Synthesis, In Silico Log Study, and In Vitro Analgesic Activity of Analogs of Tetrapeptide FELL.
Fiche publication
Date publication
août 2023
Journal
Pharmaceuticals (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GERARD Stéphane, Dr COCHARD Marie
Tous les auteurs :
Borisova B, Nocheva H, Gérard S, Laronze-Cochard M, Dobrev S, Angelova S, Petrin S, Danalev D
Lien Pubmed
Résumé
The inflammatory process represents a specific response of the organism's immune system. More often, it is related to the rising pain in the affected area. Independently of its origin, pain represents a complex and multidimensional acute or chronic subjective unpleasant perception. Currently, medical doctors prescribe various analgesics for pain treatment, but unfortunately, many of them have adverse effects or are not strong enough to suppress the pain. Thus, the search for new pain-relieving medical drugs continues.
Mots clés
FELL analogs, analgesic activity, paw-pressure test, peptide synthesis
Référence
Pharmaceuticals (Basel). 2023 08 21;16(8):