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HIV-1 Gag Compact Form stabilized by Intramolecular Interactions is crucial for Infectious Particle Production.

Zeiger M, Pires M, Didier P, Vauchelles R, Mély Y, Boutant E, Real E

J Mol Biol. 2024 06 3;:168639

PvdL Orchestrates the Assembly of the Nonribosomal Peptide Synthetases Involved in Pyoverdine Biosynthesis in .

Manko H, Steffan T, Gasser V, Mély Y, Schalk I, Godet J

Int J Mol Sci. 2024 05 30;25(11):

Integrase-LEDGF/p75 complex triggers the formation of biomolecular condensates that modulate HIV-1 integration efficiency in vitro.

Batisse C, Lapaillerie D, Humbert N, Real E, Zhu R, Mély Y, Parissi V, Ruff M, Batisse J

J Biol Chem. 2024 05 16;:107374

UHRF1 poly-auto-ubiquitination induced by the anti-cancer drug, thymoquinone, is involved in the DNA repair machinery recruitment.

Almalki NAR, Sabir JSM, Ibrahim A, Alhosin M, Asseri AH, Albiheyri RS, Zari AT, Bahieldin A, Javed A, Mély Y, Hamiche A, Mousli M, Bronner C

Int J Biochem Cell Biol. 2024 04 20;:106582

Using lipid binding proteins and advanced microscopy to study lipid domains.

Tomishige N, Takahashi K, Pollet B, Richert L, Mély Y, Kobayashi T

Methods Enzymol. 2024 04 10;700:217-234

Spectral Phasor Applied to Spectrally-Resolved Single Molecule Localization Microscopy.

Manko H, Burton MG, Mély Y, Godet J

Chemphyschem. 2024 04 2;:e202400101

Targeted Single Particle Tracking with Upconverting Nanoparticles.

Dukhno O, Ghosh S, Greiner V, Bou S, Godet J, Muhr V, Buchner M, Hirsch T, Mély Y, Przybilla F

ACS Appl Mater Interfaces. 2024 02 22;:

The Arabidopsis tDR Ala forms G-quadruplex structures that can be unwound by the DExH1 DEA(D/H)-box RNA helicase.

Chery M, Berrissou C, Humbert N, Hummel G, Mely Y, Salinas-Giegé T, Drouard L

Plant J. 2023 12 19;:

Otto Wolfbeis 1947-2023.

Birch DJS, Levitus M, Mély Y

Methods Appl Fluoresc. 2023 12 13;12(1):

HIV-1 Gag targeting to the plasma membrane reorganizes sphingomyelin-rich and cholesterol-rich lipid domains.

Tomishige N, Bin Nasim M, Murate M, Pollet B, Didier P, Godet J, Richert L, Sako Y, Mély Y, Kobayashi T

Nat Commun. 2023 11 21;14(1):7353

Quantitative live imaging reveals a direct interaction between CD44v6 and MET in membrane domains upon activation with both MET ligands, HGF and internalin B.

Tannoo RM, Richert L, Koschut D, Tomishige N, Treffert SM, Kobayashi T, Mély Y, Orian-Rousseau V

Biochim Biophys Acta Biomembr. 2023 10 2;:184236

The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7.

Zgheib S, Taha N, Zeiger M, Glushonkov O, Lequeu T, Anton H, Didier P, Boutant E, Mély Y, Réal E

J Virol. 2023 09 11;:e0004023

Natural and Synthetic Anticancer Epidrugs Targeting the Epigenetic Integrator UHRF1.

Ashraf W, Ahmad T, Reynoird N, Hamiche A, Mély Y, Bronner C, Mousli M

Molecules. 2023 08 10;28(16):

The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton.

Rivera Alvarez J, Asselin L, Tilly P, Benoit R, Batisse C, Richert L, Batisse J, Morlet B, Levet F, Schwaller N, Mély Y, Ruff M, Reymann AC, Godin JD

Cell Rep. 2023 07 6;42(7):112744

Assembly dynamics and structure of an aegerolysin, ostreolysin A6.

Yilmaz N, Panevska A, Tomishige N, Richert L, Mély Y, Sepčić K, Greimel P, Kobayashi T

J Biol Chem. 2023 06 19;:104940

Cell density-dependent membrane distribution of ganglioside GM3 in melanoma cells.

Murate M, Yokoyama N, Tomishige N, Richert L, Humbert N, Pollet B, Makino A, Kono N, Mauri L, Aoki J, Sako Y, Sonnino S, Komura N, Ando H, Kaneko MK, Kato Y, Inamori KI, Inokuchi JI, Mély Y, Iwabuchi K, Kobayashi T

Cell Mol Life Sci. 2023 05 30;80(6):167

Inhibitors of UHRF1 base flipping activity showing cytotoxicity against cancer cells.

Ciaco S, Mazzoleni V, Javed A, Eiler S, Ruff M, Mousli M, Mori M, Mély Y

Bioorg Chem. 2023 05 22;137:106616

Advancing Spectrally-Resolved Single Molecule Localization Microscopy with Deep Learning.

Manko H, Mély Y, Godet J

Small. 2023 04 24;:e2300728

V-ATPase modulates exocytosis in neuroendocrine cells through the activation of the ARNO-Arf6-PLD pathway and the synthesis of phosphatidic acid.

Wang Q, Wolf A, Ozkan S, Richert L, Mely Y, Chasserot-Golaz S, Ory S, Gasman S, Vitale N

Front Mol Biosci. 2023 04 7;10:1163545

Quantity with quality.

Birch DJS, Levitus M, Mély Y

Methods Appl Fluoresc. 2023 01 3;11(1):

Upstream of N-Ras (Unr/CSDE1) Interacts with NCp7 and Gag, Modulating HIV-1 IRES-Mediated Translation Initiation.

Taha N, Zgheib S, Sharma KK, Humbert N, Boutant E, Didier P, Mély Y, Real E

Viruses. 2022 08 17;14(8):

Thienoguanosine, a unique non-perturbing reporter for investigating rotational dynamics of DNA duplexes and their complexes with proteins.

Grytsyk N, Richert L, Didier P, Dziuba D, Ciaco S, Mazzoleni V, Lequeu T, Mori M, Tor Y, Martinez-Fernandez L, Improta R, Mély Y

Int J Biol Macromol. 2022 07 31;213:210-225

Upconversion in a d-f [RuYb] Supramolecular Assembly.

Knighton RC, Soro LK, Thor W, Strub JM, Cianférani S, Mély Y, Lenertz M, Wong KL, Platas-Iglesias C, Przybilla F, Charbonnière LJ

J Am Chem Soc. 2022 06 30;:

Identification of Allosteric Hotspots regulating the ribosomal RNA-binding by Antibiotic Resistance-Conferring Erm Methyltransferases.

Bhujbalrao R, Gavvala K, Singh RK, Singh J, Boudier C, Chakrabarti S, Patwari GN, Mély Y, Anand R

J Biol Chem. 2022 06 27;:102208

Thienoguanosine brightness in DNA duplexes is governed by the localization of its ππ* excitation in the lowest energy absorption band.

Ciaco S, Gavvala K, Greiner V, Mazzoleni V, Didier P, Ruff M, Martinez-Fernandez L, Improta R, Mely Y

Methods Appl Fluoresc. 2022 Apr 26;:

Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization.

Deffieu MS, Clément CMH, Dorobantu CM, Partiot E, Bare Y, Faklaris O, Rivière B, Ayala-Nunez NV, Baumert TF, Rondé P, Mély Y, Lucansky V, Gaudin R

Hepatology. 2022 Apr 7;:

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop.

Walter RJ, Sonnentag SJ, Munoz-Sagredo L, Merkel M, Richert L, Bunert F, Heneka YM, Loustau T, Hodder M, Ridgway RA, Sansom OJ, Mely Y, Rothbauer U, Schmitt M, Orian-Rousseau V

Cell Death Dis. 2022 Feb 21;13(2):168

moves higher and faster.

Birch DJS, Levitus M, Mély Y

Methods Appl Fluoresc. 2021 12 14;10(1):

Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of .

Ashraf W, Ahmad T, Almalki NAR, Krifa M, Zaayter L, Pizzi A, Muller CD, Hamiche A, Mély Y, Bronner C, Mousli M

Food Funct. 2021 Dec 13;:

TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex.

Ahmad T, Ashraf W, Ibrahim A, Zaayter L, Muller CD, Hamiche A, Mély Y, Bronner C, Mousli M

Int J Oncol. 2021 Nov;59(5):

Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets.

