Dynamized ultra-low dilution of disrupts plasma membrane organization and decreases migration of melanoma cancer cell.
Fiche publication
Date publication
décembre 2023
Journal
Cell adhesion & migration
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARTINY Laurent, Dr TERRYN Christine, Dr SCHNEIDER Christophe, Dr BERQUAND Alexandre
Tous les auteurs :
Fuselier C, Dufay E, Berquand A, Terryn C, Bonnomet A, Molinari M, Martiny L, Schneider C
Lien Pubmed
Résumé
Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of leads to an inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination . These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in and models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of and reinforce its interest as complementary medicine in oncology.
Mots clés
Melanoma, cancer, dynamized ultra-low dilution, migration, plasma membrane
Référence
Cell Adh Migr. 2023 12;17(1):1-13