Regeneration of fat cells from myofibroblasts during wound healing.
Fiche publication
Date publication
février 2017
Journal
Science (New York, N.Y.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHAMBON Pierre, Dr METZGER Daniel
Tous les auteurs :
Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G
Lien Pubmed
Résumé
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro. Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.
Mots clés
Adipocytes, physiology, Animals, Bone Morphogenetic Protein 2, pharmacology, Bone Morphogenetic Protein 4, pharmacology, Bone Morphogenetic Proteins, metabolism, Cells, Cultured, Cellular Reprogramming, Cicatrix, pathology, DNA-Binding Proteins, metabolism, Fibroblasts, pathology, Hair Follicle, physiology, Humans, Mice, Mice, Inbred C57BL, Myofibroblasts, drug effects, Recombinant Proteins, pharmacology, Regeneration, Signal Transduction, Transcription Factors, metabolism, Wound Healing
Référence
Science. 2017 Feb;355(6326):748-752