Dissecting Gene Repression: Not Just Location, Location, Location.
Fiche publication
Date publication
juin 2019
Journal
Trends in cell biology
Lien Pubmed
Résumé
Large heterochromatic domains are found tethered to the lamina. But, is this nuclear environment repressive per se, or just the 'ground state' of inactive chromatin? Elegant studies from the van Steensel group (Leemans et al., Cell, 2019) recently demonstrated that the lamina is indeed repressive, but that intrinsic promoter properties also dictate gene activity.
Mots clés
gene repression, lamina-associated domain, promoter transplantation
Référence
Trends Cell Biol.. 2019 Jun 21;: