Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA.
Fiche publication
Date publication
février 2019
Journal
British journal of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRASSART-PASCO Sylvie, Pr MICHEL Jean, Dr MONBOISSE Jean-Claude, Pr RAMONT Laurent, Dr TERRYN Christine, Dr VELARD Frédéric, Dr BRASSART Bertrand
Tous les auteurs :
Brassart B, Da Silva J, Donet M, Seurat E, Hague F, Terryn C, Velard F, Michel J, Ouadid-Ahidouch H, Monboisse JC, Hinek A, Maquart FX, Ramont L, Brassart-Pasco S
Lien Pubmed
Résumé
Carcinogenesis occurs in elastin-rich tissues and leads to local inflammation and elastolytic proteinase release. This contributes to bioactive matrix fragment (Matrikine) accumulation like elastin degradation products (EDP) stimulating tumour cell invasive and metastatic properties. We previously demonstrate that EDPs exert protumoural activities through Hsp90 secretion to stabilised extracellular proteinases.
Référence
Br. J. Cancer. 2019 Feb 11;: