Small Annexin V-Positive Platelet-Derived Microvesicles Affect Prognosis in Cirrhosis: A Longitudinal Study.
Fiche publication
Date publication
avril 2021
Journal
Clinical and translational gastroenterology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent, Mme LAHEURTE Caroline
Tous les auteurs :
Weil D, Di Martino V, Mourey G, Biichle S, Renaudin A, Laheurte C, Cypriani B, Delabrousse E, Grandclément E, Thévenot T, Saas P,
Lien Pubmed
Résumé
Microvesicles (MVs) with procoagulant properties may favor liver parenchymal extinction, then cirrhosis-related complications and mortality. In a longitudinal cohort of cirrhotic patients, we measured plasma levels of platelet-derived MVs (PMVs), endothelial-derived MVs, and red blood cell-derived MVs, expressing phosphatidylserine (annexin V-positive [AV+]) or not, and evaluated their impact on Model for End-Stage Liver Disease (MELD) score and transplant-free survival.
Référence
Clin Transl Gastroenterol. 2021 Apr 28;12(5):e00333