Grytsyk N, Cianfarani D, Crégut O, Richert L, Boudier C, Humbert N, Didier P, Mély Y, Léonard J

Nucleic Acids Res. 2021 Aug 27;:

Molecular organization in hydroperoxidized POPC bilayers.

Junqueira H, Schroder AP, Thalmann F, Klymchenko A, Mély Y, Baptista MS, Marques CM

Biochim Biophys Acta Biomembr. 2021 May 27;:183659

Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues.

Dziuba D, Didier P, Ciaco S, Barth A, Seidel CAM, Mély Y

Chem Soc Rev. 2021 May 6;:

Intermolecular dark resonance energy transfer (DRET): upgrading fluorogenic DNA sensing.

Barnoin G, Shaya J, Richert L, Le HN, Vincent S, Guérineau V, Mély Y, Michel BY, Burger A

Nucleic Acids Res. 2021 Apr 19;:

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA.

Jiang K, Humbert N, K K S, Rouzina I, Mely Y, Westerlund F

Nucleic Acids Res. 2021 Apr 19;:

Live-cell imaging of the nucleolus and mapping mitochondrial viscosity with a dual function fluorescent probe.

Mukherjee T, Soppina V, Ludovic R, Mély Y, Klymchenko AS, Collot M, Kanvah S

Org Biomol Chem. 2021 Feb 8;:

Imaging Viral Infection by Fluorescence Microscopy: Focus on HIV-1 Early Stage.

Mukherjee S, Boutant E, Réal E, Mély Y, Anton H

Viruses. 2021 Jan 30;13(2):

Suborganellar Localization of Mitochondrial Proteins and Transcripts in Human Cells.

Smirnova A, Richert L, Smirnov A, Mély Y, Tarassov I

Methods Mol Biol. 2021 ;2277:157-173

The use of pore-forming toxins to image lipids and lipid domains.

Tomishige N, Murate M, Didier P, Richert L, Mély Y, Kobayashi T

Methods Enzymol. 2021 ;649:503-542

MAF and fluorescence play their part.

Birch DJS, Levitus M, Mely Y

Methods Appl Fluoresc. 2020 Nov 25;:

Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein.

Mori M, Ciaco S, Mély Y, Karioti A

Molecules. 2020 Nov 20;25(22):

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR.

Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N

Nucleic Acids Res.. 2020 Sep 25;48(17):9969-9985

What makes thienoguanosine an outstanding fluorescent DNA probe?

Kuchlyan J, Martinez-Fernandez L, Mori M, Gavvala K, Ciaco S, Boudier C, Richert L, Didier P, Tor Y, Improta R, Mély Y

J. Am. Chem. Soc.. 2020 Sep 11;:

FLIM-FRET Measurements of Protein-Protein Interactions in Live Bacteria.

Manko H, Normant V, Perraud Q, Steffan T, Gasser V, Boutant E, Réal É, Schalk IJ, Mély Y, Godet J

J Vis Exp. 2020 Aug 25;(162):

The nucleic acid chaperone activity of the HIV-1 Gag polyprotein is boosted by its cellular partner RPL7: a kinetic study.

Karnib H, Nadeem MF, Humbert N, Sharma KK, Grytsyk N, Tisné C, Boutant E, Lequeu T, Réal E, Boudier C, de Rocquigny H, Mély Y

Nucleic Acids Res.. 2020 Aug 14;:

How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain.

Klingler J, Anton H, Réal E, Zeiger M, Moog C, Mély Y, Boutant E

Viruses. 2020 Aug 13;12(8):

Differential recognition of lipid domains by two Gb3-binding lectins.

Schubert T, Sych T, Madl J, Xu M, Omidvar R, Patalag LJ, Ries A, Kettelhoit K, Brandel A, Mely Y, Steinem C, Werz DB, Thuenauer R, Römer W

Sci Rep. 2020 Jun 16;10(1):9752

Zinc Fingers in HIV-1 Gag Precursor Are Not Equivalent for gRNA Recruitment at the Plasma Membrane.

Boutant E, Bonzi J, Anton H, Nasim MB, Cathagne R, Réal E, Dujardin D, Carl P, Didier P, Paillart JC, Marquet R, Mély Y, de Rocquigny H, Bernacchi S

Biophys. J.. 2020 Jun 12;:

5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.

Malancona S, Mori M, Fezzardi P, Santoriello M, Basta A, Nibbio M, Kovalenko L, Speziale R, Battista MR, Cellucci A, Gennari N, Monteagudo E, Di Marco A, Giannini A, Sharma R, Pires M, Real E, Zazzi M, Dasso Lang MC, De Forni D, Saladini F, Mely Y, Summa V, Harper S, Botta M

ACS Med Chem Lett. 2020 May 14;11(5):766-772

A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds.

Ciaco S, Humbert N, Real E, Boudier C, Francesconi O, Roelens S, Nativi C, Seguin-Devaux C, Mori M, Mély Y

ACS Med Chem Lett. 2020 May 14;11(5):698-705

Excited-State Proton Transfer in Oxyluciferin and its Analogues.

Gosset P, Taupier G, Cregut O, Brazard J, Mély Y, Dorkenoo KD, Léonard J, Didier P

J Phys Chem Lett. 2020 Apr 20;:

Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine.

Didier P, Kuchlyan J, Martinez-Fernandez L, Gosset P, Léonard J, Tor Y, Improta R, Mély Y

Phys Chem Chem Phys. 2020 Mar 25;:

Cholesterol asymmetry at the tip of filopodia during cell adhesion.

Kishimoto T, Tomishige N, Murate M, Ishitsuka R, Schaller H, Mély Y, Ueda K, Kobayashi T

FASEB J.. 2020 Mar 12;:

Electronic transitions and ESIPT kinetics of the thienyl-3-hydroxychromone nucleobase surrogate in DNA duplexes: a DFT/MD-TDDFT study.

Sougnabé A, Lissouck D, Fontaine-Vive F, Nsangou M, Mély Y, Burger A, Kenfack CA

RSC Adv. 2020 Feb 18;10(13):7349-7359

(Thia)calixarenephosphonic acids as potent inhibitors of the nucleic acid chaperone activity of the HIV-1 nucleocapsid protein with a new binding mode and multi-target antiviral activity.

Humbert N, Kovalenko L, Saladini F, Giannini A, Pires M, Botzanowski T, Cherenok S, Boudier C, Sharma KK, Real E, Zaporozhets OA, Cianférani S, Seguin-Devaux C, Poggialini F, Botta M, Zazzi M, Kalchenko VI, Mori M, Mély Y

ACS Infect Dis. 2020 Feb 11;:

Characterization of endogenous Claudin1 expression, motility and susceptibility to Hepatitis C Virus in CRISPR knock-in cells.

Clément CMH, Deffieu MS, Dorobantu CM, Baumert TF, Ayala-Nunez NV, Mély Y, Ronde P, Gaudin R

Biol. Cell. 2020 Feb 7;:

FRET-FLIM and single molecule tracking reveal the supra-molecular organization of the pyoverdine bio-synthetic enzymes in .

Gasser V, Malrieu M, Forster A, Mély Y, Schalk IJ, Godet J

Q. Rev. Biophys.. 2020 Jan 9;53:e1

Exploring protein-protein interactions with large differences in protein expression levels using FLIM-FRET.

Godet J, Mely Y

Methods Appl Fluoresc. 2019 Dec 2;:

MAF leads fluorescence into the new decade.

Birch DJS, Mely Y, Levitus M

Methods Appl Fluoresc. 2019 Nov 25;:

A molecular tool targeting the base flipping activity of human UHRF1.

Zaayter L, Mori M, Ahmad T, Ashraf W, Boudier C, Kilin V, Gavvala K, Richert L, Eiler S, Ruff M, Botta M, Bronner C, Mousli M, Mely Y

Chemistry. 2019 Jul 19;:

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein.

Mori M, Dasso Lang MC, Saladini F, Palombi N, Kovalenko L, De Forni D, Poddesu B, Friggeri L, Giannini A, Malancona S, Summa V, Zazzi M, Mely Y, Botta M

ACS Med Chem Lett. 2019 Apr 11;10(4):463-468

Formation of tubules and helical ribbons by ceramide phosphoethanolamine-containing membranes.

Inaba T, Murate M, Tomishige N, Lee YF, Hullin-Matsuda F, Pollet B, Humbert N, Mély Y, Sako Y, Greimel P, Kobayashi T

Sci Rep. 2019 Apr 9;9(1):5812

Excited state dynamics of thienoguanosine, an isomorphic highly fluorescent analogue of guanosine.

Martinez-Fernandez L, Gavvala K, Sharma R, Pascal D, Richert L, Segarra Martì J, Mori M, Mely Y, Improta R

Chemistry. 2019 Mar 18;:

MemBright: A Family of Fluorescent Membrane Probes for Advanced Cellular Imaging and Neuroscience.

Collot M, Ashokkumar P, Anton H, Boutant E, Faklaris O, Galli T, Mély Y, Danglot L, Klymchenko AS

Cell Chem Biol. 2019 Feb 6;:

Probing Polarity and Heterogeneity of Lipid Droplets in Live Cells Using a Push-Pull Fluorophore.

Collot M, Bou S, Fam TK, Richert L, Mély Y, Danglot L, Klymchenko AS

Anal. Chem.. 2019 Feb 5;91(3):1928-1935

Molecular Upconversion in Water in Heteropolynuclear Supramolecular Tb/Yb Assemblies.

Nonat A, Bahamyirou S, Lecointre A, Przybilla F, Mély Y, Platas-Iglesias C, Camerel F, Jeannin O, Charbonnière LJ

J. Am. Chem. Soc.. 2019 Jan 30;141(4):1568-1576

Quantitative monitoring of the cytoplasmic release of NCp7 proteins from individual HIV-1 viral cores during the early steps of infection.

Zgheib S, Lysova I, Réal E, Dukhno O, Vauchelles R, Pires M, Anton H, Mély Y

Sci Rep. 2019 Jan 30;9(1):945

Towards the formulation of stable micro and nano double emulsions through silica coating of internal water droplets.

Akram S, Wang X, Vandamme TF, Collot M, Rehman AU, Messaddeq N, Mély Y, Anton N

Langmuir. 2019 Jan 10;:

Fluorescence Spans the Globe.

Birch DJS, Mely Y, Wolfbeis OS

Methods Appl Fluoresc. 2019 Jan 7;:

Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels.

Jiang K, Humbert N, Kk S, Lequeu T, Lin YL, Mely Y, Westerlund F

Q. Rev. Biophys.. 2019 Jan;52:e2

GUV-AP: multifunctional FIJI-based tool for quantitative image analysis of Giant Unilamellar Vesicles.

Sych T, Schubert T, Vauchelles R, Madl J, Omidvar R, Thuenauer R, Richert L, Mély Y, Römer W

Bioinformatics. 2018 Nov 26;:

Development of Doxorubicin hydrochloride loaded pH-sensitive liposomes: Investigation on the impact of chemical nature of lipids and liposome composition on pH-sensitivity.

Ur Rehman A, Omran Z, Anton H, Mély Y, Akram S, Vandamme TF, Anton N

Eur J Pharm Biopharm. 2018 Nov 8;:

Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy.

Bouchaala R, Richert L, Anton N, Vandamme TF, Djabi S, Mély Y, Klymchenko AS

ACS Omega. 2018 Oct 31;3(10):14333-14340

Time-dependent luminescence loss for individual upconversion nanoparticles upon dilution in aqueous solution.

Dukhno O, Przybilla F, Muhr V, Buchner M, Hirsch T, Mély Y

Nanoscale. 2018 Aug 14;:

A key role for the periplasmic PfeE esterase in iron acquisition via the siderophore Enterobactin in Pseudomonas aeruginosa.

Perraud Q, Moynie L, Gasser V, Munier M, Godet J, Hoegy F, Mély Y, Mislin GLA, Naismith JH, Schalk IJ

ACS Chem. Biol.. 2018 Aug 7;:

Rationally Designed Peptides as Efficient Inhibitors of Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein.

Shvadchak V, Zgheib S, Basta B, Humbert N, Langedijk J, Morris MC, Ciaco S, Maskri O, Darlix JL, Mauffret O, Fossé P, Réal E, Mély Y

Biochemistry. 2018 Jul 18;:

Environmentally-Sensitive Fluorescent Nucleoside Analogues for Surveying Dynamic Interconversions of Nucleic Acid Structures.

Sholokh M, Sharma R, Grytsyk N, Zaghzi L, Postupalenko V, Dziuba D, Barthes N, Michel B, Boudier C, Zaporozhets O, Tor Y, Burger A, Mely Y

Chemistry. 2018 Jul 10;:

ReAsH/tetracystein-based Correlative Light-Electron Microscopy for HIV-1 imaging during the early stages of infection.

Lysova I, Spiegelhalter C, Réal E, Zgheib S, Anton H, Mely Y

Methods Appl Fluoresc. 2018 Jun 25;:

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells.

Ibrahim A, Alhosin M, Papin C, Ouararhni K, Omran Z, Zamzami MA, Al-Malki AL, Choudhry H, Mély Y, Hamiche A, Mousli M, Bronner C

Oncotarget. 2018 Jun 19;9(47):28599-28611

Optimized protocol for combined PALM-dSTORM imaging.

Glushonkov O, Réal E, Boutant E, Mély Y, Didier P

Sci Rep. 2018 Jun 8;8(1):8749

Lipid self-assembly and lectin-induced reorganization of the plasma membrane.

Sych T, Mély Y, Römer W

Philos. Trans. R. Soc. Lond., B, Biol. Sci.. 2018 May 26;373(1747):

The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101.

El Meshri SE, Boutant E, Mouhand A, Thomas A, Larue V, Richert L, Vivet-Boudou V, Mély Y, Tisné C, Muriaux D, de Rocquigny H

Biochim. Biophys. Acta. 2018 Mar 20;1862(6):1421-1431

Ultrafast photophysics of the environment-sensitive 4'-methoxy-3-hydroxyflavone fluorescent dye.

Skilitsi AI, Agathangelou D, Shulov I, Conyard J, Haacke S, Mély Y, Klymchenko A, Léonard J

Phys Chem Chem Phys. 2018 Mar 14;20(11):7885-7895

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein.

Gamba E, Mori M, Kovalenko L, Giannini A, Sosic A, Saladini F, Fabris D, Mély Y, Gatto B, Botta M

Eur J Med Chem. 2018 Feb 10;145:154-164

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

Mori M, Kovalenko L, Malancona S, Saladini F, De Forni D, Pires M, Humbert N, Real E, Botzanowski T, Cianférani S, Giannini A, Dasso Lang MC, Cugia G, Poddesu B, Lori F, Zazzi M, Harper S, Summa V, Mely Y, Botta M

ACS Chem. Biol.. 2018 01 19;13(1):253-266

Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.

Ashraf W, Bronner C, Zaayter L, Ahmad T, Richert L, Alhosin M, Ibrahim A, Hamiche A, Mely Y, Mousli M

J. Exp. Clin. Cancer Res.. 2017 12 21;36(1):188

Structural and Dynamical Impact of a Universal Fluorescent Nucleoside Analogue Inserted Into a DNA Duplex.

Zargarian L, Ben Imeddourene A, Gavvala K, Barthes NPF, Michel BY, Kenfack CA, Morellet N, René B, Fossé P, Burger A, Mély Y, Mauffret O

J Phys Chem B. 2017 12 21;121(50):11249-11261

Turn-on Fluorene Push-Pull Probes with High Brightness and Photostability for Visualizing Lipid Order in Biomembranes.

Shaya J, Collot M, Bénailly F, Mahmoud N, Mély Y, Michel BY, Klymchenko AS, Burger A

ACS Chem. Biol.. 2017 12 15;12(12):3022-3030

Giant light-harvesting nanoantenna for single-molecule detection in ambient light.

Trofymchuk K, Reisch A, Didier P, Fras F, Gilliot P, Mely Y, Klymchenko AS

Nat Photonics. 2017 Oct;11(10):657-663

Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study.

Pyrshev KA, Yesylevskyy SO, Mely Y, Demchenko AP, Klymchenko AS

Biochim. Biophys. Acta. 2017 Aug;:

Quantitative assessment of energy transfer in upconverting nanoparticles grafted with organic dyes.

Dukhno O, Przybilla F, Collot M, Klymchenko A, Pivovarenko V, Buchner M, Muhr V, Hirsch T, Mély Y

Nanoscale. 2017 Aug;:

The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.

Ashraf W, Ibrahim A, Alhosin M, Zaayter L, Ouararhni K, Papin C, Ahmad T, Hamiche A, Mély Y, Bronner C, Mousli M

Oncotarget. 2017 Aug;8(31):51946-51962

A toolbox of chromones and quinolones for measuring a wide range of ATP concentrations.

