2007 - Porteur du projet : Dr RIO Marie-Christine - Partenaires : Pr ABECASSIS Joseph, Pr BIREMBAUT Philippe, Pr DIEBOLD Marie-Danièle, Dr FREUND Jean-Noël, Dr GAUB Marie-Pierre, Dr GHNASSIA Jean-Pierre, Dr GUERIN Eric, Pr HAIECH Jacques, Pr JEANNESSON Pierre, Dr KASTNER Philippe, Pr MANFAIT Michel, Pr MAQUART François-Xavier, Dr NEUVILLE Agnès, Dr OREND Gertraud, Pr PLENAT François, Dr VAN DORSSELAER Alain, Pr VIGNAUD Jean-Michel, Dr VOEGEL Jean-Claude, Dr WASYLYK Bohdan

Publications

Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo.

El Omar R, Abdellaoui N, Coulibaly ST, Fontenille L, Lanza F, Gachet C, Freund JN, Negroni M, Kissa K, Tavian M

Cell Death Dis. 2024 05 1;15(5):305

CD32 captures committed haemogenic endothelial cells during human embryonic development.

Scarfò R, Randolph LN, Abou Alezz M, El Khoury M, Gersch A, Li ZY, Luff SA, Tavosanis A, Ferrari Ramondo G, Valsoni S, Cascione S, Didelon E, Passerini L, Amodio G, Brandas C, Villa A, Gregori S, Merelli I, Freund JN, Sturgeon CM, Tavian M, Ditadi A

Nat Cell Biol. 2024 04 9;:

MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.

Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, Kraft P, Herterich S, Mamtimin M, Pinarci A, Beck S, Stritt S, Chao H, Ren P, Freund JN, Klemann C, Ringshausen FC, Heemskerk JWM, Dietrich A, Nieswandt B, Stoll G, Gudermann T, Braun A

Arterioscler Thromb Vasc Biol. 2023 06 29;:

General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.

Säisä-Borreill S, Davidson G, Kleiber T, Thevenot A, Martin E, Mondot S, Blottière H, Helleux A, Mengus G, Plateroti M, Duluc I, Davidson I, Freund JN

Cell Death Differ. 2023 01 13;:

The appendix orchestrates T-cell mediated immunosurveillance in colitis-associated cancer.

Collard MK, Tourneur-Marsille J, Uzzan M, Albuquerque M, Roy M, Dumay A, Freund JN, Hugot JP, Guedj N, Treton X, Panis Y, Ogier-Denis E

Cell Mol Gastroenterol Hepatol. 2022 11 1;:

Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions.

Giolito MV, La Rosa T, Farhat D, Bodoirat S, Guardia GDA, Domon-Dell C, Galante PAF, Freund JN, Plateroti M

Mol Oncol. 2022 07 31;:

Concurrent CDX2 cis-deregulation and UBTF-ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.

Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye-Eude A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay TT, Hunault-Berger MM, Pflumio F, Freund JN, Lobry C, Lheritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E

Blood. 2022 Mar 22;:

CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer.

Delhorme JB, Bersuder E, Terciolo C, Vlami O, Chenard MP, Martin E, Rohr S, Brigand C, Duluc I, Freund JN, Gross I

Biomed Pharmacother. 2022 Jan 17;147:112630

Mesalazine initiates an anti-oncogenic β-catenin / MUCDHL negative feed-back loop in colon cancer cells by cell-specific mechanisms.

Bersuder E, Terciolo C, Lechevrel M, Martin E, Quesnelle C, Freund JN, Reimund JM, Gross I

Biomed Pharmacother. 2021 Dec 17;146:112543

CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors.

Priya S, Kaur E, Kulshrestha S, Pandit A, Gross I, Kumar N, Agarwal H, Khan A, Shyam R, Bhagat P, Prabhu JS, Nagarajan P, Deo SVS, Bajaj A, Freund JN, Mukhopadhyay A, Sengupta S

J Cell Sci. 2021 Aug 1;134(15):

CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors.

