H, Szutowicz-Zielińska E, Bolla M, Rutten H, Van Eijkeren M, Poortmans P, Henke G, Anacak Y, Chan S, Landmann C, Kirkove C, Scandolaro L, Bernier J, Mirimanoff RO, Ozsahin M

Chin. J. Cancer Res.. 2017 Dec;29(6):521-532

Therapeutical modulation of plasmacytoid dendritic cells in experimental arthritis.

Nehmar R, Alsaleh G, Voisin B, Flacher V, Mariotte A, Saferding V, Puchner A, Niederreiter B, Vandamme T, Schabbauer G, Kastner P, Chan S, Kirstetter P, Holcmann M, Mueller C, Sibilia J, Bahram S, Blüml S, Georgel P

. 2017 Aug;:

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.

Martín-Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion-Poll L, Herranz C, Esgleas M, Barriga GG, Edel MJ, Vicario-Abejón C, Alberch J, Girault JA, Chan S, Kastner P, Canals JM

Development. 2017 Mar;:

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.

Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L

Immunity. 2016 Jul;45(1):185-97

Ikaros Is a Negative Regulator of B1 Cell Development and Function.

Macias-Garcia A, Heizmann B, Sellars M, Marchal P, Dali H, Pasquali JL, Muller S, Kastner P, Chan S

J. Biol. Chem.. 2016 Apr;291(17):9073-86

Ikaros limits follicular B cell activation by regulating B cell receptor signaling pathways.

Heizmann B, Sellars M, Macias-Garcia A, Chan S, Kastner P

Biochem. Biophys. Res. Commun.. 2016 Feb;470(3):714-20

Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.

Apostolov A, Litim-Mecheri I, Oravecz A, Goepp M, Kirstetter P, Marchal P, Ittel A, Mauvieux L, Chan S, Kastner P

PLoS ONE. 2016 ;11(6):e0157767

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.

Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H

Science. 2015 Oct 16;350(6258):334-9

Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2.

Oravecz A, Apostolov A, Polak K, Jost B, Le Gras S, Chan S, Kastner P

Nat Commun. 2015 Nov 9;6:8823

The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells.

Geimer Le Lay AS, Oravecz A, Mastio J, Jung C, Marchal P, Ebel C, Dembele D, Jost B, Le Gras S, Thibault C, Borggrefe T, Kastner P, Chan S

Sci Signal. 2014 Mar 18;7(317):ra28

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.

Heizmann B, Kastner P, Chan S

J Exp Med. 2013 Dec 16;210(13):2823-32

beta-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.

Kaveri D, Kastner P, Dembele D, Nerlov C, Chan S, Kirstetter P

Blood. 2013 Aug 1;122(5):694-704

Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations.

Dupuis A, Gaub MP, Legrain M, Drenou B, Mauvieux L, Lutz P, Herbrecht R, Chan S, Kastner P

Leukemia. 2013 Feb;27(2):503-7

Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia.

Kastner P, Dupuis A, Gaub MP, Herbrecht R, Lutz P, Chan S

Am J Blood Res. 2013;3(1):1-13

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.

Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M

Nat Commun. 2013;4:2847

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.

Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C

Nat Immunol. 2012 Oct;13(10):972-80

Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice.

Guillerey C, Mouries J, Polo G, Doyen N, Law HK, Chan S, Kastner P, Leclerc C, Dadaglio G

Blood. 2012 Jul 5;120(1):90-9

Ikaros in B cell development and function.

Sellars M, Kastner P, Chan S

World J Biol Chem. 2011 Jun 26;2(6):132-9

Role of Ikaros in T-cell acute lymphoblastic leukemia.

Kastner P, Chan S

World J Biol Chem. 2011 Jun 26;2(6):108-14

Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.

Serre K, Benezech C, Desanti G, Bobat S, Toellner KM, Bird R, Chan S, Kastner P, Cunningham AF, Maclennan IC, Mohr E

PLoS One. 2011;6(6):e20731

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC

Blood. 2010 Dec 16;116(25):5455-64

Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes.

Kastner P, Chan S, Vogel WK, Zhang LJ, Topark-Ngarm A, Golonzhka O, Jost B, Le Gras S, Gross MK, Leid M

Eur J Immunol. 2010 Aug;40(8):2143-54.

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.

Virely C, Moulin S, Cobaleda C, Lasgi C, Alberdi A, Soulier J, Sigaux F, Chan S, Kastner P, Ghysdael J

Leukemia. 2010 Jun;24(6):1200-4

Genetic inactivation of Ikaros is a rare event in human T-ALL.

Marcais A, Jeannet R, Hernandez L, Soulier J, Sigaux F, Chan S, Kastner P

Leuk Res. 2010 Apr;34(4):426-9

MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.

Sarrazin S, Mossadegh-Keller N, Fukao T, Aziz A, Mourcin F, Vanhille L, Kelly Modis L, Kastner P, Chan S, Duprez E, Otto C, Sieweke MH

Cell. 2009 Jul 23;138(2):300-13.

Ikaros controls isotype selection during immunoglobulin class switch recombination.

Sellars M, Reina-San-Martin B, Kastner P, Chan S

J Exp Med. 2009 May 11;206(5):1073-87

Plasmacytoid dendritic cells are dispensable during primary influenza virus infection.

Wolf AI, Buehler D, Hensley SE, Cavanagh LL, Wherry EJ, Kastner P, Chan S, Weninger W

J Immunol. 2009 Jan 15;182(2):871-9.

Ikaros represses the transcriptional response to Notch signaling in T-cell development.

Kleinmann E, Geimer Le Lay AS, Sellars M, Kastner P, Chan S

Mol Cell Biol. 2008 Dec;28(24):7465-75

PU.1: a crucial and versatile player in hematopoiesis and leukemia.

Kastner P, Chan S

Int J Biochem Cell Biol. 2008;40(1):22-7

Lanthanide complexation with CMPO and CMPO-calix[4]arenes in solution: spectrophotometric and electrospray mass spectrometric approaches.

Herschbach H, Brisach F, Haddaoui J, Saadioui M, Leize E, Van Dorsselaer A, Arnaud-Neu F, Bohmer V

Talanta. 2007 Nov 15;74(1):39-46

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.

Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K

Cell Stem Cell. 2007 Oct 11;1(4):416-27.

[Notch activation during T-cell leukemogenesis in Ikaros-deficient mice].

Kastner P, Chan S

Med Sci (Paris). 2006 Aug-Sep;22(8-9):708-10.

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.

Coste A, Antal MC, Chan S, Kastner P, Mark M, O'Malley BW, Auwerx J

EMBO J. 2006 Jun 7;25(11):2453-64

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.

Delale T, Paquin A, Asselin-Paturel C, Dalod M, Brizard G, Bates EE, Kastner P, Chan S, Akira S, Vicari A, Biron CA, Trinchieri G, Briere F

J Immunol. 2005 Nov 15;175(10):6723-32.