IKAROS Family Transcription Factors in Lymphocyte Differentiation and Function.
Fiche publication
Date publication
janvier 2024
Journal
Advances in experimental medicine and biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHAN Susan, Dr KASTNER Philippe
Tous les auteurs :
Kastner P, Chan S
Lien Pubmed
Résumé
The IKAROS family of transcription factors comprises four zinc-finger proteins (IKAROS, HELIOS, AIOLOS, and EOS), which over the last decades have been established to be critical regulators of the development and function of lymphoid cells. These factors act as homo- or heterodimers and are involved both in gene activation and repression. Their function often involves cross-talk with other regulatory circuits, such as the JAK/STAT, NF-κB, and NOTCH pathways. They control lymphocyte differentiation at multiple stages and are notably critical for lymphoid commitment in multipotent hematopoietic progenitors and for T and B cell differentiation downstream of pre-TCR and pre-BCR signaling. They also control many aspects of effector functions in mature B and T cells. They are dysregulated or mutated in multiple pathologies affecting the lymphoid system, which range from leukemia to immunodeficiencies. In this chapter, we review the molecular and physiological function of these factors in lymphocytes and their implications in human pathologies.
Mots clés
B- and T-cell differentiation, Effector B- and T-cell functions, Ikaros family, Inborn errors of immunity, Leukemia, Stem cells
Référence
Adv Exp Med Biol. 2024 ;1459:33-52