Priya S, Kaur E, Kulshrestha S, Pandit A, Gross I, Kumar N, Agarwal H, Khan A, Shyam R, Bhagat P, Prabhu JS, Nagarajan P, Deo SVS, Bajaj A, Freund JN, Mukhopadhyay A, Sengupta S

J Cell Sci. 2021 Jul 19;:

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition.

Galland A, Gourain V, Habbas K, Güler Y, Martin E, Ebel C, Tavian M, Vallat L, Chenard MP, Mauvieux L, Freund JN, Duluc I, Domon-Dell C

Mol Oncol. 2021 May 6;:

CDX2 regulates ACE expression in blood development and leukemia cells.

El Omar R, Julien E, Biasch K, Guffroy B, Lioure B, Vallat L, Gross I, Domon-Dell C, Lanza F, Gachet C, Negroni M, Freund JN, Tavian M

Blood Adv. 2021 Apr 13;5(7):2012-2016

Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia.

Schleiss C, Carapito R, Fornecker LM, Muller L, Paul N, Tahar O, Pichot A, Tavian M, Nicolae A, Miguet L, Mauvieux L, Herbrecht R, Cianferani S, Freund JN, Carapito C, Maumy-Bertrand M, Bahram S, Bertrand F, Vallat L

Leukemia. 2021 Apr 8;:

The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway.

Godart M, Frau C, Farhat D, Giolito MV, Jamard C, Le Nevé C, Freund JN, Penalva LO, Sirakov M, Plateroti M

Development. 2021 Mar 23;:

Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy.

Frau C, Jamard C, Delpouve G, Guardia GDA, Machon C, Pilati C, Le Neve C, Laurent-Puig P, Guitton J, Galante PAF, Penalva LO, Freund JN, de la Fouchardière C, Plateroti M

Cancer Res. 2021 Mar 19;:

Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells.

Julien E, Biasch K, El Omar R, Freund JN, Gachet C, Lanza F, Tavian M

Stem Cells. 2021 Jan 21;:

A Core Response to the CDX2 Homeoprotein During Development and in Pathologies.

Gourain V, Duluc I, Domon-Dell C, Freund JN

Front Genet. 2021 ;12:744165

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms.

Beck M, Baranger M, Moufok-Sadoun A, Bersuder E, Hinkel I, Mellitzer G, Martin E, Marisa L, Duluc I, de Reynies A, Gaiddon C, Freund JN, Gross I

Oncogene. 2020 Nov 13;:

Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography.

Tusamda Wakhloo N, Anders S, Badique F, Eichhorn M, Brigaud I, Petithory T, Vassaux M, Milan JL, Freund JN, Rühe J, Davidson PM, Pieuchot L, Anselme K

Biomaterials. 2020 Jan 2;234:119746

Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs.

Grall E, Gourain V, Naïr A, Martin E, Birling MC, Freund JN, Duluc I

Cell Death Dis. 2019 Oct 24;10(11):812

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.

Vidimar V, Licona C, Camacho RC, Guerin E, Coliat P, Venkatasamy A, Ali M, Guenot D, Le Lagadec R, Jung AC, Freund JN, Pfeffer M, Mellitzer G, Sava G, Gaiddon C

Cancer Lett.. 2018 Oct 16;:

Chromatin de-condensation by switching substrate elasticity.

Rabineau M, Flick F, Ehlinger C, Mathieu E, Duluc I, Jung M, Senger B, Kocgozlu L, Schaaf P, Lavalle P, Freund JN, Haikel Y, Vautier D

Sci Rep. 2018 Aug 23;8(1):12655

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, Onea A, Deschamps J, Beck F, Freund JN, Duluc I

J. Exp. Med.. 2018 Mar 5;215(3):911-926

Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing.

Balbinot C, Vanier M, Armant O, Nair A, Penichon J, Soret C, Martin E, Saandi T, Reimund JM, Deschamps J, Beck F, Domon-Dell C, Gross I, Duluc I, Freund JN

Cell Death Differ.. 2017 Sep;:

Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts.

Dillenseger JP, Goetz C, Sayeh A, Healy C, Duluc I, Freund JN, Constantinesco A, Aubertin-Kirch G, Choquet P

J Med Imaging (Bellingham). 2017 Jul;4(3):035503

Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer : impact on tumor growth and cell migration.

