Thymic stromal lymphopoietin (TSLP) and the atopic march
Fiche publication
Date publication
avril 2010
Lien Pubmed
Résumé
Ample dermatitis (AD) is often the initial step in an "atopic march," given that more than half of AD patients with moderate to severe AD develop asthma later in life Both AD and asthma share a similar "atopy" phenotype that includes a T helper type 2 in with eosinophilia and hyper-IgE immunoglobulinemia, but the molecular and cellular mechanisms underlying the atopic march remain elusive In the present study, we show that the induced expression of the cytokine Thymic Stromal Lymphoporetin (TSLP) in mouse epidermal keratinocytes. upon topical application of MC903 (a low calcemic analogue of vitamin D3), not only triggers AD, as we previously reported. but also aggravates an experimental allergic asthma induced by ovalbumin sensitization and challenge Our study, which provides a mouse model to study the human atopic march. indicates that keratinocyte-produced TSLP may represent an important factor in the process which leads from atopic dermatitis to asthma (C) 2010 Published by Elsevier Masson SAS
Référence
Rev Fr Allergol. 2010 Apr;50(3):94-7