2007 - Porteur du projet : Dr RIO Marie-Christine - Partenaires : Pr ABECASSIS Joseph, Pr BIREMBAUT Philippe, Pr DIEBOLD Marie-Danièle, Dr FREUND Jean-Noël, Dr GAUB Marie-Pierre, Dr GHNASSIA Jean-Pierre, Dr GUERIN Eric, Pr HAIECH Jacques, Pr JEANNESSON Pierre, Dr KASTNER Philippe, Pr MANFAIT Michel, Pr MAQUART François-Xavier, Dr NEUVILLE Agnès, Dr OREND Gertraud, Pr PLENAT François, Dr VAN DORSSELAER Alain, Pr VIGNAUD Jean-Michel, Dr VOEGEL Jean-Claude, Dr WASYLYK Bohdan

Rôle immunologique des HSPs extracellulaires lors de la transplantation des cellules souches hématopoïétiques (IHSP-07)

2007 - Porteur du projet : Dr GARRIDO Carmen - Partenaires : Pr HAIECH Jacques, Pr TIBERGHIEN Pierre

Publications

[For a good understanding and use of the term "organoids"].

Chneiweiss H, Dubart-Kupperschmitt A, Duclos-Vallée JC, Clément B, Flacher V, Galzi JL, Gidrol X, Goureau O, Guasch G, Haiech J, Lemaitre C, Mahé MM, Martin S, Poulain L, Sebastiani C, Vergnolle N, Yates F

Med Sci (Paris). 2023 11;39(11):876-878

At the crossroads of epidemiology and biology: Bridging the gap between SARS-CoV-2 viral strain properties and epidemic wave characteristics.

Poydenot F, Lebreton A, Haiech J, Andreotti B

Biochimie. 2023 03 15;:

Risk assessment for long- and short-range airborne transmission of SARS-CoV-2, indoors and outdoors.

Poydenot F, Abdourahamane I, Caplain E, Der S, Haiech J, Jallon A, Khoutami I, Loucif A, Marinov E, Andreotti B

PNAS Nexus. 2022 11;1(5):pgac223

[Explore the history of artificial intelligence, to better define and understand it].

Haiech J

Med Sci (Paris). 2020 Oct;36(10):919-923

Facts and conjectures on calmodulin and its cousin proteins, parvalbumin and troponin C.

Haiech J, Moreau M, Leclerc C, Kilhoffer MC

Biochim Biophys Acta Mol Cell Res. 2019 Feb 1;:

ECS meeting.

Haiech J, Heizmann CW, Krebs J

Biochim Biophys Acta Mol Cell Res. 2019 Jan 14;:

Using Data Mining to Explore Calmodulin Bibliography.

Haiech J, Kilhoffer MC

Methods Mol. Biol.. 2019 ;1929:3-14

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.

Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D, Haiech J, Knehans T, Rognan D, Heissler D, Marsol C, Villa P, Galzi JL, Hibert M, Frossard N, Bonnet D

J. Med. Chem.. 2018 Aug 14;:

Quiescence status of glioblastoma stem-like cells involves remodelling of Ca signalling and mitochondrial shape.

Aulestia FJ, Néant I, Dong J, Haiech J, Kilhoffer MC, Moreau M, Leclerc C

Sci Rep. 2018 Jun 27;8(1):9731

WNK1 kinase and its partners Akt, SGK1 and NBC-family Na/HCO3 cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.

Chen W, Zebaze LN, Dong J, Chézeau L, Inquimbert P, Hugel S, Niu S, Bihel F, Boutant E, Réal E, Villa P, Junier MP, Chneiweiss H, Hibert M, Haiech J, Kilhoffer MC, Zeniou M

Oncotarget. 2018 Jun 5;9(43):27197-27219

Efficient Modeling and Simulation of Space-Dependent Biological Systems.

Rosati E, Madec M, Kammerer JB, Hébrard L, Lallement C, Haiech J

J. Comput. Biol.. 2018 May 9;:

Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.

Bogeas A, Morvan-Dubois G, El-Habr EA, Lejeune FX, Defrance M, Narayanan A, Kuranda K, Burel-Vandenbos F, Sayd S, Delaunay V, Dubois LG, Parrinello H, Rialle S, Fabrega S, Idbaih A, Haiech J, Bièche I, Virolle T, Goodhardt M, Chneiweiss H, Junier MP

Acta Neuropathol.. 2018 Feb;135(2):267-283

Ca-Dependent Transcriptional Repressors KCNIP and Regulation of Prognosis Genes in Glioblastoma.

Néant I, Haiech J, Kilhoffer MC, Aulestia FJ, Moreau M, Leclerc C

Front Mol Neurosci. 2018 ;11:472

The adaptors Grb10 and Grb14 are calmodulin-binding proteins.

García-Palmero I, Pompas-Veganzones N, Villalobo E, Gioria S, Haiech J, Villalobo A

FEBS Lett.. 2017 Mar;:

[Application of microelectronics CAD tools to synthetic biology].

Madec M, Haiech J, Rosati É, Rezgui A, Gendrault Y, Lallement C

Med Sci (Paris). 2017 Feb;33(2):159-168

Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling.

Dong J, Aulestia FJ, Assad Kahn S, Zeniou M, Dubois LG, El-Habr EA, Daubeuf F, Tounsi N, Cheshier SH, Frossard N, Junier MP, Chneiweiss H, Néant I, Moreau M, Leclerc C, Haiech J, Kilhoffer MC

Biochim. Biophys. Acta. 2017 Jan;:

Modeling and simulation of biological systems using SPICE language.

Madec M, Lallement C, Haiech J

PLoS ONE. 2017 ;12(8):e0182385

GeNeDA: An Open-Source Workflow for Design Automation of Gene Regulatory Networks Inspired from Microelectronics.

Madec M, Pecheux F, Gendrault Y, Rosati E, Lallement C, Haiech J

J. Comput. Biol.. 2016 Oct;23(10):841-55

Calcium and Cell Fate.

Capiod T, Haiech J, Heizmann CW, Krebs J, Mignen O

Biochim. Biophys. Acta. 2016 Jun;1863(6 Pt B):1335-6

The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.

Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H

EMBO Mol Med. 2016 05;8(5):511-26

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy.

Chen W, Dong J, Haiech J, Kilhoffer MC, Zeniou M

Stem Cells Int. 2016 ;2016:1740936

New Fluorescein Precursors for Live Bacteria Detection.

Guilini C, Baehr C, Schaeffer E, Gizzi P, Rufi F, Haiech J, Weiss E, Bonnet D, Galzi JL

Anal Chem. 2015 Sep 1;87(17):8858-66

Preface.

Haiech J, Heizmann CW, Krebs J

Biochim Biophys Acta. 2015 Sep;1853(9):1919-20

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity.

Abboud D, Daubeuf F, Do QT, Utard V, Villa P, Haiech J, Bonnet D, Hibert M, Bernard P, Galzi JL, Frossard N

Sci Rep. 2015 Oct 7;5:14746

Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

Zeniou M, Feve M, Mameri S, Dong J, Salome C, Chen W, El-Habr EA, Bousson F, Sy M, Obszynski J, Boh A, Villa P, Assad Kahn S, Didier B, Bagnard D, Junier MP, Chneiweiss H, Haiech J, Hibert M, Kilhoffer MC

PLoS One. 2015 Aug 13;10(8):e0134793

Glioblastoma and calcium signaling--analysis of calcium toolbox expression.

Robil N, Petel F, Kilhoffer MC, Haiech J

Int. J. Dev. Biol.. 2015 ;59(7-9):407-15

A general framework improving teaching ligand binding to a macromolecule.

Haiech J, Gendrault Y, Kilhoffer MC, Ranjeva R, Madec M, Lallement C

Biochim Biophys Acta. 2014 Oct;1843(10):2348-55

Calcium signalling as a hub for translational medicine a starting point to model life.

Moreau M, Haiech J

Biochim Biophys Acta. 2014 Oct;1843(10):2283

Modeling biology with HDL languages: a first step toward a genetic design automation tool inspired from microelectronics.

Gendrault Y, Madec M, Lallement C, Haiech J

IEEE Trans Biomed Eng. 2014 Apr;61(4):1231-40

Quantitative structure-property relationship modeling: a valuable support in high-throughput screening quality control.

Ruggiu F, Gizzi P, Galzi JL, Hibert M, Haiech J, Baskin I, Horvath D, Marcou G, Varnek A

Anal Chem. 2014 Mar 4;86(5):2510-20

Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets.

Feve M, Saliou JM, Zeniou M, Lennon S, Carapito C, Dong J, Van Dorsselaer A, Junier MP, Chneiweiss H, Cianferani S, Haiech J, Kilhoffer MC

PLoS One. 2014 Mar 24;9(3):e91519

Generation and behavior characterization of CaMKIIbeta knockout mice.

Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ

PLoS One. 2014 Aug 15;9(8):e105191

A general framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains.

Audran E, Dagher R, Gioria S, Tsvetkov PO, Kulikova AA, Didier B, Villa P, Makarov AA, Kilhoffer MC, Haiech J

Biochim Biophys Acta. 2013 Jul;1833(7):1720-31

[Evolution of biology seen by a biologist: from description to prediction].

Haiech J

Med Sci (Paris). 2013 May;29 Spec No 2:43-6

[Too much evaluation kills evaluation].

Haiech J

Med Sci (Paris). 2013 Feb;29(2):119-20

New aspects of calmodulin-calmodulin binding domains recognition.