Romain B, Benbrika-Nehmar R, Marisa L, Legrain M, Lobstein V, Oravecz A, Poidevin L, Bour C, Freund JN, Duluc I, Guenot D, Pencreach E

Oncotarget. 2017 Mar;:

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Platet N, Hinkel I, Richert L, Murdamoothoo D, Moufok-Sadoun A, Vanier M, Lavalle P, Gaiddon C, Vautier D, Freund JN, Gross I

Cancer Lett.. 2017 Feb;386:57-64

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome.

Gillard L, Billiauws L, Stan-Iuga B, Ribeiro-Parenti L, Jarry AC, Cavin JB, Cluzeaud F, Mayeur C, Thomas M, Freund JN, Lacorte JM, Le Gall M, Bado A, Joly F, Le Beyec J

Sci Rep. 2016 Jun;6:28345

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, Freund JN, Domon-Dell C

Cancer Lett.. 2016 May;374(2):208-15

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.

Freund JN, Duluc I, Reimund JM, Gross I, Domon-Dell C

World J Gastroenterol. 2015 Feb 7;21(5):1436-43

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate.

Rabineau M, Flick F, Mathieu E, Tu A, Senger B, Voegel JC, Lavalle P, Schaaf P, Freund JN, Haikel Y, Vautier D

Biomaterials. 2015 Jan;37:144-55

Broader expression of the mouse Platelet Factor 4-Cre transgene beyond the megakaryocyte lineage.

Pertuy F, Aguilar A, Strassel C, Eckly A, Freund JN, Duluc I, Gachet C, Lanza F, Leon C

J Thromb Haemost. 2014 Nov 13

Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2).

Modica S, Cariello M, Morgano A, Gross I, Vegliante MC, Murzilli S, Salvatore L, Freund JN, Sabba C, Moschetta A

J Biol Chem. 2014 Oct 10;289(41):28421-32

Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice.

Treton X, Pedruzzi E, Guichard C, Ladeiro Y, Sedghi S, Vallee M, Fernandez N, Bruyere E, Woerther PL, Ducroc R, Montcuquet N, Freund JN, Van Seuningen I, Barreau F, Marah A, Hugot JP, Cazals-Hatem D, Bouhnik Y, Daniel F, Ogier-Denis E

PLoS One. 2014 Jul 9;9(7):e101669

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

Martianov I, Cler E, Duluc I, Vicaire S, Philipps M, Freund JN, Davidson I

PLoS One. 2014 Feb 3;9(2):e87365

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2.

Derbal-Wolfrom L, Pencreach E, Saandi T, Aprahamian M, Martin E, Greferath R, Tufa E, Choquet P, Lehn JM, Nicolau C, Duluc I, Freund JN

Oncogene. 2013 Sep 5;32(36):4313-8

Regulation of the tumor suppressor homeogene Cdx2 by HNF4alpha in intestinal cancer.

Saandi T, Baraille F, Derbal-Wolfrom L, Cattin AL, Benahmed F, Martin E, Cardot P, Duclos B, Ribeiro A, Freund JN, Duluc I

Oncogene. 2013 Aug 8;32(32):3782-8

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.

Chery C, Hehn A, Mrabet N, Oussalah A, Jeannesson E, Besseau C, Alberto JM, Gross I, Josse T, Gerard P, Gueant-Rodriguez RM, Freund JN, Devignes J, Bourgaud F, Peyrin-Biroulet L, Feillet F, Gueant JL

Biochimie. 2013 May;95(5):995-1001

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase.

Gueant JL, Caillerez-Fofou M, Battaglia-Hsu S, Alberto JM, Freund JN, Dulluc I, Adjalla C, Maury F, Merle C, Nicolas JP, Namour F, Daval JL

Biochimie. 2013 May;95(5):1033-40

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness.

Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C, Chartier NT, Plateroti M, Rouault JP, Freund JN, Billaud M, Almeida R

Nucleic Acids Res. 2013 Apr;41(7):3986-99

Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization.

Badique F, Stamov DR, Davidson PM, Veuillet M, Reiter G, Freund JN, Franz CM, Anselme K

Biomaterials. 2013 Apr;34(12):2991-3001

Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies.

De Mey JR, Freund JN

Tissue Barriers. 2013 Apr 1;1(2):e24965

Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division.

Rabineau M, Kocgozlu L, Dujardin D, Senger B, Haikel Y, Voegel JC, Freund JN, Schaaf P, Lavalle P, Vautier D

PLoS One. 2013 Oct 22;8(10):e78468

[Identity and intestinal pathologies: the Cdx2 homeotic gene].

Freund JN

Ann Pathol. 2012 Nov;32(5 Suppl):S24-7

Gastric intestinal metaplasia revisited: function and regulation of CDX2.

Barros R, Freund JN, David L, Almeida R

Trends Mol Med. 2012 Sep;18(9):555-63

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

Bellis J, Duluc I, Romagnolo B, Perret C, Faux MC, Dujardin D, Formstone C, Lightowler S, Ramsay RG, Freund JN, De Mey JR

J Cell Biol. 2012 Aug 6;198(3):331-41

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1beta, IL-6, TNF-alpha, COX-2, and apoptosisi.

Abdallah Hajj Hussein I, Freund JN, Reimund JM, Shams A, Yamine M, Leone A, Jurjus AR

J Biol Regul Homeost Agents. 2012 Jul-Sep;26(3):515-26.

Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and beta-catenin activity in colon cancer cells.

Hinkel I, Duluc I, Martin E, Guenot D, Freund JN, Gross I

Gastroenterology. 2012 Apr;142(4):875-885.e3

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.

Renouf B, Soret C, Saandi T, Delalande F, Martin E, Vanier M, Duluc I, Gross I, Freund JN, Domon-Dell C

Nucleic Acids Res. 2012 Apr;40(8):3456-69

Cdx2 determines the fate of postnatal intestinal endoderm.

Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F

Development. 2012 Feb;139(3):465-74

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity.

Kocgozlu L, Rabineau M, Koenig G, Haikel Y, Schaaf P, Freund JN, Voegel JC, Lavalle P, Vautier D

Biomaterials. 2012 Jan;33(3):798-809

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.

van de Ven C, Bialecka M, Neijts R, Young T, Rowland JE, Stringer EJ, Van Rooijen C, Meijlink F, Novoa A, Freund JN, Mallo M, Beck F, Deschamps J

Development. 2011 Aug;138(16):3451-62

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype.

Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R

Gut. 2011 Mar;60(3):290-8

Immunohistochemical expression of CDX2, beta-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer.

Laurent C, Svrcek M, Flejou JF, Chenard MP, Duclos B, Freund JN, Reimund JM

Inflamm Bowel Dis. 2011 Jan;17(1):232-40

CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula.

Martin E, Vanier M, Tavian M, Guerin E, Domon-Dell C, Duluc I, Gross I, Rowland J, Kim S, Freund JN

Pediatrics. 2010 Sep;126(3):e723-7

NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon.

Coant N, Ben Mkaddem S, Pedruzzi E, Guichard C, Treton X, Ducroc R, Freund JN, Cazals-Hatem D, Bouhnik Y, Woerther PL, Skurnik D, Grodet A, Fay M, Biard D, Lesuffleur T, Deffert C, Moreau R, Groyer A, Krause KH, Daniel F, Ogier-Denis E

Mol Cell Biol. 2010 Jun;30(11):2636-50

Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation.

Barros R, Camilo V, Pereira B, Freund JN, David L, Almeida R

Biochem Soc Trans. 2010 Apr;38(2):358-63.

Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease.

Entz-Werle N, Choquet P, Neuville A, Kuchler-Bopp S, Clauss F, Danse JM, Simo-Noumbissie P, Guerin E, Gaub MP, Freund JN, Boehm N, Constantinesco A, Lutz P, Guenot D, Perrin-Schmitt F

Transl Oncol. 2010 Dec 1;3(6):344-53.

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J

Dev Cell. 2009 Oct;17(4):516-26.

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.

Modica S, Morgano A, Salvatore L, Petruzzelli M, Vanier MT, Valanzano R, Esposito DL, Palasciano G, Duluc I, Freund JN, Mariani-Costantini R, Moschetta A

Gut. 2009 Sep;58(9):1250-9

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin.

Pons L, Battaglia-Hsu SF, Orozco-Barrios CE, Ortiou S, Chery C, Alberto JM, Arango-Rodriguez ML, Dumas D, Martinez-Fong D, Freund JN, Gueant JL

PLoS One. 2009 Jul 22;4(7):e6325.

Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene.

Benahmed F, Gross I, Gaunt SJ, Beck F, Jehan F, Domon-Dell C, Martin E, Kedinger M, Freund JN, Duluc I

Gastroenterology. 2008 Oct;135(4):1238-1247, 1247.e1-3

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R

J Pathol. 2008 Aug;215(4):411-20.

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer.

Bonhomme C, Calon A, Martin E, Robine S, Neuville A, Kedinger M, Domon-Dell C, Duluc I, Freund JN

Oncogene. 2008 Jul 24;27(32):4497-502

Inflammatory bowel disease in rats: bacterial and chemical interaction.

Hajj Hussein IA, Tohme R, Barada K, Mostafa MH, Freund JN, Jurjus RA, Karam W, Jurjus A

World J Gastroenterol. 2008 Jul 7;14(25):4028-39.

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.

Lu X, Freund JN, Muller M, Ravey J, Nicolas JP, Gueant JL, Namour F

Biochimie. 2008 May;90(5):697-704

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.

Calon A, Gross I, Lhermitte B, Martin E, Beck F, Duclos B, Kedinger M, Duluc I, Domon-Dell C, Freund JN

Gut. 2007 Dec;56(12):1688-95

Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice.

Choquet P, Calon A, Breton E, Beck F, Domon-Dell C, Freund JN, Constantinesco A

C R Biol. 2007 Nov;330(11):821-7

The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells.

Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I

J Biol Chem. 2007 Aug 3;282(31):22638-50

Precancerous lesions upon sporadic activation of beta-catenin in mice.

Coste I, Freund JN, Spaderna S, Brabletz T, Renno T

Gastroenterology. 2007 Apr;132(4):1299-308

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability.

Subtil C, Guerin E, Schneider A, Chenard MP, Martin E, Domon-Dell C, Duluc I, Brabletz T, Kedinger M, Duclos B, Gaub MP, Freund JN

Cancer Lett. 2007 Mar 18;247(2):197-203

The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells.

Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I

Am J Pathol. 2007 Feb;170(2):733-44.

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

Buchet-Poyau K, Courchet J, Le Hir H, Seraphin B, Scoazec JY, Duret L, Domon-Dell C, Freund JN, Billaud M

Nucleic Acids Res. 2007;35(4):1289-300

Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells.

Debruyne PR, Witek M, Gong L, Birbe R, Chervoneva I, Jin T, Domon-Cell C, Palazzo JP, Freund JN, Li P, Pitari GM, Schulz S, Waldman SA

Gastroenterology. 2006 Apr;130(4):1191-206.

CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions.

Kim HS, Lee JS, Freund JN, Min KW, Lee JS, Kim W, Juhng SW, Park CS

J Gastroenterol Hepatol. 2006 Feb;21(2):438-42.

Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells.

Turck N, Gross I, Gendry P, Stutzmann J, Freund JN, Kedinger M, Simon-Assmann P, Launay JF

Exp Cell Res. 2005 Feb 15;303(2):494-503

Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha.

Wang L, Klopot A, Freund JN, Dowling LN, Krasinski SD, Fleet JC

Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G943-53

Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression.

Brabletz T, Spaderna S, Kolb J, Hlubek F, Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C, Kirchner T, Freund JN

Cancer Res. 2004 Oct 1;64(19):6973-7.

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.

Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P

J Cell Biol. 2004 Jul 5;166(1):37-47.

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

Kim S, Domon-Dell C, Kang J, Chung DH, Freund JN, Evers BM

J Biol Chem. 2004 Feb 6;279(6):4285-91

Cdx1 homeobox gene during human colon cancer progression.

Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN

Oncogene. 2003 Sep 11;22(39):7913-21.