Persistence of lymphocyte function perturbations after granulocyte-colony-stimulating factor mobilization and cytapheresis in normal peripheral blood stem cell donors.
Fiche publication
Date publication
décembre 2010
Journal
Transfusion
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DECONINCK Eric, Dr LAROSA Fabrice, Dr POUTHIER Fabienne
Tous les auteurs :
Marmier-Savet C, Larosa F, Legrand F, Witz B, Michallet M, Ranta D, Louvat P, Puyraveau M, Raus N, Tavernier M, Mathieu-Nafissi S, Hequet O, Pouthier F, Deconinck E, Tiberghien P, Robinet E
Lien Pubmed
Résumé
The short-term effects of granulocyte-colony-stimulating factor (G-CSF) have been extensively studied, but recent reports of G-CSF-induced genetic perturbations raised concerns regarding its long-term safety. In this respect, duration of G-CSF-induced perturbations has been less studied than short-term effects and needs to be evaluated.
Mots clés
Adult, Blood Donors, Cell Movement, drug effects, Female, Follow-Up Studies, Granulocyte Colony-Stimulating Factor, adverse effects, Hematopoietic Stem Cell Mobilization, adverse effects, Hematopoietic Stem Cells, drug effects, Humans, Immune System Diseases, blood, Leukapheresis, methods, Lymphocytes, drug effects, Male, Middle Aged, Recombinant Proteins, Recovery of Function, immunology, Time Factors, Young Adult
Référence
Transfusion. 2010 Dec;50(12):2676-85