Taylor T, Sikorska N, Shchuka VM, Chahar S, Ji C, Macpherson NN, Moorthy SD, de Kort MAC, Mullany S, Khader N, Gillespie ZE, Langroudi L, Tobias IC, Lenstra TL, Mitchell JA, Sexton T

Genes Dev. 2022 06 16;:

The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes.

Recoules L, Heurteau A, Raynal F, Karasu N, Moutahir F, Bejjani F, Jariel-Encontre I, Cuvier O, Sexton T, Lavigne AC, Bystricky K

J Cell Sci. 2022 Apr 1;:

Concurrent CDX2 cis-deregulation and UBTF-ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.

Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye-Eude A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay TT, Hunault-Berger MM, Pflumio F, Freund JN, Lobry C, Lheritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E

Blood. 2022 Mar 22;:

Precise measurements of chromatin diffusion dynamics by modeling using Gaussian processes.

Oliveira GM, Oravecz A, Kobi D, Maroquenne M, Bystricky K, Sexton T, Molina N

Nat Commun. 2021 Oct 26;12(1):6184

Myod1 and GR coordinate myofiber-specific transcriptional enhancers.

Rovito D, Rerra AI, Ueberschlag-Pitiot V, Joshi S, Karasu N, Dacleu-Siewe V, Rayana KB, Ghaibour K, Parisotto M, Ferry A, Jelinsky SA, Laverny G, Klaholz BP, Sexton T, Billas IML, Duteil D, Metzger D

Nucleic Acids Res. 2021 Apr 9;:

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.

Alcalá-Vida R, Seguin J, Lotz C, Molitor AM, Irastorza-Azcarate I, Awada A, Karasu N, Bombardier A, Cosquer B, Skarmeta JLG, Cassel JC, Boutillier AL, Sexton T, Merienne K

Nat Commun. 2021 01 13;12(1):364

4C-Seq: Interrogating Chromatin Looping with Circular Chromosome Conformation Capture.

Karasu N, Sexton T

Methods Mol. Biol.. 2021 ;2157:19-34

Assessment of 3D Interactions Between Promoters and Distal Regulatory Elements with Promoter Capture Hi-C (PCHi-C).

Karasu N, Sexton T

Methods Mol Biol. 2021 ;2351:229-248

Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation.

Maqbool MA, Pioger L, El Aabidine AZ, Karasu N, Molitor AM, Dao LTM, Charbonnier G, van Laethem F, Fenouil R, Koch F, Lacaud G, Gut I, Gut M, Amigorena S, Joffre O, Sexton T, Spicuglia S, Andrau JC

Cell Rep. 2020 Aug 18;32(7):108048

Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.

Alomairi J, Molitor AM, Sadouni N, Hussain S, Torres M, Saadi W, Dao LTM, Charbonnier G, Santiago-Algarra D, Andrau JC, Puthier D, Sexton T, Spicuglia S

PLoS ONE. 2020 ;15(5):e0233191

Defining functionally relevant spatial chromatin domains: it's a TAD complicated.

Sikorska N, Sexton T

J. Mol. Biol.. 2019 Dec 18;:

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.

Pal K, Forcato M, Jost D, Sexton T, Vaillant C, Salviato E, Mazza EMC, Lugli E, Cavalli G, Ferrari F

Nat Commun. 2019 Nov 25;10(1):5355

Dissecting Gene Repression: Not Just Location, Location, Location.

Sexton T

Trends Cell Biol.. 2019 Jun 21;:

ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C.

Ben Zouari Y, Molitor AM, Sikorska N, Pancaldi V, Sexton T

Genome Biol.. 2019 May 22;20(1):102

4See: A Flexible Browser to Explore 4C Data.

Ben Zouari Y, Platania A, Molitor AM, Sexton T

Front Genet. 2019 ;10:1372

Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions.

Cattoni DI, Cardozo Gizzi AM, Georgieva M, Di Stefano M, Valeri A, Chamousset D, Houbron C, Déjardin S, Fiche JB, González I, Chang JM, Sexton T, Marti-Renom MA, Bantignies F, Cavalli G, Nollmann M

Nat Commun. 2017 11 24;8(1):1753

Dr SEXTON Thomas

Fiche personne

coordonnées

Territoire

Statut

affiliation

équipes/plateformes

Projets

Décrypter le remodelage chromatinien des cellules souches cancéreuses mammaires en réponse aux inhibiteurs de BET : Identification de nouvelles cibles thérapeutiques pour les cancers du sein triples négatifs

Décrypter le remodelage chromatinien des cellules souches cancéreuses mammaires en réponse aux inhibiteurs de BET : Identification de nouvelles cibles thérapeutiques pour les cancers du sein triples négatifs

Organisation fonctionnelle et spatiale de la chromatine pendant le développement des lymphocytes T et dans la leucémie

Publications

Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation.

Transcription induces context-dependent remodeling of chromatin architecture during differentiation.

RNA polymerase II CTD is dispensable for transcription and required for termination in human cells.

Short tandem repeats are important contributors to silencer elements in T cells.

Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the locus.