Altered thymic CD4 T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.
Fiche publication
Date publication
juin 2019
Journal
Current research in translational medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERCEANU Ana, Pr DECONINCK Eric, Dr FERRAND Christophe, Dr LAROSA Fabrice, Pr SEILLES Estelle, Dr DAGUINDAU Etienne, Dr POUTHIER Fabienne
Tous les auteurs :
Roussel X, Daguindau E, Berceanu A, Desbrosses Y, Saas P, Ferrand C, Seilles E, Pouthier F, Deconinck E, Larosa F
Lien Pubmed
Résumé
Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4 T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated immunity recovery for patients presenting a nocardiosis compared to a control cohort.
Mots clés
Allogeneic hematopoietic stem cell transplant, Immune recovery, Nocardia, Opportunistic infection, Thymic CD4(+)T-cell
Référence
Curr Res Transl Med. 2019 Jun 1;: