Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains.
Fiche publication
Date publication
août 2015
Journal
BMC genomics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SEXTON Thomas
Tous les auteurs :
Ea V, Sexton T, Gostan T, Herviou L, Baudement MO, Zhang Y, Berlivet S, Le Lay-Taha MN, Cathala G, Lesne A, Victor JM, Fan Y, Cavalli G, Forné T
Lien Pubmed
Résumé
In higher eukaryotes, the genome is partitioned into large "Topologically Associating Domains" (TADs) in which the chromatin displays favoured long-range contacts. While a crumpled/fractal globule organization has received experimental supports at higher-order levels, the organization principles that govern chromatin dynamics within these TADs remain unclear. Using simple polymer models, we previously showed that, in mouse liver cells, gene-rich domains tend to adopt a statistical helix shape when no significant locus-specific interaction takes place.
Mots clés
Animals, Chromatin, chemistry, Chromatin Assembly and Disassembly, DNA, chemistry, Drosophila melanogaster, genetics, Epigenesis, Genetic, Liver, metabolism, Mice, Models, Molecular, Models, Statistical, Mouse Embryonic Stem Cells, cytology, Nucleic Acid Conformation
Référence
BMC Genomics. 2015 Aug 15;16:607