Cooperation Between Platelet β1 and β3 Integrins in the Arrest of Bleeding Under Inflammatory Conditions in Mice.
Fiche publication
Date publication
août 2024
Journal
Arteriosclerosis, thrombosis, and vascular biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MANGIN Pierre
Tous les auteurs :
Janus-Bell E, Receveur N, Mercier L, Mouriaux C, Magnenat S, Reiser J, Lanza F, Hechler B, Ho-Tin-Noé B, Mangin PH
Lien Pubmed
Résumé
Platelets prevent bleeding in a variety of inflammatory settings, the adhesion receptors and activation pathways involved being highly context-dependent and functionally redundant. In some situations, platelets recruited to inflammatory sites act independently of aggregation. The mechanisms underlying stable platelet adhesion in inflamed microvessels remain incompletely understood, in particular, whether and if so, how β1 and β3 integrins are involved.
Mots clés
brain ischemia, hemostasis, inflammation, middle cerebral artery, pneumonia
Référence
Arterioscler Thromb Vasc Biol. 2024 08 15;: