Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Targeting the liver clock improves fibrosis by restoring TGF-β signaling.

Crouchet E, Dachraoui M, Jühling F, Roehlen N, Oudot MA, Durand SC, Ponsolles C, Gadenne C, Meiss-Heydmann L, Moehlin J, Martin R, Brignon N, Del Zompo F, Teraoka Y, Aikata H, Abe-Chayama H, Chayama K, Saviano A, Heide D, Onea M, Geyer L, Wolf T, Felli E, Pessaux P, Heikenwälder M, Chambon P, Schuster C, Lupberger J, Mukherji A, Baumert TF

J Hepatol. 2024 08 20;:

A high-light therapy restores the circadian clock and corrects the pathological syndrome generated in restricted-fed mice.

Damara M, Misra N, Chambon P

Proc Natl Acad Sci U S A. 2024 08 6;121(32):e2403770121

The circadian demethylation of a unique intronic deoxymethylCpG-rich island boosts the transcription of its cognate circadian clock output gene.

Misra N, Damara M, Ye T, Chambon P

Proc Natl Acad Sci U S A. 2023 02 21;120(8):e2214062120

The HP1α protein is mandatory to repress the circadian clock and its output genes during the 12 h period of transcriptional repression.

Misra N, Damara M, Chambon P

Proc Natl Acad Sci U S A. 2023 02 21;120(8):e2213075120

Retinoic acid receptors at 35 years.

Petkovich M, Chambon P

J Mol Endocrinol. 2022 09 1;:

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Yang P, Tian H, Zou YR, Chambon P, Ichinose H, Honig G, Diamond B, Kim SJ

Front Immunol. 2021 ;12:616583

Phosphorylation site S122 in estrogen receptor α has a tissue-dependent role in female mice.

Ohlsson C, Gustafsson KL, Farman HH, Henning P, Lionikaite V, Movérare-Skrtic S, Sjögren K, Törnqvist AE, Andersson A, Islander U, Bernardi AI, Poutanen M, Chambon P, Lagerquist MK

FASEB J. 2020 Oct 16;:

Mutation of Arginine 264 on ERα (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility.

Adlanmerini M, Chanaelle F, Zahreddine R, Vessières E, Buscato M, Solinhac R, Favre J, Anquetil T, Guihot AL, Boudou F, Raymond-Letron I, Chambon P, Gourdy P, Ohlsson C, Laurell H, Fontaine C, Metivier R, Le Romancer M, Henrion D, Arnal JF, Lenfant F

Arterioscler. Thromb. Vasc. Biol.. 2020 Jul 9;:ATVBAHA120314159

Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids.

Hua G, Zein N, Daubeuf F, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2019 Jun 21;:

The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids.

Hua G, Zein N, Paulen L, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2019 Jun 20;:

Role of RXRbeta in platelet function and arterial thrombosis.

Lüsebrink E, Warm V, Pircher J, Ehrlich A, Zhang Z, Strecker J, Chambon P, Massberg S, Schulz C, Petzold T

J. Thromb. Haemost.. 2019 Jun 7;:

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice.

Oakley RH, Cruz-Topete D, He B, Foley JF, Myers PH, Xu X, Gomez-Sanchez CE, Chambon P, Willis MS, Cidlowski JA

Sci Signal. 2019 Apr 16;12(577):

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality.

Thangavelu G, Lee YC, Loschi M, Schaechter KM, Feser CJ, Koehn BH, Nowak EC, Zeiser R, Serody JS, Murphy WJ, Munn DH, Chambon P, Noelle RJ, Blazar BR

J. Immunol.. 2019 Mar 18;:

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB

Cell Metab.. 2018 Apr 3;27(4):816-827.e4

RORα-expressing T regulatory cells restrain allergic skin inflammation.

Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS

Sci Immunol. 2018 Mar 2;3(21):

Roles of activating functions 1 and 2 of estrogen receptor α in lymphopoiesis.

Andersson A, Törnqvist AE, Moverare-Skrtic S, Bernardi AI, Farman HH, Chambon P, Engdahl C, Lagerquist MK, Windahl SH, Carlsten H, Ohlsson C, Islander U

J. Endocrinol.. 2018 Feb;236(2):99-109

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.

Vieira JM, Howard S, Villa Del Campo C, Bollini S, Dubé KN, Masters M, Barnette DN, Rohling M, Sun X, Hankins LE, Gavriouchkina D, Williams R, Metzger D, Chambon P, Sauka-Spengler T, Davies B, Riley PR

Nat Commun. 2017 Jul;8:16034

Regeneration of fat cells from myofibroblasts during wound healing.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G

Science. 2017 Feb;355(6326):748-752

Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium.

Ganti KP, Mukherji A, Surjit M, Li M, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2017 Feb;114(6):E951-E960

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.

Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, Reber LL, Pirottin D, Kim J, Chambon P, Roers A, Antoine N, Kawakami Y, Kawakami T, Bureau F, Tam SY, Tsai M, Galli SJ

J. Clin. Invest.. 2016 Dec;126(12):4497-4515

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.

Diaz-Castroverde S, Gómez-Hernández A, Fernández S, García-Gómez G, Di Scala M, González-Aseguinolaza G, Fernández-Millán E, González-Rodríguez Á, García-Bravo M, Chambon P, Álvarez C, Perdomo L, Beneit N, Escribano O, Benito M

Dis Model Mech. 2016 Nov;9(11):1271-1281

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW

J. Clin. Invest.. 2016 Sep;126(9):3626

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW

J. Clin. Invest.. 2016 Aug;126(8):3063-79

SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice.

Börjesson AE, Farman HH, Movérare-Skrtic S, Engdahl C, Antal MC, Koskela A, Tuukkanen J, Carlsten H, Krust A, Chambon P, Sjögren K, Lagerquist MK, Windahl SH, Ohlsson C

Am. J. Physiol. Endocrinol. Metab.. 2016 Jun;310(11):E912-8

Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.

Hua G, Ganti KP, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2016 Feb;113(5):E635-43

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.

Hua G, Paulen L, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2016 Feb;113(5):E626-34

Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome.

Mukherji A, Kobiita A, Damara M, Misra N, Meziane H, Champy MF, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2015 Dec;112(48):E6691-8

Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours.

Mukherji A, Kobiita A, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2015 Dec;112(48):E6683-90

Neonatal Estrogen Receptor β Is Important in the Permanent Inhibition of Epithelial Cell Proliferation in the Mouse Uterus.

Nakajima T, Tanimoto Y, Tanaka M, Chambon P, Watanabe H, Iguchi T, Sato T

Endocrinology. 2015 Sep;156(9):3317-28

Protective hematopoietic impact of estrogens in a mouse model of thrombosis: respective roles of nuclear vs membrane estrogen receptor alpha.

Valera MC, Fontaine C, Lenfant F, Cabou C, Guillaume M, Smirnova N, Kim SH, Chambon P, Katzenellenbogen JA, Katzenellenbogen BS, Payrastre B, Arnal JF

Endocrinology. 2015 Aug 17:en20151522.

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu J, O'Malley BW, Mendelson CR

J Clin Invest. 2015 Jul 1;125(7):2808-24

Estrogen receptor KO mice study on rapid modulation of spines and long-term depression in the hippocampus.

