Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers.
Fiche publication
Date publication
septembre 2021
Journal
Clinical epigenetics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis, Dr HOULGATTE Rémy, Pr JANKOWSKI Roger, Pr GAUCHOTTE Guillaume, Dr OUSSALAH Abderrahim, Pr GALLET Patrice
Tous les auteurs :
Gallet P, Oussalah A, Pouget C, Dittmar G, Chery C, Gauchotte G, Jankowski R, Gueant JL, Houlgatte R
Lien Pubmed
Résumé
Nasal intestinal-type adenocarcinomas (ITAC) are strongly related to chronic wood dust exposure: The intestinal phenotype relies on CDX2 overexpression but underlying molecular mechanisms remain unknown. Our objectives were to investigate transcriptomic and methylation differences between healthy non-exposed and tumor olfactory cleft mucosae and to compare transcriptomic profiles between non-exposed, wood dust-exposed and ITAC mucosa cells.
Mots clés
CACNA1C, CDX2, Metaplasia, SLC26A10, Wood dust exposure
Référence
Clin Epigenetics. 2021 Sep 25;13(1):179