Audran E, Dagher R, Gioria S, Kilhoffer MC, Haiech J

Methods Mol Biol. 2013;963:57-72

Personalized medicine and education: the challenge.

Haiech J, Kilhoffer MC

Croat Med J. 2012 Aug;53(4):298-300.

[System biology and synthetic biology modify drug discovery and development].

Haiech J, Ranjeva R, Kilhoffer MC

Med Sci (Paris). 2012 Feb;28(2):207-12

A game-of-life like simulator for design-oriented modeling of BioBricks in synthetic biology.

Madec M, Gendrault Y, Lallement C, Haiech J

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5462-5

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo.

Gasparik V, Daubeuf F, Hachet-Haas M, Rohmer F, Gizzi P, Haiech J, Galzi JL, Hibert M, Bonnet D, Frossard N

. 2012 Jan;3(1):10-4.

Using digital electronic design flow to create a Genetic Design Automation tool.

Gendrault Y, Madec M, Wlotzko V, Andraud M, Lallement C, Haiech J

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5530-3

Revisiting intracellular calcium signaling semantics.

Haiech J, Audran E, Feve M, Ranjeva R, Kilhoffer MC

Biochimie. 2011 Dec;93(12):2029-37

The calcium signal: a universal carrier to code, decode and transduce information.

Haiech J, Moreau M

Biochimie. 2011 Dec;93(12):v.

A general strategy to characterize calmodulin-calcium complexes involved in CaM-target recognition: DAPK and EGFR calmodulin binding domains interact with different calmodulin-calcium complexes.

Dagher R, Peng S, Gioria S, Feve M, Zeniou M, Zimmermann M, Pigault C, Haiech J, Kilhoffer MC

Biochim Biophys Acta. 2011 May;1813(5):1059-67

The 11(th) Meeting of the European Calcium Society.

Haiech J, Heizmann CW, Krebs J

Biochim Biophys Acta. 2011 May;1813(5):908.

The neutralizing ligands to the onslaught of chemokines.

Hachet-Haas M, Bonnet D, Daubeuf F, Hibert M, Haiech J, Frossard N, Galzi JL

. 2011 Mar;319:52-5.

Cryptogein, a fungal elicitor, remodels the phenylpropanoid metabolism of tobacco cell suspension cultures in a calcium-dependent manner.

Amelot N, Carrouche A, Danoun S, Bourque S, Haiech J, Pugin A, Ranjeva R, Grima-Pettenati J, Mazars C, Briere C

Plant Cell Environ. 2011 Jan;34(1):149-61

Identification by high-throughput screening of inhibitors of Schistosomamansoni NAD(+) catabolizing enzyme.

Kuhn I, Kellenberger E, Said-Hassane F, Villa P, Rognan D, Lobstein A, Haiech J, Hibert M, Schuber F, Muller-Steffner H

Bioorg Med Chem. 2010 Nov 15;18(22):7900-10

Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.

Galzi JL, Hachet-Haas M, Bonnet D, Daubeuf F, Lecat S, Hibert M, Haiech J, Frossard N

Pharmacol Ther. 2010 Apr;126(1):39-55

CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors.

Patru C, Romao L, Varlet P, Coulombel L, Raponi E, Cadusseau J, Renault-Mihara F, Thirant C, Leonard N, Berhneim A, Mihalescu-Maingot M, Haiech J, Bieche I, Moura-Neto V, Daumas-Duport C, Junier MP, Chneiweiss H

BMC Cancer. 2010 Feb 24;10:66.

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter.

Zimmermann M, Atmanene C, Xu Q, Fouillen L, Van Dorsselaer A, Bonnet D, Marsol C, Hibert M, Sanglier-Cianferani S, Pigault C, McNamara LK, Watterson DM, Haiech J, Kilhoffer MC

PLoS One. 2010 Nov 30;5(11):e14120.

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

Betzi S, Eydoux C, Bussetta C, Blemont M, Leyssen P, Debarnot C, Ben-Rahou M, Haiech J, Hibert M, Gueritte F, Grierson DS, Romette JL, Guillemot JC, Neyts J, Alvarez K, Morelli X, Dutartre H, Canard B

Antiviral Res. 2009 Oct;84(1):48-59

Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein.

Shvadchak V, Sanglier S, Rocle S, Villa P, Haiech J, Hibert M, Van Dorsselaer A, Mely Y, de Rocquigny H

Biochimie. 2009 Jul;91(7):916-23

Unfolding of rabbit muscle creatine kinase induced by acid. A study using electrospray ionization mass spectrometry, isothermal titration calorimetry, and fluorescence spectroscopy.

Liang Y, Du F, Sanglier S, Zhou BR, Xia Y, Van Dorsselaer A, Maechling C, Kilhoffer MC, Haiech J

J Biol Chem. 2003 Aug 8;278(32):30098-105