Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons.
Fiche publication
Date publication
août 2012
Journal
Biomaterials
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUMORTIER Hélène, Dr BIANCO Alberto
Tous les auteurs :
Lamanna G, Russier J, Dumortier H, Bianco A
Lien Pubmed
Résumé
We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.
Mots clés
Animals, Anti-Inflammatory Agents, administration & dosage, Cell Line, Cell Survival, drug effects, Dendrimers, administration & dosage, Drug Synergism, Ibuprofen, administration & dosage, Macrophages, cytology, Mice
Référence
Biomaterials. 2012 Aug;33(22):5610-7