Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients.
Fiche publication
Date publication
mars 2021
Journal
The American journal of clinical nutrition
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis, Dr OUSSALAH Abderrahim
Tous les auteurs :
Levy J, Rodriguez-Guéant RM, Oussalah A, Jeannesson E, Wahl D, Ziuly S, Guéant JL
Lien Pubmed
Résumé
The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin supplementation to lowering homocysteine. Consequently, the results of interventional studies have confused the debate regarding the management of patients with intermediate/severe HHcy.
Mots clés
1-carbon metabolism, cardiovascular disease risk, folate, homocysteine, inborn errors of metabolism, thromboembolic manifestations, vitamin B12
Référence
Am J Clin Nutr. 2021 Mar 10;: