2007 - Porteur du projet : Dr RIO Marie-Christine - Partenaires : Pr ABECASSIS Joseph, Pr BIREMBAUT Philippe, Pr DIEBOLD Marie-Danièle, Dr FREUND Jean-Noël, Dr GAUB Marie-Pierre, Dr GHNASSIA Jean-Pierre, Dr GUERIN Eric, Pr HAIECH Jacques, Pr JEANNESSON Pierre, Dr KASTNER Philippe, Pr MANFAIT Michel, Pr MAQUART François-Xavier, Dr NEUVILLE Agnès, Dr OREND Gertraud, Pr PLENAT François, Dr VAN DORSSELAER Alain, Pr VIGNAUD Jean-Michel, Dr VOEGEL Jean-Claude, Dr WASYLYK Bohdan

Novel prostate cancer serum markers - validation and development of ultrasensitive nanobead technology and ELISA screens (PCNANOBEADBIOMARKER)

2007 - Porteur du projet : Dr WASYLYK Bohdan - Partenaires : Pr ABECASSIS Joseph, Dr GHNASSIA Jean-Pierre

Publications

TTLL12 has a potential oncogenic activity, suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated α-tubulin, that can be overcome by molecules identified by screening a compound library.

Deshpande A, Brants J, Wasylyk C, van Hooij O, Verhaegh GW, Maas P, Schalken JA, Wasylyk B

PLoS One. 2024 02 23;19(2):e0296960

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer.

Mourtada J, Thibaudeau C, Wasylyk B, Jung AC

Cells. 2023 12 29;13(1):

A novel ΔNp63-dependent immune mechanism improves prognosis of HPV-related head and neck cancer.

Mourtada J, Lony C, Nicol A, De Azevedo J, Bour C, Macabre C, Roncarati P, Ledrappier S, Schultz P, Borel C, Burgy M, Wasylyk B, Mellitzer G, Herfs M, Gaiddon C, Jung AC

Front Immunol. 2023 10 25;14:1264093

Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on -Driven Oncogenic Addiction.

Job S, Reyniès A, Heller B, Weiss A, Guérin E, Macabre C, Ledrappier S, Bour C, Wasylyk C, Etienne-Selloum N, Brino L, Gaiddon C, Wasylyk B, Jung AC

Cancers (Basel). 2019 Jun 8;11(6):

An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes.

Kurihara C, Nakade K, Pan J, Huang J, Wasylyk B, Obata Y

Biotechnol Rep (Amst). 2016 Dec;12:26-32

XRP44X, an Inhibitor of Ras/Erk Activation of the Transcription Factor Elk3, Inhibits Tumour Growth and Metastasis in Mice.

Semenchenko K, Wasylyk C, Cheung H, Tourrette Y, Maas P, Schalken JA, van der Pluijm G, Wasylyk B

PLoS ONE. 2016 ;11(7):e0159531

Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke.

Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, Mauel S, Breithaupt A, Gruber AD, Wasylyk B, Olson EN, Adams RH, Pichler BJ, Nordheim A

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9914-9

Human Papillomavirus-related tumours of the oropharynx display a lower tumour hypoxia signature.

Hanns E, Job S, Coliat P, Wasylyk C, Ramolu L, Pencreach E, Suarez-Carmona M, Herfs M, Ledrappier S, Macabre C, Abecassis J, Wasylyk B, Jung AC

Oral Oncol. 2015 Jun 26. pii: S1368-8375(15)00237-7

The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.

Robertson ED, Wasylyk C, Ye T, Jung AC, Wasylyk B

PLoS One. 2014 Nov 17;9(11):e113050

Identification of clinically relevant HPV-related HNSCC: in p16 should we trust?

Wasylyk B, Abecassis J, Jung AC

Oral Oncol. 2013 Oct;49(10):e33-7

A poor prognosis subtype of HNSCC is consistently observed across methylome, transcriptome, and miRNome analysis.

Jung AC, Job S, Ledrappier S, Macabre C, Abecassis J, de Reynies A, Wasylyk B

Clin Cancer Res. 2013 Aug 1;19(15):4174-84

CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis.

Jung AC, Guihard S, Krugell S, Ledrappier S, Brochot A, Dalstein V, Job S, de Reynies A, Noel G, Wasylyk B, Clavel C, Abecassis J

Int J Cancer. 2013 Jan 15;132(2):E26-36

The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation.

Guihard S, Ramolu L, Macabre C, Wasylyk B, Noel G, Abecassis J, Jung AC

Int J Oncol. 2012 Oct;41(4):1531-40

c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.

Chen J, Sun WL, Wasylyk B, Wang YP, Zheng H

Anticancer Drugs. 2012 Jan;23(1):98-107.

Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis.

Brants J, Semenchenko K, Wasylyk C, Robert A, Carles A, Zambrano A, Pradeau-Aubreton K, Birck C, Schalken JA, Poch O, de Mey J, Wasylyk B

PLoS One. 2012;7(12):e51258

Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy.

Wasylyk C, Zambrano A, Zhao C, Brants J, Abecassis J, Schalken JA, Rogatsch H, Schaefer G, Pycha A, Klocker H, Wasylyk B

Int J Cancer. 2010 Dec 1;127(11):2542-53.

ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines.

Ayoub C, Wasylyk C, Li Y, Thomas E, Marisa L, Robe A, Roux M, Abecassis J, de Reynies A, Wasylyk B

Br J Cancer. 2010 Aug 24;103(5):715-26

Involvement of net and Hif1alpha in distinct yet intricately linked hypoxia-induced signaling pathways.

Serchov T, Dubois-Pot-Schneider H, Charlot C, Rosl F, Wasylyk B

J Biol Chem. 2010 Jul 9;285(28):21223-32

Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.

Costello P, Nicolas R, Willoughby J, Wasylyk B, Nordheim A, Treisman R

J Immunol. 2010 Jul 15;185(2):1082-92

Epigenetic regulation of p16Ink4a and Arf by JDP2 in cellular senescence.

Nakade K, Wasylyk B, Yokoyama KK

Biomol Concepts. 2010 May 1;1(1):49-58

Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma.

Jung AC, Briolat J, Millon R, de Reyniès A, Rickman D, Thomas E, Abecassis J, Clavel C, Wasylyk B

Int. J. Cancer. 2010 Apr;126(8):1882-94

A review of post-translational modifications and subcellular localization of Ets transcription factors: possible connection with cancer and involvement in the hypoxic response.

Charlot C, Dubois-Pot H, Serchov T, Tourrette Y, Wasylyk B

Methods Mol Biol. 2010;647:3-30.

Regulation of MCP-1 chemokine transcription by p53.

Hacke K, Rincon-Orozco B, Buchwalter G, Siehler SY, Wasylyk B, Wiesmuller L, Rosl F

Mol Cancer. 2010 Apr 20;9:82.

JDP2 (Jun Dimerization Protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescence.

Nakade K, Pan J, Yamasaki T, Murata T, Wasylyk B, Yokoyama KK

J Biol Chem. 2009 Apr 17;284(16):10808-17

Complexity in transcription control at the activation domain-mediator interface.

Balamotis MA, Pennella MA, Stevens JL, Wasylyk B, Belmont AS, Berk AJ

Sci Signal. 2009 May 5;2(69):ra20.

Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays.

Rickman DS, Millon R, De Reynies A, Thomas E, Wasylyk C, Muller D, Abecassis J, Wasylyk B

Oncogene. 2008 Nov 20;27(51):6607-22

Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.

Wasylyk C, Zheng H, Castell C, Debussche L, Multon MC, Wasylyk B

Cancer Res. 2008 Mar 1;68(5):1275-83.

The ternary complex factor Net/Elk-3 participates in the transcriptional response to hypoxia and regulates HIF-1 alpha.

Gross C, Dubois-Pot H, Wasylyk B

Oncogene. 2008 Feb 21;27(9):1333-41

High level protein expression in mammalian cells using a safe viral vector: modified vaccinia virus Ankara.

Hebben M, Brants J, Birck C, Samama JP, Wasylyk B, Spehner D, Pradeau K, Domi A, Moss B, Schultz P, Drillien R

Protein Expr Purif. 2007 Dec;56(2):269-78

A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH.

Wicker N, Carles A, Mills IG, Wolf M, Veerakumarasivam A, Edgren H, Boileau F, Wasylyk B, Schalken JA, Neal DE, Kallioniemi O, Poch O

BMC Genomics. 2007 Mar 29;8:84.

Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.

Muller D, Millon R, Theobald S, Hussenet T, Wasylyk B, du Manoir S, Abecassis J

Br J Cancer. 2006 Apr 10;94(7):1041-4.

hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis.

Kogan I, Goldfinger N, Milyavsky M, Cohen M, Shats I, Dobler G, Klocker H, Wasylyk B, Voller M, Aalders T, Schalken JA, Oren M, Rotter V

Cancer Res. 2006 Apr 1;66(7):3531-40.

Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display.

Carles A, Millon R, Cromer A, Ganguli G, Lemaire F, Young J, Wasylyk C, Muller D, Schultz I, Rabouel Y, Dembele D, Zhao C, Marchal P, Ducray C, Bracco L, Abecassis J, Poch O, Wasylyk B

Oncogene. 2006 Mar 16;25(12):1821-31.

Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours.

Seghatoleslam A, Zambrano A, Millon R, Ganguli G, Argentini M, Cromer A, Abecassis J, Wasylyk B

Biochem Biophys Res Commun. 2006 Jan 6;339(1):422-9

The ternary complex factor Net regulates cell migration through inhibition of PAI-1 expression.

Buchwalter G, Gross C, Wasylyk B

Mol Cell Biol. 2005 Dec;25(24):10853-62.

Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells.

van Riggelen J, Buchwalter G, Soto U, De-Castro Arce J, Hausen HZ, Wasylyk B, Rosl F

J Biol Chem. 2005 Feb 4;280(5):3286-94

Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net.

Wasylyk C, Criqui-Filipe P, Wasylyk B

Oncogene. 2005 Jan 27;24(5):820-8.

Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma.

Lemaire F, Millon R, Muller D, Rabouel Y, Bracco L, Abecassis J, Wasylyk B

Br J Cancer. 2004 Jul 19;91(2):258-61.

Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors.

Sengupta S, Wasylyk B

Ann N Y Acad Sci. 2004 Jun;1024:54-71.

Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis.

Cromer A, Carles A, Millon R, Ganguli G, Chalmel F, Lemaire F, Young J, Dembele D, Thibault C, Muller D, Poch O, Abecassis J, Wasylyk B

Oncogene. 2004 Apr 1;23(14):2484-98.

Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.

Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, Geant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3510-5