Murakami G, Hojo Y, Ogiue-Ikeda M, Mukai H, Chambon P, Nakajima K, Ooishi Y, Kimoto T, Kawato S

Brain Res. 2014 Dec 9. pii: S0006-8993(14)01671-0

Disruption of TGF-beta signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm.

Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W

Biochem Biophys Res Commun. 2014 Nov 7;454(1):137-43

Disruption of TGF-beta signaling in smooth muscle cell prevents flow-induced vascular remodeling.

Gao F, Chambon P, Tellides G, Kong W, Zhang X, Li W

Biochem Biophys Res Commun. 2014 Nov 7;454(1):245-50

Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair.

Campbell L, Emmerson E, Williams H, Saville CR, Krust A, Chambon P, Mace KA, Hardman MJ

J Invest Dermatol. 2014 Sep;134(9):2447-57

Luminal cells are favored as the cell of origin for prostate cancer.

Wang ZA, Toivanen R, Bergren SK, Chambon P, Shen MM

Cell Rep. 2014 Sep 11;8(5):1339-46

Effects of neuron-specific estrogen receptor (ER) alpha and ERbeta deletion on the acute estrogen negative feedback mechanism in adult female mice.

Cheong RY, Porteous R, Chambon P, Abraham I, Herbison AE

Endocrinology. 2014 Apr;155(4):1418-27

Molecular characterization of 39 de novo sSMC: contribution to prognosis and genetic counselling, a prospective study.

Marle N, Martinet D, Aboura A, Joly-Helas G, Andrieux J, Flori E, Puechberty J, Vialard F, Sanlaville D, Fert Ferrer S, Bourrouillou G, Tabet AC, Quilichini B, Simon-Bouy B, Bazin A, Becker M, Stora H, Amblard S, Doco-Fenzy M, Molina Gomes D, Girard-Lemaire F, Cordier MP, Satre V, Schneider A, Lemeur N, Chambon P, Jacquemont S, Fellmann F, Vigouroux-Castera A, Molignier R, Delaye A, Pipiras E, Liquier A, Rousseau T, Mosca AL, Kremer V, Payet M, Rangon C, Mugneret F, Aho S, Faivre L, Callier P

Clin Genet. 2014 Mar;85(3):233-44

Absence of intestinal PPARgamma aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway.

Kundu P, Ling TW, Korecka A, Li Y, D'Arienzo R, Bunte RM, Berger T, Arulampalam V, Chambon P, Mak TW, Wahli W, Pettersson S

PLoS Pathog. 2014 Jan;10(1):e1003887

History of retinoic acid receptors.

Benbrook DM, Chambon P, Rochette-Egly C, Asson-Batres MA

Subcell Biochem. 2014;70:1-20

Mutation of the palmitoylation site of estrogen receptor alpha in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessieres E, Kim SH, Liere P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90

p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells.

Mardaryev AN, Gdula MR, Yarker JL, Emelianov VN, Poterlowicz K, Sharov AA, Sharova TY, Scarpa JA, Chambon P, Botchkarev VA, Fessing MY

Development. 2014 Jan;141(1):101-11

The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.

Engdahl C, Borjesson AE, Forsman HF, Andersson A, Stubelius A, Krust A, Chambon P, Islander U, Ohlsson C, Carlsten H, Lagerquist MK

Arthritis Res Ther. 2014 Jul 15;16(4):R150

Prevention of obesity and insulin resistance by estrogens requires ERalpha activation function-2 (ERalphaAF-2), whereas ERalphaAF-1 is dispensable.

Handgraaf S, Riant E, Fabre A, Waget A, Burcelin R, Liere P, Krust A, Chambon P, Arnal JF, Gourdy P

Diabetes. 2013 Dec;62(12):4098-108

Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner.

Holik AZ, Krzystyniak J, Young M, Richardson K, Jarde T, Chambon P, Shorning BY, Clarke AR

Stem Cells. 2013 Nov;31(11):2457-66

HIF1alpha is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis.

Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson RS, Kato S, Toyama Y, Miyamoto T

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16568-73

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure.

Raison D, Coquard C, Hochane M, Steger J, Massfelder T, Moulin B, Karaplis AC, Metzger D, Chambon P, Helwig JJ, Barthelmebs M

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F333-42

Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs.

Mukherji A, Kobiita A, Ye T, Chambon P

Cell. 2013 May 9;153(4):812-27

The role of activation functions 1 and 2 of estrogen receptor-alpha for the effects of estradiol and selective estrogen receptor modulators in male mice.

Borjesson AE, Farman HH, Engdahl C, Koskela A, Sjogren K, Kindblom JM, Stubelius A, Islander U, Carlsten H, Antal MC, Krust A, Chambon P, Tuukkanen J, Lagerquist MK, Windahl SH, Ohlsson C

J Bone Miner Res. 2013 May;28(5):1117-26

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.

Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A

Nat Immunol. 2013 Mar;14(3):230-7

Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.

Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y

Endocrinology. 2013 Mar;154(3):1008-20

Estrogen receptor-alpha is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2.

Windahl SH, Saxon L, Borjesson AE, Lagerquist MK, Frenkel B, Henning P, Lerner UH, Galea GL, Meakin LB, Engdahl C, Sjogren K, Antal MC, Krust A, Chambon P, Lanyon LE, Price JS, Ohlsson C

J Bone Miner Res. 2013 Feb;28(2):291-301

Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.

Szatkowski C, Vallet J, Dormishian M, Messaddeq N, Valet P, Boulberdaa M, Metzger D, Chambon P, Nebigil CG

PLoS One. 2013 Dec 4;8(12):e81175

Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5.

Cottet S, Juttner R, Voirol N, Chambon P, Rathjen FG, Schorderet DF, Escher P

Mol Vis. 2013 Nov 16;19:2312-20. eCollection 2013.

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.

Nadra K, Medard JJ, Mul JD, Han GS, Gres S, Pende M, Metzger D, Chambon P, Cuppen E, Saulnier-Blache JS, Carman GM, Desvergne B, Chrast R

Mol Cell Biol. 2012 Dec;32(23):4794-810

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

Boj SF, van Es JH, Huch M, Li VS, Jose A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H

Cell. 2012 Dec 21;151(7):1595-607

Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERalpha cross talk.

Emmerson E, Campbell L, Davies FC, Ross NL, Ashcroft GS, Krust A, Chambon P, Hardman MJ

J Invest Dermatol. 2012 Dec;132(12):2838-48

Estrogen dependent activation function of ER beta is essential for the sexual behavior of mouse females.

Antal MC, Petit-Demouliere B, Meziane H, Chambon P, Krust A

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19822-7

PPARbeta/delta affects pancreatic beta cell mass and insulin secretion in mice.

Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, Rutter GA, Prentki M, Thorens B, Wahli W

J Clin Invest. 2012 Nov 1;122(11):4105-17

Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium.

Mori M, Gargowitsch L, Bornert JM, Garnier JM, Mark M, Chambon P, Metzger D

Genesis. 2012 Nov;50(11):828-32

Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.

Raverdeau M, Gely-Pernot A, Feret B, Dennefeld C, Benoit G, Davidson I, Chambon P, Mark M, Ghyselinck NB

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16582-7

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ

Nat Med. 2012 Sep;18(9):1429-33.

Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.

Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP

Haematologica. 2012 Aug;97(8):1131-5

Stromal estrogen receptor-alpha promotes tumor growth by normalizing an increased angiogenesis.

Pequeux C, Raymond-Letron I, Blacher S, Boudou F, Adlanmerini M, Fouque MJ, Rochaix P, Noel A, Foidart JM, Krust A, Chambon P, Brouchet L, Arnal JF, Lenfant F

Cancer Res. 2012 Jun 15;72(12):3010-9

The role of estrogen receptor-alpha and its activation function-1 for growth plate closure in female mice.

Borjesson AE, Windahl SH, Karimian E, Eriksson EE, Lagerquist MK, Engdahl C, Antal MC, Krust A, Chambon P, Savendahl L, Ohlsson C

Am J Physiol Endocrinol Metab. 2012 Jun;302(11):E1381-9

The role of estrogen receptor alpha and beta in regulating vascular smooth muscle cell proliferation is based on sex.

Hogg ME, Vavra AK, Banerjee MN, Martinez J, Jiang Q, Keefer LK, Chambon P, Kibbe MR

J Surg Res. 2012 Mar;173(1):e1-10

Estrogen receptor-alpha expression in neuronal cells affects bone mass.

Ohlsson C, Engdahl C, Borjesson AE, Windahl SH, Studer E, Westberg L, Eriksson E, Koskela A, Tuukkanen J, Krust A, Chambon P, Carlsten H, Lagerquist MK

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):983-8

From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause.

Arnal JF, Lenfant F, Flouriot G, Tremollieres F, Laurell H, Fontaine C, Krust A, Chambon P, Gourdy P

Br J Pharmacol. 2012 Jan;165(1):57-66

Involvement of gonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries in neonatally diethylstilbestrol-treated mice.

Kakuta H, Tanaka M, Chambon P, Watanabe H, Iguchi T, Sato T

Reprod Toxicol. 2012 Jan;33(1):35-44

The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells.

Woldt E, Terrand J, Mlih M, Matz RL, Bruban V, Coudane F, Foppolo S, El Asmar Z, Chollet ME, Ninio E, Bednarczyk A, Thierse D, Schaeffer C, Van Dorsselaer A, Boudier C, Wahli W, Chambon P, Metzger D, Herz J, Boucher P

Nat Commun. 2012;3:1077

TRIM INVOLVEMENT IN TRANSCRIPTIONAL REGULATION.

Cammas F, Khetchoumian K, Chambon P, Losson R

Adv Exp Med Biol. 2012;770:59-76.

Aggravated TSLP-induced atopic dermatitis in mice lacking Dicer in adult skin keratinocytes.

Hener P, Friedmann L, Metzger D, Chambon P, Li M

J Invest Dermatol. 2011 Nov;131(11):2324-7

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.

Liu J, Pascal LE, Isharwal S, Metzger D, Ramos Garcia R, Pilch J, Kasper S, Williams K, Basse PH, Nelson JB, Chambon P, Wang Z

Mol. Endocrinol.. 2011 Nov;25(11):1849-57

Identification of estradiol/ERalpha-regulated genes in the mouse pituitary.

Kim HJ, Gieske MC, Trudgen KL, Hudgins-Spivey S, Kim BG, Krust A, Chambon P, Jeong JW, Blalock E, Ko C

J Endocrinol. 2011 Sep;210(3):309-21

Tripartite motif 24 (Trim24/Tif1alpha) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor alpha (Raralpha) inhibition

Tisserand J, Khetchoumian K, Thibault C, Dembele D, Chambon P, Losson R

J Biol Chem. 2011 Sep 23;286(38):33369-79

Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.

Billon-Gales A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6

Hypoxia-inducible transcription factor 2alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.

Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM

Hepatology. 2011 Aug;54(2):472-83

Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription.

Toth K, Sarang Z, Scholtz B, Brazda P, Ghyselinck N, Chambon P, Fesus L, Szondy Z

Cell Death Differ. 2011 May;18(5):783-92

Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice.

Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W

Biol Psychiatry. 2011 Apr 15;69(8):788-94

Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

Borjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Moverare-Skrtic S, Sjogren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6288-93

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor.

Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, Li M, Chambon P

Cell. 2011 Apr 15;145(2):224-41.

Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.

Takahashi S, Watanabe T, Okada M, Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, Kato S

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4938-43

Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1.

Della Torre S, Rando G, Meda C, Stell A, Chambon P, Krust A, Ibarra C, Magni P, Ciana P, Maggi A

Cell Metab. 2011 Feb 2;13(2):205-14.

Genetic rescue of nonclassical ERalpha signaling normalizes energy balance in obese Eralpha-null mutant mice.

Park CJ, Zhao Z, Glidewell-Kenney C, Lazic M, Chambon P, Krust A, Weiss J, Clegg DJ, Dunaif A, Jameson JL, Levine JE

J Clin Invest. 2011 Feb 1;121(2):604-12

TIF1beta association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.

Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, Cammas F

Dev Biol. 2011 Feb 15;350(2):548-58

Chromatin remodelling complex dosage modulates transcription factor function in heart development.

Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguin P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG

Nat Commun. 2011 Feb 8;2:187

Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse.

Metzger D, Chambon P

Curr Protoc Mouse Biol. 2011 Mar 1;1(1):55-70

Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications.

Yadav VK, Oury F, Tanaka K, Thomas T, Wang Y, Cremers S, Hen R, Krust A, Chambon P, Karsenty G

J Exp Med. 2011 Jan 17;208(1):41-52

Retinoid X receptor gamma signaling accelerates CNS remyelination.

Huang JK, Jarjour AA, Oumesmar BN, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Evercooren AB, Chambon P, Ffrench-Constant C, Franklin RJ

Nat Neurosci. 2011 Jan;14(1):45-53

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.

Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A

Nat Commun. 2011;2:269.

The role of estrogen receptor alpha in growth plate cartilage for longitudinal bone growth.

Borjesson AE, Lagerquist MK, Liu C, Shao R, Windahl SH, Karlsson C, Sjogren K, Moverare-Skrtic S, Antal MC, Krust A, Mohan S, Chambon P, Savendahl L, Ohlsson C

J Bone Miner Res. 2010 Dec;25(12):2414-24

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

Duteil D, Chambon C, Ali F, Malivindi R, Zoll J, Kato S, Geny B, Chambon P, Metzger D

Cell Metab. 2010 Nov 3;12(5):496-508.

Differential involvement of insulin-like growth factor-I and estrogen on prolactin cells in the mouse anterior pituitary.

Hikake T, Hayashi S, Chambon P, Watanabe H, Iguchi T, Sato T

Exp Biol Med (Maywood). 2010 Aug;235(8):974-80

Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities.

Campbell L, Emmerson E, Davies F, Gilliver SC, Krust A, Chambon P, Ashcroft GS, Hardman MJ

J Exp Med. 2010 Aug 30;207(9):1825-33

Myocytic androgen receptor controls the strength but not the mass of limb muscles.

Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P, Metzger D

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14327-32

Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.

Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S

Development. 2010 Aug 1;137(15):2571-8

17beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha.

Gilliver SC, Emmerson E, Campbell L, Chambon P, Hardman MJ, Ashcroft GS

Am J Pathol. 2010 Jun;176(6):2707-21

Epididymal hypo-osmolality induces abnormal sperm morphology and function in the estrogen receptor alpha knockout mouse.

Joseph A, Shur BD, Ko C, Chambon P, Hess RA

Biol Reprod. 2010 May;82(5):958-67

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.

Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA

Oncogene. 2010 May 20;29(20):2950-61

Epidermal gammadelta T cells sense precancerous cellular dysregulation and initiate immune responses.

Shimura E, Hozumi N, Kanagawa O, Metzger D, Chambon P, Radtke F, Hirose S, Nakano N

Int Immunol. 2010 Apr;22(4):329-40

Thymic stromal lymphopoietin (TSLP) and the atopic march

Chambon P

Rev Fr Allergol. 2010 Apr;50(3):94-7

Jarid2 and PRC2, partners in regulating gene expression.

Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D

Genes Dev. 2010 Feb 15;24(4):368-80

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su DM

J Biol Chem. 2010 Feb 19;285(8):5836-47

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.

He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A

Epigenetics Chromatin. 2010 Nov 30;3(1):21.

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice.

Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K

PLoS One. 2010 Jun 23;5(6):e11275.

Non-cell-autonomous retinoid signaling is crucial for renal development.

Rosselot C, Spraggon L, Chia I, Batourina E, Riccio P, Lu B, Niederreither K, Dolle P, Duester G, Chambon P, Costantini F, Gilbert T, Molotkov A, Mendelsohn C

Development. 2010 Jan;137(2):283-92.

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.

Chorro L, Sarde A, Li M, Woollard KJ, Chambon P, Malissen B, Kissenpfennig A, Barbaroux JB, Groves R, Geissmann F

J Exp Med. 2009 Dec 21;206(13):3089-100

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.

Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Bjorklund A, Ichinose H, Perlmann T

J Neurosci. 2009 Dec 16;29(50):15923-32.

Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries.

Kim H, Nakajima T, Hayashi S, Chambon P, Watanabe H, Iguchi T, Sato T

Biol Reprod. 2009 Nov;81(5):1002-9

Involvement of estrogen receptor beta in the induction of polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol.

Kirigaya A, Kim H, Hayashi S, Chambon P, Watanabe H, Lguchi T, Sato T

Zoolog Sci. 2009 Oct;26(10):704-12.

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction.

Leclerc EA, Huchenq A, Mattiuzzo NR, Metzger D, Chambon P, Ghyselinck NB, Serre G, Jonca N, Guerrin M

J Cell Sci. 2009 Aug 1;122(Pt 15):2699-709

Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely.

Lee S, Kang DW, Hudgins-Spivey S, Krust A, Lee EY, Koo Y, Cheon Y, Gye MC, Chambon P, Ko C

Endocrinology. 2009 Aug;150(8):3855-62

Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2.

Modder UI, Monroe DG, Fraser DG, Spelsberg TC, Rosen CJ, Gehin M, Chambon P, O'Malley BW, Khosla S

J Biol Chem. 2009 Jul 10;284(28):18767-77

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CW, Knudsen ES

Mol Biol Cell. 2009 Jul;20(14):3192-9

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.

Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK

J Invest Dermatol. 2009 Jun;129(6):1459-70

p21-Activated kinase mediates rapid estradiol-negative feedback actions in the reproductive axis.

Zhao Z, Park C, McDevitt MA, Glidewell-Kenney C, Chambon P, Weiss J, Jameson JL, Levine JE

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7221-6

Retinoic Acid Can Directly Promote TGF-beta-Mediated Foxp3(+) Treg Cell Conversion of Naive T Cells Response to Letter from Mucida et al.

Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C

Immunity. 2009 Apr 17;30(4):472-3

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M

Dev Biol. 2009 Apr 15;328(2):315-27

A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.

Mascrez B, Ghyselinck NB, Chambon P, Mark M

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4272-7

Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin.

Li M, Hener P, Zhang Z, Ganti KP, Metzger D, Chambon P

J Invest Dermatol. 2009 Feb;129(2):498-502

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.

Billon-Gales A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2053-8

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.

Zhang Z, Hener P, Frossard N, Kato S, Metzger D, Li M, Chambon P

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1536-41

Effects of diethylstilbestrol on ovarian follicle development in neonatal mice.

Kim H, Hayashi S, Chambon P, Watanabe H, Iguchi T, Sato T

Reprod Toxicol. 2009 Jan;27(1):55-62

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse.

Wendling O, Bornert JM, Chambon P, Metzger D

Genesis. 2009 Jan;47(1):14-8.

Function of retinoic acid receptors during embryonic development.

Mark M, Ghyselinck NB, Chambon P

Nucl Recept Signal. 2009;7:e002

Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network.

Toutain CE, Brouchet L, Raymond-Letron I, Vicendo P, Berges H, Favre J, Fouque MJ, Krust A, Schmitt AM, Chambon P, Gourdy P, Arnal JF, Lenfant F

Circ Res. 2009 Jan 30;104(2):245-54, 12p following 254

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C

Immunity. 2008 Nov;29(5):758-70.

STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.

Mark M, Jacobs H, Oulad-Abdelghani M, Dennefeld C, Feret B, Vernet N, Codreanu CA, Chambon P, Ghyselinck NB

J Cell Sci. 2008 Oct 1;121(Pt 19):3233-42.

Clinical phenotype of germline RUNX1 haploinsufficiency: from point mutations to large genomic deletions.

Beri-Dexheimer M, Latger-Cannard V, Philippe C, Bonnet C, Chambon P, Roth V, Gregoire MJ, Bordigoni P, Lecompte T, Leheup B, Jonveaux P

Eur J Hum Genet. 2008 Aug;16(8):1014-8

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

Mandillo S, Tucci V, Holter SM, Meziane H, Banchaabouchi MA, Kallnik M, Lad HV, Nolan PM, Ouagazzal AM, Coghill EL, Gale K, Golini E, Jacquot S, Krezel W, Parker A, Riet F, Schneider I, Marazziti D, Auwerx J, Brown SD, Chambon P, Rosenthal N, Tocchini-Valentini G, Wurst W

Physiol Genomics. 2008 Aug 15;34(3):243-55

Functional alterations of the nigrostriatal dopamine system in estrogen receptor-alpha knockout (ERKO) mice.

Kuppers E, Krust A, Chambon P, Beyer C

Psychoneuroendocrinology. 2008 Jul;33(6):832-8

Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue.

Konishi M, Nakamura H, Miwa H, Chambon P, Ornitz DM, Itoh N

Mol Cell Endocrinol. 2008 Jun 11;287(1-2):13-9

Modular patterning of structure and function of the striatum by retinoid receptor signaling.

Liao WL, Tsai HC, Wang HF, Chang J, Lu KM, Wu HL, Lee YC, Tsai TF, Takahashi H, Wagner M, Ghyselinck NB, Chambon P, Liu FC

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6765-70

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, Huber M, Hohl D, Cano A, Birchmeier W, Huelsken J

Nature. 2008 Apr 3;452(7187):650-3.

Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production.

Douin-Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, Gourdy P, Arnal JF, Guery JC

J Immunol. 2008 Mar 15;180(6):3661-9.

Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.

Ignat M, Teletin M, Tisserand J, Khetchoumian K, Dennefeld C, Chambon P, Losson R, Mark M

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2598-603

Efficient, inducible Cre-recombinase activation in vascular endothelium.

Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K, Fruttiger M

Genesis. 2008 Feb;46(2):74-80.

Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy.

Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2646-51

Sterility and absence of histopathological defects in nonreproductive organs of a mouse ER beta-null mutant

Antal MC, Krust A, Chambon P, Mark M

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2433-8

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.

Ratnacaram CK, Teletin M, Jiang M, Meng X, Chambon P, Metzger D

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2521-6

Pituitary gonadotroph estrogen receptor-alpha is necessary for fertility in females.

Gieske MC, Kim HJ, Legan SJ, Koo Y, Krust A, Chambon P, Ko C

Endocrinology. 2008 Jan;149(1):20-7

Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary.

Kim HJ, Gieske MC, Hudgins S, Kim BG, Krust A, Chambon P, Ko C

J Endocrinol. 2007 Dec;195(3):393-405.

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.

Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M, Zucman-Rossi J, Cammas F, Lerouge T, Thibault C, Metzger D, Chambon P, Losson R

Nat. Genet.. 2007 Dec;39(12):1500-6

Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage.

Ruiz A, Ghyselinck NB, Mata N, Nusinowitz S, Lloyd M, Dennefeld C, Chambon P, Bok D

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5377-87.

TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation.

Klopcic B, Maass T, Meyer E, Lehr HA, Metzger D, Chambon P, Mann A, Blessing M

Eur J Cell Biol. 2007 Dec;86(11-12):781-99

Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism.

Cederroth CR, Schaad O, Descombes P, Chambon P, Vassalli JD, Nef S

Endocrinology. 2007 Nov;148(11):5507-19

Estrogen response element-independent estrogen receptor (ER)-alpha signaling does not rescue sexual behavior but restores normal testosterone secretion in male ERalpha knockout mice.

McDevitt MA, Glidewell-Kenney C, Weiss J, Chambon P, Jameson JL, Levine JE

Endocrinology. 2007 Nov;148(11):5288-94

Transgenic mice for conditional gene manipulation in astroglial cells.

Slezak M, Goritz C, Niemiec A, Frisen J, Chambon P, Metzger D, Pfrieger FW

Glia. 2007 Nov 15;55(15):1565-76.

Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice.

MacLean G, Li H, Metzger D, Chambon P, Petkovich M

Endocrinology. 2007 Oct;148(10):4560-7

Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.

Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S

Cell. 2007 Sep;130(5):811-23

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.

Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA

Nat Neurosci. 2007 Jul;10(7):880-6

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.

Walkley CR, Olsen GH, Dworkin S, Fabb SA, Swann J, McArthur GA, Westmoreland SV, Chambon P, Scadden DT, Purton LE

Cell. 2007 Jun 15;129(6):1097-110.

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

Dali-Youcef N, Mataki C, Coste A, Messaddeq N, Giroud S, Blanc S, Koehl C, Champy MF, Chambon P, Fajas L, Metzger D, Schoonjans K, Auwerx J

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10703-8

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

Berry A, Balard P, Coste A, Olagnier D, Lagane C, Authier H, Benoit-Vical F, Lepert JC, Seguela JP, Magnaval JF, Chambon P, Metzger D, Desvergne B, Wahli W, Auwerx J, Pipy B

Eur J Immunol. 2007 Jun;37(6):1642-52.

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P

J Invest Dermatol. 2007 May;127(5):1250-60

Effects of loss of classical estrogen response element signaling on bone in male mice.

Syed FA, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S

Endocrinology. 2007 Apr;148(4):1902-10

CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.

Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y

Dev Biol. 2007 Feb 15;302(2):399-411

Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons

Mukai H, Tsurugizawa T, Murakami G, Kominami S, Ishii H, Ogiue-Ikeda M, Takata N, Tanabe N, Furukawa A, Hojo Y, Ooishi Y, Morrison JH, Janssen WGM, Rose JA, Chambon P, Kato S, Izumi S, Yamazaki T, Kimoto T, Kawato S

J Neurochem. 2007 Feb;100(4):950-67.

Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma.

Dzhagalov I, Chambon P, He YW

J Immunol. 2007 Feb 15;178(4):2113-21.

[Microarray-based comparative genomic hybridization in the study of constitutional chromosomal abnormalities]

Beri-Dexheimer M, Bonnet C, Chambon P, Brochet K, Gregoire MJ, Jonveaux P

Pathol Biol (Paris). 2007 Feb;55(1):13-8

Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.

Metzger D, Chambon P

Handb Exp Pharmacol. 2007;(178):511-24.

Inducible Cre/loxP recombination in the mouse proximal tubule.

Dworniczak B, Skryabin B, Tchinda J, Heuck S, Seesing FJ, Metzger D, Chambon P, Horst J, Pennekamp P

Nephron Exp Nephrol. 2007;106(1):e11-20

Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice.

Patchev AV, Fischer D, Wolf SS, Herkenham M, Gotz F, Gehin M, Chambon P, Patchev VK, Almeida OF

FASEB J. 2007 Jan;21(1):231-8

International Union of Pharmacology. LX. Retinoic acid receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H

Pharmacol Rev. 2006 Dec;58(4):712-25.

International Union of Pharmacology. LXIII. Retinoid X receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H

Pharmacol Rev. 2006 Dec;58(4):760-72.

Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.

Vernet N, Dennefeld C, Guillou F, Chambon P, Ghyselinck NB, Mark M

EMBO J. 2006 Dec 13;25(24):5816-25

PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes.

Schuler M, Ali F, Chambon C, Duteil D, Bornert JM, Tardivel A, Desvergne B, Wahli W, Chambon P, Metzger D

Cell Metab. 2006 Nov;4(5):407-14.

Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.

Oskarsson T, Essers MA, Dubois N, Offner S, Dubey C, Roger C, Metzger D, Chambon P, Hummler E, Beard P, Trumpp A

Genes Dev.. 2006 Aug;20(15):2024-9

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.

Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.

Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P

Genes Dev. 2006 Jun 1;20(11):1525-38.

A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis.

Qiu J, Bosch MA, Tobias SC, Krust A, Graham SM, Murphy SJ, Korach KS, Chambon P, Scanlan TS, Ronnekleiv OK, Kelly MJ

J Neurosci. 2006 May 24;26(21):5649-55.

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.

Purton LE, Dworkin S, Olsen GH, Walkley CR, Fabb SA, Collins SJ, Chambon P

J Exp Med. 2006 May 15;203(5):1283-93

Temporal regulation of Cre recombinase activity in neural stem cells.

Imayoshi I, Ohtsuka T, Metzger D, Chambon P, Kageyama R

Genesis. 2006 May;44(5):233-8.

Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2).

Vermot J, Garnier JM, Dierich A, Niederreither K, Harvey RP, Chambon P, Dolle P

Genesis. 2006 Mar;44(3):155-8.

Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.

Desai TJ, Chen F, Lu J, Qian J, Niederreither K, Dolle P, Chambon P, Cardoso WV

Dev Biol. 2006 Mar 1;291(1):12-24

Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.

Sharma V, Hays WR, Wood WM, Pugazhenthi U, St Germain DL, Bianco AC, Krezel W, Chambon P, Haugen BR

Endocrinology. 2006 Mar;147(3):1438-51

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis.

Stratis A, Pasparakis M, Markur D, Knaup R, Pofahl R, Metzger D, Chambon P, Krieg T, Haase I

J Invest Dermatol. 2006 Mar;126(3):614-20.

Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland.

Mallepell S, Krust A, Chambon P, Brisken C

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2196-201

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

Nenci A, Huth M, Funteh A, Schmidt-Supprian M, Bloch W, Metzger D, Chambon P, Rajewsky K, Krieg T, Haase I, Pasparakis M

Hum Mol Genet. 2006 Feb 15;15(4):531-42

The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor.

Watanabe H, Takahashi E, Kobayashi M, Goto M, Krust A, Chambon P, Iguchi T

J Mol Endocrinol. 2006 Feb;36(1):81-9.

Brg1 is required for murine neural stem cell maintenance and gliogenesis.

Matsumoto S, Banine F, Struve J, Xing R, Adams C, Liu Y, Metzger D, Chambon P, Rao MS, Sherman LS

Dev Biol. 2006 Jan 15;289(2):372-83

Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis.

Mark M, Ghyselinck NB, Chambon P

Annu Rev Pharmacol Toxicol. 2006;46:451-80.

Premature ovarian failure in androgen receptor-deficient mice.

Shiina H, Matsumoto T, Sato T, Igarashi K, Miyamoto J, Takemasa S, Sakari M, Takada I, Nakamura T, Metzger D, Chambon P, Kanno J, Yoshikawa H, Kato S

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):224-9

Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis.

Vernet N, Dennefeld C, Rochette-Egly C, Oulad-Abdelghani M, Chambon P, Ghyselinck NB, Mark M

Endocrinology. 2006 Jan;147(1):96-110

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease.

Li XG, Okada T, Kodera M, Nara Y, Takino N, Muramatsu C, Ikeguchi K, Urano F, Ichinose H, Metzger D, Chambon P, Nakano I, Ozawa K, Muramatsu S

Mol. Ther.. 2006 Jan;13(1):160-6

Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency.

Herrmann T, Grone HJ, Langbein L, Kaiser I, Gosch I, Bennemann U, Metzger D, Chambon P, Stewart AF, Stremmel W

J Invest Dermatol. 2005 Dec;125(6):1228-35.

Mouse phenogenomics: the fast track to "systems metabolism".

Argmann CA, Chambon P, Auwerx J

Cell Metab. 2005 Dec;2(6):349-60.

Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells.

Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB

Development. 2005 Nov;132(21):4789-800

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways.

Syed FA, Modder UI, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S

J Bone Miner Res. 2005 Nov;20(11):1992-2001

Letter regarding article by Korte et al, "Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction" - Response.

Korte T, Fuchs M, Arkudas A, Geertz S, Gardiwal A, Klein G, Niehaus M, Meyer R, Fink K, Krust A, Chambon P, Grohe C

Circulation. 2005 Oct 18;112(16):E272.

Retinoic acid signaling affects cortical synchrony during sleep.

Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P, Tafti M

Science. 2005 Oct 7;310(5745):111-3.

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

Li M, Messaddeq N, Teletin M, Pasquali JL, Metzger D, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2005 Oct;102(41):14795-800

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.

Indra AK, Dupe V, Bornert JM, Messaddeq N, Yaniv M, Mark M, Chambon P, Metzger D

Development. 2005 Oct;132(20):4533-44.

Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms.

Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Hakansson H

Chem Biol Interact. 2005 Sep 10;156(1):25-39.

Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.

Martin M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dolle P, Gradwohl G

Dev Biol. 2005 Aug 15;284(2):399-411.

Functional role of RXRs and PPARgamma in mature adipocytes.

Metzger D, Imai T, Jiang M, Takukawa R, Desvergne B, Wahli W, Chambon P

Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):51-8.

The nuclear receptor superfamily: a personal retrospect on the first two decades.

Chambon P

Mol Endocrinol. 2005 Jun;19(6):1418-28.

Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development.

Matt N, Schmidt CK, Dupe V, Dennefeld C, Nau H, Chambon P, Mark M, Ghyselinck NB

Dev Dyn. 2005 May;233(1):167-76.

Estrogen receptor-alpha is associated with the plasma membrane of astrocytes and coupled to the MAP/Src-kinase pathway.

Pawlak J, Karolczak M, Krust A, Chambon P, Beyer C

Glia. 2005 May;50(3):270-5.

Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction.

Korte T, Fuchs M, Arkudas A, Geertz S, Meyer R, Gardiwal A, Klein G, Niehaus M, Krust A, Chambon P, Drexler H, Fink K, Grohe C

Circulation. 2005 May 10;111(18):2282-90

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.

Schnutgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7221-6

Working memory deficits in retinoid X receptor gamma-deficient mice.

Wietrzych M, Meziane H, Sutter A, Ghyselinck N, Chapman PF, Chambon P, Krezel W

Learn Mem. 2005 May-Jun;12(3):318-26

Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal.

Martinez-Ceballos E, Chambon P, Gudas LJ

J Biol Chem. 2005 Apr 22;280(16):16484-98

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.

Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, Tempst P, de Murcia G, Evans R, Chambon P, Reinberg D

Mol Cell. 2005 Apr 1;18(1):83-96.

Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons.

Vermot J, Schuhbaur B, Le Mouellic H, McCaffery P, Garnier JM, Hentsch D, Brulet P, Niederreither K, Chambon P, Dolle P, Le Roux I

Development. 2005 Apr;132(7):1611-21.

Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo.

Vermot J, Gallego Llamas J, Fraulob V, Niederreither K, Chambon P, Dolle P

Science. 2005 Apr 22;308(5721):563-6

Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon.

Liao WL, Wang HF, Tsai HC, Chambon P, Wagner M, Kakizuka A, Liu FC

Dev Dyn. 2005 Apr;232(4):887-900.

Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse.

Schuler M, Ali F, Metzger E, Chambon P, Metzger D

Genesis. 2005 Apr;41(4):165-70.

Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation.

Serpente P, Tumpel S, Ghyselinck NB, Niederreither K, Wiedemann LM, Dolle P, Chambon P, Krumlauf R, Gould AP

Development. 2005 Feb;132(3):503-13

Targeted somatic mutagenesis in the mouse epidermis.

Metzger D, Li M, Chambon P

Methods Mol Biol. 2005;289:329-40.

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC

Genes Dev.. 2004 Dec;18(24):2998-3003

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.

Khetchoumian K, Teletin M, Mark M, Lerouge T, Cerviño M, Oulad-Abdelghani M, Chambon P, Losson R

J. Biol. Chem.. 2004 Nov;279(46):48329-41

Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action.