Pivovarenko VG, Bugera O, Humbert N, Klymchenko AS, Mély Y

Chemistry. 2017 Jul;:

Coactivators and general transcription factors have two distinct dynamic populations dependent on transcription.

Vosnakis N, Koch M, Scheer E, Kessler P, Mély Y, Didier P, Tora L

EMBO J.. 2017 Jul;:

Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo.

Bouchaala R, Anton N, Anton H, Vandamme T, Vermot J, Smail D, Mély Y, Klymchenko AS

Colloids Surf B Biointerfaces. 2017 May;156:414-421

The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.

Ashraf W, Ibrahim A, Alhosin M, Zaayter L, Ouararhni K, Papin C, Ahmad T, Hamiche A, Mély Y, Bronner C, Mousli M

Oncotarget. 2017 Apr;:

Dynamics of Methylated Cytosine Flipping by UHRF1.

Kilin V, Gavvala K, Barthes NP, Michel BY, Shin D, Boudier C, Mauffret O, Yashchuk V, Mousli M, Ruff M, Granger F, Eiler S, Bronner C, Tor Y, Burger A, Mély Y

J. Am. Chem. Soc.. 2017 Feb;139(6):2520-2528

Oxyluciferin Derivatives: A Toolbox of Environment-Sensitive Fluorescence Probes for Molecular and Cellular Applications.

Ghose A, Maltsev OV, Humbert N, Hintermann L, Arntz Y, Naumov P, Mély Y, Didier P

J Phys Chem B. 2017 Feb;121(7):1566-1575

Building a quality home for fluorescence.

Birch D, Mely Y, Wolfbeis O

Methods Appl Fluoresc. 2016 Nov;4(4):040401

Design and Development of a Two-Color Emissive FRET Pair Based on a Photostable Fluorescent Deoxyuridine Donor Presenting a Mega-Stokes Shift.

Barthes NP, Gavvala K, Bonhomme D, Dabert-Gay AS, Debayle D, Mély Y, Michel BY, Burger A

J. Org. Chem.. 2016 Nov;81(22):10733-10741

Tuning luminescent properties of CdSe nanoclusters by phosphine surface passivation.

Lysova I, Anton H, Dmitruk I, Mely Y

Methods Appl Fluoresc. 2016 Nov;4(4):044009

Fluorescence correlation spectroscopy as a sensitive and useful tool for revealing potential overlaps between the epitopes of monoclonal antibodies on viral particles.

Richert L, Humbert N, Larquet E, Girerd-Chambaz Y, Manin C, Ronzon F, Mély Y

MAbs. 2016 Oct;8(7):1235-1244

The multiple roles of the nucleocapsid in retroviral RNA conversion into proviral DNA by reverse transcriptase.

Darlix JL, de Rocquigny H, Mély Y

Biochem. Soc. Trans.. 2016 Oct;44(5):1427-1440

Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling.

Mekdad HE, Boutant E, Karnib H, Biedma ME, Sharma KK, Malytska I, Laumond G, Roy M, Réal E, Paillart JC, Moog C, Darlix JL, Mély Y, de Rocquigny H

Retrovirology. 2016 Aug;13(1):54

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors.

Elgaher WA, Sharma KK, Haupenthal J, Saladini F, Pires M, Real E, Mély Y, Hartmann RW

J. Med. Chem.. 2016 Aug;59(15):7212-22

Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice.

Bouchaala R, Mercier L, Andreiuk B, Mély Y, Vandamme T, Anton N, Goetz JG, Klymchenko AS

J Control Release. 2016 Aug;236:57-67

Environment-sensitive quinolone demonstrating long-lived fluorescence and unusually slow excited-state intramolecular proton transfer kinetics.

Zamotaiev OM, Shvadchak V, Sych TP, Melnychuk NA, Yushchenko D, Mely Y, Pivovarenko VG

Methods Appl Fluoresc. 2016 Jul;4(3):034004

Live cell imaging shows hepatocyte growth factor-induced Met dimerization.

Koschut D, Richert L, Pace G, Niemann HH, Mély Y, Orian-Rousseau V

Biochim. Biophys. Acta. 2016 Jul;1863(7 Pt A):1552-8

Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.

Sholokh M, Improta R, Mori M, Sharma R, Kenfack C, Shin D, Voltz K, Stote RH, Zaporozhets OA, Botta M, Tor Y, Mély Y

Angew. Chem. Int. Ed. Engl.. 2016 Jul;55(28):7974-8

Non-coordinating anions assemble cyanine amphiphiles into ultra-small fluorescent nanoparticles.

Shulov I, Arntz Y, Mély Y, Pivovarenko VG, Klymchenko AS

Chem. Commun. (Camb.). 2016 Jun;52(51):7962-5

FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein.

Sharma KK, Przybilla F, Restle T, Godet J, Mély Y

Nucleic Acids Res.. 2016 May;44(8):e74

Insights into the mechanisms of RNA secondary structure destabilization by the HIV-1 nucleocapsid protein.

Belfetmi A, Zargarian L, Tisné C, Sleiman D, Morellet N, Lescop E, Maskri O, René B, Mély Y, Fossé P, Mauffret O

RNA. 2016 Apr;22(4):506-17

Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy.

Voltz K, Léonard J, Touceda PT, Conyard J, Chaker Z, Dejaegere A, Godet J, Mély Y, Haacke S, Stote RH

Nucleic Acids Res.. 2016 Apr;44(7):3408-19

Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells.

Desplancq D, Freund G, Conic S, Sibler AP, Didier P, Stoessel A, Oulad-Abdelghani M, Vigneron M, Wagner J, Mély Y, Chatton B, Tora L, Weiss E

Exp. Cell Res.. 2016 Mar;342(2):145-58

Structural Insights into the HIV-1 Minus-strand Strong-stop DNA.

Chen Y, Maskri O, Chaminade F, René B, Benkaroun J, Godet J, Mély Y, Mauffret O, Fossé P

J. Biol. Chem.. 2016 Feb;291(7):3468-82

Bright and photostable push-pull pyrene dye visualizes lipid order variation between plasma and intracellular membranes.

Niko Y, Didier P, Mely Y, Konishi G, Klymchenko AS

Sci Rep. 2016 Jan;6:18870

A journal in ascendancy.

Birch D, Mely Y, Wolfbeis O

Methods Appl Fluoresc. 2015 Nov 26;3(4):040203

Bright fluorogenic squaraines with tuned cell entry for selective imaging of plasma membrane vs. endoplasmic reticulum.

Collot M, Kreder R, Tatarets AL, Patsenker LD, Mely Y, Klymchenko AS

Chem Commun (Camb). 2015 Nov 19;51(96):17136-9

Fluorinated counterion-enhanced emission of rhodamine aggregates: ultrabright nanoparticles for bioimaging and light-harvesting.

Shulov I, Oncul S, Reisch A, Arntz Y, Collot M, Mely Y, Klymchenko AS

Nanoscale. 2015 Oct 29;7(43):18198-210

Inter-nanocarrier and nanocarrier-to-cell transfer assays demonstrate the risk of an immediate unloading of dye from labeled lipid nanocapsules.

Simonsson C, Bastiat G, Pitorre M, Klymchenko AS, Bejaud J, Mely Y, Benoit JP

Eur J Pharm Biopharm. 2015 Oct 30. pii: S0939-6411(15)00426-9

Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.

Greiner VJ, Kovalenko L, Humbert N, Richert L, Birck C, Ruff M, Zaporozhets OA, Dhe-Paganon S, Bronner C, Mely Y

Biochemistry. 2015 Sep 23.

Reverse Transcriptase in Action: FRET-Based Assay for Monitoring Flipping and Polymerase Activity in Real Time.

Sharma KK, Przybilla F, Restle T, Boudier C, Godet J, Mély Y

Anal. Chem.. 2015 Aug;87(15):7690-7

Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties.

Neuberg P, Perino A, Morin-Picardat E, Anton N, Darwich Z, Weltin D, Mely Y, Klymchenko AS, Remy JS, Wagner A

Chem. Commun. (Camb.). 2015 Jul;51(58):11595-8

Protein Delivery System Containing a Nickel-Immobilized Polymer for Multimerization of Affinity-Purified His-Tagged Proteins Enhances Cytosolic Transfer.

Postupalenko V, Desplancq D, Orlov I, Arntz Y, Spehner D, Mely Y, Klaholz BP, Schultz P, Weiss E, Zuber G

Angew Chem Int Ed Engl. 2015 Jul 31

Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.

Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mély Y, Heilemann M, Niemann HH, Orian-Rousseau V

Biosci. Rep.. 2015 Jun;35(4):

Exploiting Fast Exciton Diffusion in Dye-Doped Polymer Nanoparticles to Engineer Efficient Photoswitching.

Trofymchuk K, Prodi L, Reisch A, Mely Y, Altenhoner K, Mattay J, Klymchenko AS

J Phys Chem Lett. 2015 Jun 18;6(12):2259-64

Solvatochromic Nile Red probes with FRET quencher reveal lipid order heterogeneity in living and apoptotic cells.

Kreder R, Pyrshev KA, Darwich Z, Kucherak OA, Mély Y, Klymchenko AS

ACS Chem. Biol.. 2015 Jun;10(6):1435-42

Internalization mechanism of neuropeptide Y bound to its Y receptor investigated by high resolution microscopy.

Kempf N, Didier P, Postupalenko V, Bucher B, Mély Y

Methods Appl Fluoresc. 2015 May 6;3(2):025004

Fluorescence lifetime imaging of membrane lipid order with a ratiometric fluorescent probe.

Kilin V, Glushonkov O, Herdly L, Klymchenko A, Richert L, Mely Y

Biophys J. 2015 May 19;108(10):2521-31

Charge-Controlled Nanoprecipitation as a Modular Approach to Ultrasmall Polymer Nanocarriers: Making Bright and Stable Nanoparticles.

Reisch A, Runser A, Arntz Y, Mely Y, Klymchenko AS

ACS Nano. 2015 Apr 20.

Conquering 2-aminopurine's deficiencies: highly emissive isomorphic guanosine surrogate faithfully monitors guanosine conformation and dynamics in DNA.

Sholokh M, Sharma R, Shin D, Das R, Zaporozhets OA, Tor Y, Mély Y

J. Am. Chem. Soc.. 2015 Mar;137(9):3185-8

Role of the nucleocapsid domain in HIV-1 Gag oligomerization and trafficking to the plasma membrane: a fluorescence lifetime imaging microscopy investigation.

El Meshri SE, Dujardin D, Godet J, Richert L, Boudier C, Darlix JL, Didier P, Mely Y, de Rocquigny H

J Mol Biol. 2015 Mar 27;427(6 Pt B):1480-94

Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging.

Karpenko IA, Klymchenko AS, Gioria S, Kreder R, Shulov I, Villa P, Mely Y, Hibert M, Bonnet D

Chem Commun (Camb). 2015 Feb 18;51(14):2960-3

The HIV-1 nucleocapsid protein recruits negatively charged lipids to ensure its optimal binding to lipid membranes.

Kempf N, Postupalenko V, Bora S, Didier P, Arntz Y, de Rocquigny H, Mely Y

J Virol. 2015 Feb;89(3):1756-67

CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4A in glioblastoma cells.

Boukhari A, Alhosin M, Bronner C, Sagini K, Truchot C, Sick E, Schini-Kerth VB, Andre P, Mely Y, Mousli M, Gies JP

Anticancer Res. 2015 Jan;35(1):149-57.

Introduction to fluorescence probing of biological membranes.

Demchenko AP, Duportail G, Oncul S, Klymchenko AS, Mely Y

Methods Mol Biol. 2015;1232:19-43

Investigating the cellular distribution and interactions of HIV-1 nucleocapsid protein by quantitative fluorescence microscopy.

Anton H, Taha N, Boutant E, Richert L, Khatter H, Klaholz B, Ronde P, Real E, de Rocquigny H, Mely Y

PLoS One. 2015 Feb 27;10(2):e0116921

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

Mori M, Kovalenko L, Lyonnais S, Antaki D, Torbett BE, Botta M, Mirambeau G, Mely Y

Curr Top Microbiol Immunol. 2015;389:53-92

Creating a high impact journal for research in fluorescence.

Birch D, Mely Y, Wolfbeis O

Methods Appl Fluoresc. 2014 Dec 31;2(4):040201

Disassembly-driven fluorescence turn-on of polymerized micelles by reductive stimuli in living cells.

Niko Y, Arntz Y, Mely Y, Konishi G, Klymchenko AS

Chemistry. 2014 Dec;20(50):16473-7

Fluorogenic Squaraine Dimers with Polarity-Sensitive Folding As Bright Far-Red Probes for Background-Free Bioimaging.

Karpenko IA, Collot M, Richert L, Valencia C, Villa P, Mely Y, Hibert M, Bonnet D, Klymchenko AS

J Am Chem Soc. 2014 Dec 29.

Emission Properties of Oxyluciferin and Its Derivatives in Water: Revealing the Nature of the Emissive Species in Firefly Bioluminescence.

Ghose A, Rebarz M, Maltsev OV, Hintermann L, Ruckebusch C, Fron E, Hofkens J, Mely Y, Naumov P, Sliwa M, Didier P

J Phys Chem B. 2014 Nov 18.

Lipid emulsions differentially affect LPS-induced acute monocytes inflammation: in vitro effects on membrane remodeling and cell viability.

Boisrame-Helms J, Delabranche X, Klymchenko A, Drai J, Blond E, Zobairi F, Mely Y, Hasselmann M, Toti F, Meziani F

Lipids. 2014 Nov;49(11):1091-9

Retrospective on the all-in-one retroviral nucleocapsid protein.

Darlix JL, de Rocquigny H, Mauffret O, Mely Y

Virus Res. 2014 Nov 26;193:2-15

Role of the nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy.

de Rocquigny H, El Meshri SE, Richert L, Didier P, Darlix JL, Mely Y

Virus Res. 2014 Nov 26;193:78-88

Biodistribution of X-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core.

Attia MF, Anton N, Chiper M, Akasov R, Anton H, Messaddeq N, Fournel S, Klymchenko AS, Mely Y, Vandamme TF

ACS Nano. 2014 Oct 28;8(10):10537-50

Fluorescent Amino Acid Undergoing Excited State Intramolecular Proton Transfer for Site-Specific Probing and Imaging of Peptide Interactions.

Sholokh M, Zamotaiev OM, Das R, Postupalenko VY, Richert L, Dujardin D, Zaporozhets OA, Pivovarenko VG, Klymchenko AS, Mely Y

J Phys Chem B. 2014 Oct 22.

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

Mori M, Nucci A, Lang MC, Humbert N, Boudier C, Debaene F, Sanglier-Cianferani S, Catala M, Schult-Dietrich P, Dietrich U, Tisne C, Mely Y, Botta M

ACS Chem Biol. 2014 Sep 19;9(9):1950-5

Monitoring penetratin interactions with lipid membranes and cell internalization using a new hydration-sensitive fluorescent probe.

Zamotaiev OM, Postupalenko VY, Shvadchak VV, Pivovarenko VG, Klymchenko AS, Mely Y

Org Biomol Chem. 2014 Sep 28;12(36):7036-44

Counterion-enhanced cyanine dye loading into lipid nano-droplets for single-particle tracking in zebrafish.

Kilin VN, Anton H, Anton N, Steed E, Vermot J, Vandamme TF, Mely Y, Klymchenko AS

Biomaterials. 2014 Jun;35(18):4950-7

Comparison of the Oilseed rape mosaic virus and Tobacco mosaic virus movement proteins (MP) reveals common and dissimilar MP functions for tobamovirus spread.

Niehl A, Pasquier A, Ferriol I, Mély Y, Heinlein M

Virology. 2014 May;456-457:43-54

Out-of-equilibrium biomolecular interactions monitored by picosecond fluorescence in microfluidic droplets.

Maillot S, Carvalho A, Vola JP, Boudier C, Mely Y, Haacke S, Leonard J

Lab Chip. 2014 May 21;14(10):1767-74

Poly-epsilon-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography.

Jakhmola A, Anton N, Anton H, Messaddeq N, Hallouard F, Klymchenko A, Mely Y, Vandamme TF

Biomaterials. 2014 Mar;35(9):2981-6

Characterization of the structural modifications accompanying the loss of HBsAg particle immunogenicity.

Greiner VJ, Manin C, Larquet E, Ikhelef N, Greco F, Naville S, Milhiet PE, Ronzon F, Klymchenko A, Mely Y

Vaccine. 2014 Feb 19;32(9):1049-54

Rational design of a solvatochromic fluorescent uracil analogue with a dual-band ratiometric response based on 3-hydroxychromone.

Dziuba D, Karpenko IA, Barthes NP, Michel BY, Klymchenko AS, Benhida R, Demchenko AP, Mely Y, Burger A

Chemistry. 2014 Feb 10;20(7):1998-2009

Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells.

Karpenko IA, Kreder R, Valencia C, Villa P, Mendre C, Mouillac B, Mely Y, Hibert M, Bonnet D, Klymchenko AS

Chembiochem. 2014 Feb 10;15(3):359-63

Collective fluorescence switching of counterion-assembled dyes in polymer nanoparticles.

Reisch A, Didier P, Richert L, Oncul S, Arntz Y, Mely Y, Klymchenko AS

Nat Commun. 2014 Jun 9;5:4089

Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription.

Boudier C, Humbert N, Chaminade F, Chen Y, de Rocquigny H, Godet J, Mauffret O, Fosse P, Mely Y

Nucleic Acids Res. 2014 Jan;42(2):1065-78

Dynamics of linker residues modulate the nucleic acid binding properties of the HIV-1 nucleocapsid protein zinc fingers.

Zargarian L, Tisne C, Barraud P, Xu X, Morellet N, Rene B, Mely Y, Fosse P, Mauffret O

PLoS One. 2014 Jul 16;9(7):e102150

Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe.

Darwich Z, Klymchenko AS, Dujardin D, Mely Y

Rsc Adv. 2014;4(17):8481-8.

Monitoring membrane properties and apoptosis using membrane probes of the 3-hydroxyflavone family.

Darwich Z, Klymchenko AS, Mely Y

Methods Mol Biol. 2014;1076:419-30

Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors.

Ferrand A, Eap S, Richert L, Lemoine S, Kalaskar D, Demoustier-Champagne S, Atmani H, Mely Y, Fioretti F, Schlatter G, Kuhn L, Ladam G, Benkirane-Jessel N

Macromol Biosci. 2014 Jan;14(1):45-55

Tuning excited-state proton transfer dynamics of a 3-hydroxychromone dye in supramolecular complexes via host-guest steric compatibility.

Das R, Duportail G, Ghose A, Richert L, Klymchenko A, Chakraborty S, Yesylevskyy S, Mely Y

Phys Chem Chem Phys. 2014 Jan 14;16(2):776-84

Dissecting the oligonucleotide binding properties of a disordered chaperone protein using surface plasmon resonance.

Baltzinger M, Sharma KK, Mely Y, Altschuh D

Nucleic Acids Res. 2013 Dec;41(22):10414-25

Thermodynamically stable dispersions of quantum dots in a nematic liquid crystal.

Prodanov MF, Pogorelova NV, Kryshtal AP, Klymchenko AS, Mely Y, Semynozhenko VP, Krivoshey AI, Reznikov YA, Yarmolenko SN, Goodby JW, Vashchenko VV

Langmuir. 2013 Jul 30;29(30):9301-9

APOBEC3G impairs the multimerization of the HIV-1 Vif protein in living cells.

Batisse J, Guerrero SX, Bernacchi S, Richert L, Godet J, Goldschmidt V, Mely Y, Marquet R, de Rocquigny H, Paillart JC

J Virol. 2013 Jun;87(11):6492-506

Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer.

Godet J, Kenfack C, Przybilla F, Richert L, Duportail G, Mely Y

Nucleic Acids Res. 2013 May;41(9):5036-48

The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells.

Rinaldi AS, Freund G, Desplancq D, Sibler AP, Baltzinger M, Rochel N, Mely Y, Didier P, Weiss E

Exp Cell Res. 2013 Apr 1;319(6):838-49

Fluorescent environment-sensitive dyes as reporters of biomolecular interactions.

Klymchenko AS, Mely Y

Prog Mol Biol Transl Sci. 2013;113:35-58

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.

Krifa M, Alhosin M, Muller CD, Gies JP, Chekir-Ghedira L, Ghedira K, Mely Y, Bronner C, Mousli M

J Exp Clin Cancer Res. 2013 May 20;32:30

Control of Tobacco mosaic virus movement protein fate by CELL-DIVISION-CYCLE protein48.

Niehl A, Amari K, Gereige D, Brandner K, Mély Y, Heinlein M

Plant Physiol.. 2012 Dec;160(4):2093-108

Detection of apoptosis through the lipid order of the outer plasma membrane leaflet.

Darwich Z, Klymchenko AS, Kucherak OA, Richert L, Mely Y

Biochim Biophys Acta. 2012 Dec;1818(12):3048-54

Two-color fluorescent l-amino acid mimic of tryptophan for probing peptide-nucleic acid complexes.

Strizhak AV, Postupalenko VY, Shvadchak VV, Morellet N, Guittet E, Pivovarenko VG, Klymchenko AS, Mely Y

Bioconjug Chem. 2012 Dec 19;23(12):2434-43

Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.

Godet J, Boudier C, Humbert N, Ivanyi-Nagy R, Darlix JL, Mely Y

Virus Res. 2012 Nov;169(2):349-60

Protein-protein and protein-membrane associations in the lignin pathway.

Bassard JE, Richert L, Geerinck J, Renault H, Duval F, Ullmann P, Schmitt M, Meyer E, Mutterer J, Boerjan W, De Jaeger G, Mely Y, Goossens A, Werck-Reichhart D

Plant Cell. 2012 Nov;24(11):4465-82

Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.

Mori M, Schult-Dietrich P, Szafarowicz B, Humbert N, Debaene F, Sanglier-Cianferani S, Dietrich U, Mely Y, Botta M

Virus Res. 2012 Nov;169(2):377-87

Ab initio study of the solvent H-bonding effect on ESIPT reaction and electronic transitions of 3-hydroxychromone derivatives.

Kenfack CA, Klymchenko AS, Duportail G, Burger A, Mely Y

Phys Chem Chem Phys. 2012 Jul 7;14(25):8910-8

The structure of HBsAg particles is not modified upon their adsorption on aluminium hydroxide gel.

Greiner VJ, Ronzon F, Larquet E, Desbat B, Esteves C, Bonvin J, Greco F, Manin C, Klymchenko AS, Mely Y

Vaccine. 2012 Jul 27;30(35):5240-5

A universal nucleoside with strong two-band switchable fluorescence and sensitivity to the environment for investigating DNA interactions.

Dziuba D, Postupalenko VY, Spadafora M, Klymchenko AS, Guerineau V, Mely Y, Benhida R, Burger A

J Am Chem Soc. 2012 Jun 20;134(24):10209-13

Sensing micelle hydration by proton-transfer dynamics of a 3-hydroxychromone dye: role of the surfactant headgroup and chain length.

Das R, Duportail G, Richert L, Klymchenko A, Mely Y

Langmuir. 2012 May 8;28(18):7147-59

A FRET-based probe with a chemically deactivatable quencher.

Leriche G, Budin G, Darwich Z, Weltin D, Mely Y, Klymchenko AS, Wagner A

Chem Commun (Camb). 2012 Mar 28;48(26):3224-6

Analysis of the RNA chaperoning activity of the hepatitis C virus core protein on the conserved 3'X region of the viral genome.

Sharma KK, de Rocquigny H, Darlix JL, Lavergne JP, Penin F, Lessinger JM, Mely Y

Nucleic Acids Res. 2012 Mar;40(6):2540-53

Quantification of local hydration at the surface of biomolecules using dual-fluorescence labels.

Pivovarenko VG, Zamotaiev OM, Shvadchak VV, Postupalenko VY, Klymchenko AS, Mely Y

J Phys Chem A. 2012 Mar 29;116(12):3103-9

Characterization of the inhibition mechanism of HIV-1 nucleocapsid protein chaperone activities by methylated oligoribonucleotides.

Avilov SV, Boudier C, Gottikh M, Darlix JL, Mely Y

Antimicrob Agents Chemother. 2012 Feb;56(2):1010-8

Dipolar 3-methoxychromones as bright and highly solvatochromic fluorescent dyes.

Kucherak OA, Richert L, Mely Y, Klymchenko AS

Phys Chem Chem Phys. 2012 Feb 21;14(7):2292-300

Identification of a thermally activated process in the Cy3 photobleaching mechanism.

Jouonang AL, Didier P, Mely Y

Phys Chem Chem Phys. 2012 Feb 7;14(5):1585-8

Lactose-ornithine bolaamphiphiles for efficient gene delivery in vitro.

Jain N, Goldschmidt V, Oncul S, Arntz Y, Duportail G, Mely Y, Klymchenko AS

Int J Pharm. 2012 Feb 28;423(2):392-400

A new microfluidic setup for precise control of the polymer nanoprecipitation process and lipophilic drug encapsulation.

Anton N, Bally F, Serra CA, Ali A, Arntz Y, Mely Y, Zhao MJ, Marchioni E, Jakhmola A, Vandamme TF

. 2012;8(41):10628-35.

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.

Vercruysse T, Basta B, Dehaen W, Humbert N, Balzarini J, Debaene F, Sanglier-Cianferani S, Pannecouque C, Mely Y, Daelemans D

Retrovirology. 2012 Nov 12;9:95

Highly lipophilic fluorescent dyes in nano-emulsions: towards bright non-leaking nano-droplets.

Klymchenko AS, Roger E, Anton N, Anton H, Shulov I, Vermot J, Mely Y, Vandamme TF

. 2012;2(31):11876-86.

Intrinsic nucleic acid dynamics modulates HIV-1 nucleocapsid protein binding to its targets.

Bazzi A, Zargarian L, Chaminade F, De Rocquigny H, Rene B, Mely Y, Fosse P, Mauffret O

PLoS One. 2012;7(6):e38905

Analysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides.

Guichard C, Ivanyi-Nagy R, Sharma KK, Gabus C, Marc D, Mely Y, Darlix JL

Nucleic Acids Res. 2011 Oct;39(19):8544-58

Characterization of the mechanisms of HIV-1 Vpr(52-96) internalization in cells.

Greiner VJ, Shvadchak V, Fritz J, Arntz Y, Didier P, Frisch B, Boudier C, Mely Y, de Rocquigny H

Biochimie. 2011 Oct;93(10):1647-58

Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein.

Kanevsky I, Chaminade F, Chen Y, Godet J, Rene B, Darlix JL, Mely Y, Mauffret O, Fosse P

Nucleic Acids Res. 2011 Oct;39(18):8148-62

Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.

Godet J, Ramalanjaona N, Sharma KK, Richert L, de Rocquigny H, Darlix JL, Duportail G, Mely Y

Nucleic Acids Res. 2011 Aug;39(15):6633-45

Flexible nature and specific functions of the HIV-1 nucleocapsid protein.

Darlix JL, Godet J, Ivanyi-Nagy R, Fosse P, Mauffret O, Mely Y

J Mol Biol. 2011 Jul 22;410(4):565-81.

Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.

Grigorov B, Bocquin A, Gabus C, Avilov S, Mely Y, Agopian A, Divita G, Gottikh M, Witvrouw M, Darlix JL

Nucleic Acids Res. 2011 Jul;39(13):5586-96

Monitoring membrane binding and insertion of peptides by two-color fluorescent label.

Postupalenko VY, Shvadchak VV, Duportail G, Pivovarenko VG, Klymchenko AS, Mely Y

Biochim Biophys Acta. 2011 Jan;1808(1):424-32

Structure and Behavior of Polydiacetylene-Based Micelles.

Perino A, Klymchenko A, Morere A, Contal E, Rameau A, Guenet JM, Mely Y, Wagner A

. 2011 Jan 18;212(2):111-7.

Biophysical studies of the nucleic acid chaperone properties of the HIV-1 nucleocapsid protein.

Godet J, Mely Y

RNA Biol. 2010 Nov-Dec;7(6):687-99

New Unsymmetrical Bolaamphiphiles: Synthesis, Assembly with DNA, and Application for Gene Delivery.

Jain N, Arntz Y, Goldschmidt V, Duportail G, Mely Y, Klymchenko AS

Bioconjug Chem. 2010 Nov 17;21(11):2110-8

A family of plasmodesmal proteins with receptor-like properties for plant viral movement proteins.

Amari K, Boutant E, Hofmann C, Schmitt-Keichinger C, Fernandez-Calvino L, Didier P, Lerich A, Mutterer J, Thomas CL, Heinlein M, Mély Y, Maule AJ, Ritzenthaler C

PLoS Pathog.. 2010 Sep;6(9):e1001119

HIV-1 viral protein r: from structure to function.

Fritz JV, Briant L, Mely Y, Bouaziz S, de Rocquigny H

Future Virol. 2010 Sep;5(5):607-25.

Behavior of plant plasma membranes under hydrostatic pressure as monitored by fluorescent environment-sensitive probes

Roche Y, Klymchenko AS, Gerbeau-Pissot P, Gervais P, Mely Y, Simon-Plas F, Perrier-Cornet JM

Biochim Biophys Acta. 2010 Aug;1798(8):1601-7

Characterization of the lipid and protein organization in HBsAg viral particles by steady-state and time-resolved fluorescence spectroscopy.

Greiner VJ, Egele C, Oncul S, Ronzon F, Manin C, Klymchenko A, Mely Y

Biochimie. 2010 Aug;92(8):994-1002

Liquid ordered phase in cell membranes evidenced by a hydration-sensitive probe: effects of cholesterol depletion and apoptosis.

Oncul S, Klymchenko AS, Kucherak OA, Demchenko AP, Martin S, Dontenwill M, Arntz Y, Didier P, Duportail G, Mely Y

Biochim Biophys Acta. 2010 Jul;1798(7):1436-43

The Mechanism of HIV-1 Tat-Directed Nucleic Acid Annealing Supports its Role in Reverse Transcription.

Boudier C, Storchak R, Sharma KK, Didier P, Follenius-Wund A, Muller S, Darlix JL, Mely Y

J Mol Biol. 2010 Jul 16;400(3):487-501

Kinetic analysis of the nucleic acid chaperone activity of the Hepatitis C virus core protein.

Sharma KK, Didier P, Darlix JL, de Rocquigny H, Bensikaddour H, Lavergne JP, Penin F, Lessinger JM, Mely Y

Nucleic Acids Res. 2010 Jun;38(11):3632-42

Fluorescent protein recruitment assay for demonstration and analysis of in vivo protein interactions in plant cells and its application to Tobacco mosaic virus movement protein.

Boutant E, Didier P, Niehl A, Mely Y, Ritzenthaler C, Heinlein M

Plant J. 2010 Apr 1;62(1):171-7

Inhibition of HIV-1 Replication by a Bis-Thiadiazolbenzene-1,2-Diamine That Chelates Zinc Ions from Retroviral Nucleocapsid Zinc Fingers.

Pannecouque C, Szafarowicz B, Volkova N, Bakulev V, Dehaen W, Mely Y, Daelemans D

Antimicrob Agents Chemother. 2010 Apr;54(4):1461-8

Switchable Nile Red-Based Probe for Cholesterol and Lipid Order at the Outer Leaflet of Biomembranes.

Kucherak OA, Oncul S, Darwich Z, Yushchenko DA, Arntz Y, Didier P, Mely Y, Klymchenko AS

J Am Chem Soc. 2010 Apr 7;132(13):4907-16

Fluorescence Lifetime Tuning-A Novel Approach to Study Flip-Flop Kinetics in Supported Phospholipid Bilayers.

Kulakowska A, Jurkiewicz P, Sykora J, Benda A, Mely Y, Hof M

J Fluoresc. 2010 Mar;20(2):563-9

Fluorene Analogues of Prodan with Superior Fluorescence Brightness and Solvatochromism.

Kucherak OA, Didier P, Mely Y, Klymchenko AS

J Phys Chem Lett. 2010 Feb 4;1(3):616-20.

HIV-1 Vpr Oligomerization but Not That of Gag Directs the Interaction between Vpr and Gag

Fritz JV, Dujardin D, Godet J, Didier P, De Mey J, Darlix JL, Mely Y, de Rocquigny H

J Virol. 2010 Feb;84(3):1585-96

Boron Containing Two-Photon Absorbing Chromophores. 2. Fine Tuning of the One- and Two-Photon Photophysical Properties of Pyrazabole Based Fluorescent Bioprobes.

Hayek A, Bolze F, Bourgogne C, Baldeck PL, Didier P, Arntz Y, Mely Y, Nicoud JF

Inorg Chem. 2009 Oct 5;48(19):9112-9

Efficient Synthesis of Ratiometric Fluorescent Nucleosides Featuring 3-Hydroxychromone Nucleobases.

Spadafora M, Postupalenko VY, Shvadchak VV, Klymchenko AS, Mely Y, Burger A, Benhida R

Tetrahedron. 2009 Sep 12;65(37):7809-16.

3-Hydroxybenzo[g]quinolones: dyes with red-shifted absorption and highly resolved dual emission.

