Photofunctional nanomodulators for bioexcitation.
Fiche publication
Date publication
novembre 2014
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MENARD-MOYON Cécilia, Dr BIANCO Alberto
Tous les auteurs :
Miyako E, Russier J, Mauro M, Cebrian C, Yawo H, Ménard-Moyon C, Hutchison JA, Yudasaka M, Iijima S, De Cola L, Bianco A
Lien Pubmed
Résumé
A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.
Mots clés
biological activity, laser chemistry, nanomaterials, nanotechnology
Référence
Angew Chem Int Ed Engl. 2014 Nov 24;53(48):13121-5