MicroRNAs miR-16 and miR-519 control meningioma cell proliferation overlapping transcriptomic programs shared with the RNA-binding protein HuR.
Fiche publication
Date publication
août 2023
Journal
Frontiers in oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis, Dr HOULGATTE Rémy, Pr VIGNAUD Jean-Michel, Pr GAUCHOTTE Guillaume, Dr OUSSALAH Abderrahim, Dr BATTAGLIA-HSU Shyue-Fang, Dr RECH Fabien
Tous les auteurs :
Hergalant S, Casse JM, Oussalah A, Houlgatte R, Helle D, Rech F, Vallar L, Guéant JL, Vignaud JM, Battaglia-Hsu SF, Gauchotte G
Lien Pubmed
Résumé
Meningiomas are the most common type of primary central nervous system tumors. In about 80% cases, these tumors are benign and grow very slowly, but the remainder 20% can unlock higher proliferation rates and become malignant. In this study we examined two miRs, miR-16 and miR-519, and evaluated their role in tumorigenesis and cell growth in human meningioma.
Mots clés
HuR, meningioma, miR-16, miR-519, microRNA, proliferation, transcriptomics, tumorigenesis
Référence
Front Oncol. 2023 08 2;13:1158773