Chromosome folding: driver or passenger of epigenetic state?
Fiche publication
Date publication
février 2015
Journal
Cold Spring Harbor perspectives in biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SEXTON Thomas
Tous les auteurs :
Sexton T, Yaffe E
Lien Pubmed
Résumé
Despite a growing understanding of how epigenetic marks such as histone modifications locally modify the activity of the chromatin with which they are associated, we know little about how marked regions on different parts of the genome are able to intercommunicate to effect regulation of gene expression programs. Recent advances in methods that systematically map pairwise chromatin interactions have uncovered important principles of chromosome folding, which are tightly linked to the epigenetic mark profiles and, hence, functional state of the underlying chromatin fiber.
Mots clés
Animals, Chromatin Assembly and Disassembly, Chromosomes, chemistry, Epigenomics, Gene Expression Regulation
Référence
Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a018721