Reversible biomechano-responsive surface based on green fluorescent protein genetically modified with unnatural amino acids.
Fiche publication
Date publication
janvier 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe, Pr SCHAAF Pierre
Tous les auteurs :
Longo J, Yao C, Rios C, Chau NT, Boulmedais F, Hemmerle J, Lavalle P, Schiller SM, Schaaf P, Jierry L
Lien Pubmed
Résumé
GFP has been genetically modified at two specific positions of its molecular architecture. These modifications allow its covalent attachment onto PEG brushes grafted on functionalized silicone surfaces. The stretching of this material leads to a reversible decrease of the fluorescence intensity due to stretch-induced forces applying on GFP molecules.
Référence
Chem Commun (Camb). 2015 Jan 4;51(1):232-5