Bilokin MD, Shvadchak VV, Yushchenko DA, Klymchenko AS, Duportail G, Mely Y, Pivovarenko VG

Tetrahedron Lett. 2009 Aug 19;50(33):4714-9.

Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process.

Ilien B, Glasser N, Clamme JP, Didier P, Piemont E, Chinnappan R, Daval SB, Galzi JL, Mely Y

J Biol Chem. 2009 Jul 17;284(29):19533-43

Monitoring Biophysical Properties of Lipid Membranes by Environment-Sensitive Fluorescent Probes.

Demchenko AP, Mely Y, Duportail G, Klymchenko AS

Biophys J. 2009 May 6;96(9):3461-70

Two-Photon Two-Focus Fluorescence Correlation Spectroscopy with a Tunable Distance Between the Excitation Volumes.

Didier P, Godet J, Mely Y

J Fluoresc. 2009 May;19(3):561-5

Site-Specific Characterization of HIV-1 Nucleocapsid Protein Binding to Oligonucleotides with Two Binding Sites.

Avilov SV, Godet J, Piemont E, Mely Y

Biochemistry. 2009 Mar 24;48(11):2422-30

Sensing peptide-oligonucleotide interactions by a two-color fluorescence label: application to the HIV-1 nucleocapsid protein.

Shvadchak VV, Klymchenko AS, de Rocquigny H, Mely Y

Nucleic Acids Res. 2009 Feb;37(3):e25

Visualization of lipid domains in giant unilamellar vesicles using an environment-sensitive membrane probe based on 3-hydroxyflavone.

Klymchenko AS, Oncul S, Didier P, Schaub E, Bagatolli L, Duportail G, Mely Y

Biochim Biophys Acta. 2009 Feb;1788(2):495-9

Improved push-pull-push E-Bodipy fluorophores for two-photon cell-imaging.

Didier P, Ulrich G, Mely Y, Ziessel R

Org Biomol Chem. 2009 Sep 21;7(18):3639-42

Local environment perturbations in alpha(1)-antitrypsin monitored by a ratiometric fluorescent label.

Boudier C, Klymchenko AS, Mely Y, Follenius-Wund A

Photochem Photobiol Sci. 2009 Jun;8(6):814-21

Combining Fluorescence Lifetime and Polarization Microscopy to Discriminate Phase Separated Domains in Giant Unilamellar Vesicles.

Haluska CK, Schroder AP, Didier P, Heissler D, Duportail G, Mely Y, Marques CM

Biophys J. 2008 Dec 15;95(12):5737-47

HIV-1 Nucleocapsid Traps Reverse Transcriptase on Nucleic Acid Substratest.

Grohmann D, Godet J, Mely Y, Darlix JL, Restle T

Biochemistry. 2008 Nov 18;47(46):12230-40

How the HIV-1 Nucleocapsid Protein Binds and Destabilises the (-)Primer Binding Site During Reverse Transcription.

Bourbigot S, Ramalanjaona N, Boudier C, Salgado GFJ, Roques BP, Mely Y, Bouaziz S, Morellet N

J Mol Biol. 2008 Nov 28;383(5):1112-28

Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging.

Fritz JV, Didier P, Clamme JP, Schaub E, Muriaux D, Cabanne C, Morellet N, Bouaziz S, Darlix JL, Mely Y, de Rocquigny H

Retrovirology. 2008 Sep 22;5:87

Investigating the mechanism of the nucleocapsid protein chaperoning of the second strand transfer during HIV-1 DNA synthesis.

Ramalanjaona N, de Rocquigny H, Millet A, Ficheux D, Darlix JL, Mely Y

J Mol Biol. 2007 Dec 7;374(4):1041-53

The single-finger nucleocapsid protein of Moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing

Egele C, Piemont E, Didier P, Ficheux D, Roques B, Darlix JL, de Rocquigny H, Mely Y

Biochemistry. 2007 Dec 18;46(50):14650-62

Tuning excited state intramolecular proton transfer in 3-hydroxyflavone derivative by reaction of its isothiocyanate group with an amine.

Klymchenko AS, Yushchenko DA, Mely Y

J Photochem Photobiol A-chem. 2007 Dec 15;192(2-3):93-7.

Sensing of adenosine-5'-triphosphate anion in aqueous solutions and mitochondria by a fluorescent 3-hydroxyflavone dye.

Yushchenko DA, Vadzyuk OB, Kosterin SO, Duportail G, Mely Y, Pivovarenko VG

Anal Biochem. 2007 Oct 15;369(2):218-25

Steric control of the excited-state intramolecular proton transfer in 3-hydroxyquinolones: Steady-state and time-resolved fluorescence study.

Yushchenko DA, Shvadchak VV, Klymchenko AS, Duportail G, Pivovarenko VG, Mely Y

J Phys Chem A. 2007 Sep 20;111(37):8986-92

Fluorescent dyes undergoing intramolecular proton transfer with improved sensitivity to surface charge in lipid bilayers.

M'Baye G, Klymchenko AS, Yushchenko DA, Shvadchak VV, Ozturk T, Mely Y, Duportail G

Photochem Photobiol Sci. 2007 Jan;6(1):71-6

Excited-state properties and transitions of fluorescent 8-vinyl adenosine in DNA.

Kenfack CA, Burger A, Mely Y

J Phys Chem B. 2006 Dec 28;110(51):26327-36.

A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein.

Raja C, Ferner J, Dietrich U, Avilov S, Ficheux D, Darlix JL, de Rocquigny H, Schwalbe H, Mely Y

Biochemistry. 2006 Aug 1;45(30):9254-65.

Physicochemical properties of low molecular weight alkylated chitosans: A new class of potential nonviral vectors for gene delivery.

Ercelen S, Zhang X, Duportail G, Grandfils C, Desbrieres J, Karaeva S, Tikhonov V, Mely Y, Babak V

Colloids Surf B Biointerfaces. 2006 Aug 15;51(2):140-8

During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem.

Godet J, de Rocquigny H, Raja C, Glasser N, Ficheux D, Darlix JL, Mely Y

J Mol Biol. 2006 Mar 10;356(5):1180-92

Synthesis and fluorescence properties of 2-aryl-3-hydroxyquinolones, a new class of dyes displaying dual fluorescence.

Yushchenko DA, Bilokin' MD, Pyvovarenko OV, Duportail G, Mely Y, Pivovarenko VG

Tetrahedron Lett. 2006 Feb 6;47(6):905-8.

2-Aryl-3-hydroxyquinolones, a new class of dyes with solvent dependent dual emission due to excited state intramolecular proton transfer.

Yushchenko DA, Shvadchak VV, Klymchenko AS, Duportail G, Mely Y, Pivovarenko VG

New J Chem. 2006;30(5):774-81.

Membrane dipole potential as measured by ratiometric 3-hydroxyflavone fluorescence probes: Accounting for hydration effects.

M'Baye G, Shynkar VV, Klymchenko AS, Mely Y, Duportail G

J Fluoresc. 2006 Jan;16(1):35-42

Investigation by fluorescence correlation spectroscopy of the chaperoning interactions of HIV-1 nucleocapsid protein with the viral DNA initiation sequences.

Egele C, Schaub E, Piemont E, de Rocquigny H, Mely Y

C R Biol. 2005 Dec;328(12):1041-51

Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.

Beltz H, Clauss C, Piemont E, Ficheux D, Gorelick RJ, Roques B, Gabus C, Darlix JL, de Rocquigny H, Mely Y

J Mol Biol. 2005 May 20;348(5):1113-26

The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.

Bourbigot S, Beltz H, Denis J, Morellet N, Roques BP, Mely Y, Bouaziz S

Biochem J. 2005 Apr 15;387(Pt 2):333-41.

8-vinyl-deoxyadenosine, an alternative fluorescent nucleoside analog to 2'-deoxyribosyl-2-aminopurine with improved properties.

Gaied NB, Glasser N, Ramalanjaona N, Beltz H, Wolff P, Marquet R, Burger A, Mely Y

Nucleic Acids Res. 2005;33(3):1031-9.

Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate.

Courrier HM, Krafft MP, Butz N, Porté C, Frossard N, Rémy-Kristensen A, Mély Y, Pons F, Vandamme TF

Biomaterials. 2003 Feb;24(4):689-96

[The first stage of transmission of an epigenetic character followed by fluorescence].

Bronner C, Mousli M, Burger A, Mély Y

Med Sci (Paris). ;33(8-9):717-719

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