Rieusset J, Seydoux J, Anghel SI, Escher P, Michalik L, Soon Tan N, Metzger D, Chambon P, Wahli W, Desvergne B

Mol. Endocrinol.. 2004 Oct;18(10):2363-77

Mouse functional genomics requires standardization of mouse handling and housing conditions.

Champy MF, Selloum M, Piard L, Zeitler V, Caradec C, Chambon P, Auwerx J

Mamm Genome. 2004 Oct;15(10):768-83.

Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation.

Cammas F, Herzog M, Lerouge T, Chambon P, Losson R

Genes Dev.. 2004 Sep;18(17):2147-60

The European dimension for the mouse genome mutagenesis program.

Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Muller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W

Nat Genet. 2004 Sep;36(9):925-7.

Retinoid X receptor gamma-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet.

Haugen BR, Jensen DR, Sharma V, Pulawa LK, Hays WR, Krezel W, Chambon P, Eckel RH

Endocrinology. 2004 Aug;145(8):3679-85

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse.

Schuler M, Dierich A, Chambon P, Metzger D

Genesis. 2004 Jul;39(3):167-72

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium.

el Marjou F, Janssen KP, Chang BH, Li M, Hindie V, Chan L, Louvard D, Chambon P, Metzger D, Robine S

Genesis. 2004 Jul;39(3):186-93

Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene.

Yan KP, Dollé P, Mark M, Lerouge T, Wendling O, Chambon P, Losson R

Gene. 2004 Jun;334:3-13

Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif.

Nielsen AL, Jørgensen P, Lerouge T, Cerviño M, Chambon P, Losson R

Mol. Cell. Biol.. 2004 Jun;24(12):5184-96

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.

Andl T, Ahn K, Kairo A, Chu EY, Wine-Lee L, Reddy ST, Croft NJ, Cebra-Thomas JA, Metzger D, Chambon P, Lyons KM, Mishina Y, Seykora JT, Crenshaw EB, Millar SE

Development. 2004 May;131(10):2257-68

In vivo activation of PPAR target genes by RXR homodimers.

IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B

EMBO J.. 2004 May;23(10):2083-91

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.

Mascrez B, Ghyselinck NB, Watanabe M, Annicotte JS, Chambon P, Auwerx J, Mark M

EMBO Rep. 2004 Mar;5(3):285-90.

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Imai T, Takakuwa R, Marchand S, Dentz E, Bornert JM, Messaddeq N, Wendling O, Mark M, Desvergne B, Wahli W, Chambon P, Metzger D

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4543-7

Brain masculinization requires androgen receptor function.

Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K, Fukuda T, Aihara K, Krust A, Yamada T, Nakamichi Y, Yamamoto Y, Nakamura T, Yoshimura K, Yoshizawa T, Metzger D, Chambon P, Kato S

Proc. Natl. Acad. Sci. U.S.A.. 2004 Feb;101(6):1673-8

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

Mori M, Metzger D, Picaud S, Hindelang C, Simonutti M, Sahel J, Chambon P, Mark M

Am. J. Pathol.. 2004 Feb;164(2):701-10

Hedgehog signaling regulates sebaceous gland development.

Allen M, Grachtchouk M, Sheng H, Grachtchouk V, Wang A, Wei L, Liu J, Ramirez A, Metzger D, Chambon P, Jorcano J, Dlugosz AA

Am. J. Pathol.. 2003 Dec;163(6):2173-8

Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development.

Chi TH, Wan M, Lee PP, Akashi K, Metzger D, Chambon P, Wilson CB, Crabtree GR

Immunity. 2003 Aug;19(2):169-82

Suppressive function of androgen receptor in bone resorption.

Kawano H, Sato T, Yamada T, Matsumoto T, Sekine K, Watanabe T, Nakamura T, Fukuda T, Yoshimura K, Yoshizawa T, Aihara K, Yamamoto Y, Nakamichi Y, Metzger D, Chambon P, Nakamura K, Kawaguchi H, Kato S

Proc. Natl. Acad. Sci. U.S.A.. 2003 Aug;100(16):9416-21

NSD1 is essential for early post-implantation development and has a catalytically active SET domain.

Rayasam GV, Wendling O, Angrand PO, Mark M, Niederreither K, Song L, Lerouge T, Hager GL, Chambon P, Losson R

EMBO J.. 2003 Jun;22(12):3153-63

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.

Menissier de Murcia J, Ricoul M, Tartier L, Niedergang C, Huber A, Dantzer F, Schreiber V, Ame JC, Dierich A, LeMeur M, Sabatier L, Chambon P, de Murcia G

EMBO J. 2003 May 1;22(9):2255-63.

Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.

Abu-Abed S, Dollé P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M

Development. 2003 Apr;130(7):1449-59

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells.

Leone DP, Genoud S, Atanasoski S, Grausenburger R, Berger P, Metzger D, Macklin WB, Chambon P, Suter U

Mol. Cell. Neurosci.. 2003 Apr;22(4):430-40

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis.

Weber P, Schuler M, Gérard C, Mark M, Metzger D, Chambon P

Biol. Reprod.. 2003 Feb;68(2):553-9

Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.

Metzger D, Indra AK, Li M, Chapellier B, Calleja C, Ghyselinck NB, Chambon P

Methods Enzymol. 2003;364:379-408.

Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha.

Nielsen AL, Sanchez C, Ichinose H, Cerviño M, Lerouge T, Chambon P, Losson R

EMBO J.. 2002 Nov;21(21):5797-806

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

Chapellier B, Mark M, Messaddeq N, Calléja C, Warot X, Brocard J, Gérard C, Li M, Metzger D, Ghyselinck NB, Chambon P

EMBO J.. 2002 Jul;21(13):3402-13

Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse.

Weber P, Cammas F, Gerard C, Metzger D, Chambon P, Losson R, Mark M

Development. 2002 May;129(10):2329-37

Site-specific somatic mutagenesis in the retinal pigment epithelium.

Mori M, Metzger D, Garnier JM, Chambon P, Mark M

Invest. Ophthalmol. Vis. Sci.. 2002 May;43(5):1384-8

[Genetic dissection of retinoic acid function in epidermis physiology].

Ghyselinck NB, Chapellier B, Calléja C, Kumar Indra A, Li M, Messaddeq N, Mark M, Metzger D, Chambon P

Ann Dermatol Venereol. 2002 May;129(5 Pt 2):793-9

Aberrant growth plate development in VDR/RXR gamma double null mutant mice.

Yagishita N, Yamamoto Y, Yoshizawa T, Sekine K, Uematsu Y, Murayama H, Nagai Y, Krezel W, Chambon P, Matsumoto T, Kato S

Endocrinology. 2001 Dec;142(12):5332-41

Temporally controlled targeted somatic mutagenesis in the mouse brain.

Weber P, Metzger D, Chambon P

Eur. J. Neurosci.. 2001 Dec;14(11):1777-83

Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.

Krezel W, Dupont S, Krust A, Chambon P, Chapman PF

Proc. Natl. Acad. Sci. U.S.A.. 2001 Oct;98(21):12278-82

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.

Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W

J. Cell Biol.. 2001 Aug;154(4):799-814

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.

Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H, Aster JC, Krishna S, Metzger D, Chambon P, Miele L, Aguet M, Radtke F, Dotto GP

EMBO J.. 2001 Jul;20(13):3427-36

Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha.

Mascrez B, Mark M, Krezel W, Dupé V, LeMeur M, Ghyselinck NB, Chambon P

Development. 2001 Jun;128(11):2049-62

Site- and time-specific gene targeting in the mouse.

Metzger D, Chambon P

Methods. 2001 May;24(1):71-80

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.

Imai T, Jiang M, Kastner P, Chambon P, Metzger D

Proc. Natl. Acad. Sci. U.S.A.. 2001 Apr;98(8):4581-6

RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.

Li M, Chiba H, Warot X, Messaddeq N, Gérard C, Chambon P, Metzger D

Development. 2001 Mar;128(5):675-88

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives.

Vallier L, Mancip J, Markossian S, Lukaszewicz A, Dehay C, Metzger D, Chambon P, Samarut J, Savatier P

Proc. Natl. Acad. Sci. U.S.A.. 2001 Feb;98(5):2467-72

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.

Imai T, Jiang M, Chambon P, Metzger D

Proc. Natl. Acad. Sci. U.S.A.. 2001 Jan;98(1):224-8

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.

Abu-Abed S, Dollé P, Metzger D, Beckett B, Chambon P, Petkovich M

Genes Dev.. 2001 Jan;15(2):226-40

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, Randazzo F, Metzger D, Chambon P, Crabtree G, Magnuson T

Mol. Cell. 2000 Dec;6(6):1287-95

F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression.

Chiba H, Chambon P, Metzger D

Exp. Cell Res.. 2000 Nov;260(2):334-9

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis.

Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P

Nature. 2000 Oct;407(6804):633-6

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene.

Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, Wahli W

J. Biol. Chem.. 2000 Sep;275(37):28488-93

Temporally controlled somatic mutagenesis in smooth muscle.

Kühbandner S, Brummer S, Metzger D, Chambon P, Hofmann F, Feil R

Genesis. 2000 Sep;28(1):15-22

Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse.

Brown NS, Smart A, Sharma V, Brinkmeier ML, Greenlee L, Camper SA, Jensen DR, Eckel RH, Krezel W, Chambon P, Haugen BR

J. Clin. Invest.. 2000 Jul;106(1):73-9

Inducible site-specific somatic mutagenesis in mouse hepatocytes.

Imai T, Chambon P, Metzger D

Genesis. 2000 Feb;26(2):147-8

Targeted somatic mutagenesis in mouse epidermis.

Indra AK, Li M, Brocard J, Warot X, Bornert JM, Gérard C, Messaddeq N, Chambon P, Metzger D

Horm. Res.. 2000 ;54(5-6):296-300

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.

Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, Metzger D

Nucleic Acids Res.. 1999 Nov;27(22):4324-7

Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex.

Delva L, Bastie JN, Rochette-Egly C, Kraïba R, Balitrand N, Despouy G, Chambon P, Chomienne C

Mol. Cell. Biol.. 1999 Oct;19(10):7158-67

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.

Niederreither K, Subbarayan V, Dolle P, Chambon P

Nat Genet. 1999 Apr;21(4):444-8.

Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain.

Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM

Neuron. 1999 Apr;22(4):677-91.

Differential expression of retinoid receptors in the adult mouse central nervous system.

Krezel W, Kastner P, Chambon P

Neuroscience. 1999 ;89(4):1291-300

A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor.

Brocard J, Feil R, Chambon P, Metzger D

Nucleic Acids Res.. 1998 Sep;26(17):4086-90

Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.

Barros AC, Erway LC, Krezel W, Curran T, Kastner P, Chambon P, Forrest D

Neuroreport. 1998 Sep;9(13):2933-7

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators.

Huang N, vom Baur E, Garnier JM, Lerouge T, Vonesch JL, Lutz Y, Chambon P, Losson R

EMBO J.. 1998 Jun;17(12):3398-412

Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.

Krezel W, Ghyselinck N, Samad TA, Dupé V, Kastner P, Borrelli E, Chambon P

Science. 1998 Feb;279(5352):863-7

Mesectoderm is a major target of retinoic acid action.

Mark M, Ghyselinck NB, Kastner P, Dupé V, Wendling O, Krezel W, Mascrez B, Chambon P

Eur. J. Oral Sci.. 1998 Jan;106 Suppl 1:24-31

Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.

Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D, Chambon P, Petkovich M

J. Biol. Chem.. 1998 Jan;273(4):2409-15

Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.

Samad TA, Krezel W, Chambon P, Borrelli E

Proc. Natl. Acad. Sci. U.S.A.. 1997 Dec;94(26):14349-54

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

Brocard J, Warot X, Wendling O, Messaddeq N, Vonesch JL, Chambon P, Metzger D

Proc. Natl. Acad. Sci. U.S.A.. 1997 Dec;94(26):14559-63

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

Chiba H, Clifford J, Metzger D, Chambon P

J. Cell Biol.. 1997 Nov;139(3):735-47

SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells.

Sumi-Ichinose C, Ichinose H, Metzger D, Chambon P

Mol. Cell. Biol.. 1997 Oct;17(10):5976-86

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.

Feil R, Wagner J, Metzger D, Chambon P

Biochem. Biophys. Res. Commun.. 1997 Aug;237(3):752-7

Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.

Chiba H, Clifford J, Metzger D, Chambon P

Mol. Cell. Biol.. 1997 Jun;17(6):3013-20

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.

Kastner P, Mark M, Ghyselinck N, Krezel W, Dupé V, Grondona JM, Chambon P

Development. 1997 Jan;124(2):313-26

Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.

Rochel N, Renaud JP, Ruff M, Vivat V, Granger F, Bonnier D, Lerouge T, Chambon P, Gronemeyer H, Moras D

Biochem. Biophys. Res. Commun.. 1997 Jan;230(2):293-6

[Genetic control of the development by retinoic acid].

Mark M, Kastner P, Ghyselinck NB, Krezel W, Dupé V, Chambon P

C. R. Seances Soc. Biol. Fil.. 1997 ;191(1):77-90

Ligand-activated site-specific recombination in mice.

Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 1996 Oct;93(20):10887-90

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

Krezel W, Dupé V, Mark M, Dierich A, Kastner P, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 1996 Aug;93(17):9010-4

RXRalpha-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids.

Clifford J, Chiba H, Sobieszczuk D, Metzger D, Chambon P

EMBO J.. 1996 Aug;15(16):4142-55

Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells.

Metzger D, Ali S, Bornert JM, Chambon P

J. Biol. Chem.. 1995 Apr;270(16):9535-42

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

Berry M, Metzger D, Chambon P

EMBO J.. 1990 Sep;9(9):2811-8

Characterization of multiple mRNAs originating from the chicken progesterone receptor gene. Evidence for a specific transcript encoding form A.

Jeltsch JM, Turcotte B, Garnier JM, Lerouge T, Krozowski Z, Gronemeyer H, Chambon P

J. Biol. Chem.. 1990 Mar;265(7):3967-74

Pr CHAMBON Pierre

Fiche personne

coordonnées

Territoire

Statut

affiliation

équipes/plateformes

Recherche

Publications