Towards the elaboration of new gold-based optical theranostics.
Fiche publication
Date publication
mars 2015
Journal
Dalton transactions (Cambridge, England : 2003)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali, Dr DUBREZ Laurence, Pr PAUL Catherine, Pr DENAT Franck, Dr GONCALVES Victor, Dr DECREAU Richard
Tous les auteurs :
Doulain PE, Decréau R, Racoeur C, Goncalves V, Dubrez L, Bettaieb A, Le Gendre P, Denat F, Paul C, Goze C, Bodio E
Lien Pubmed
Résumé
Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.
Mots clés
Biological Transport, Bombesin, metabolism, Boron Compounds, chemistry, Cell Line, Tumor, Gold, chemistry, Humans, Microscopy, Fluorescence, Optical Imaging, methods, Organometallic Compounds, chemistry
Référence
Dalton Trans. 2015 Mar;44(11):4874-83